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人工腰椎间盘置换治疗退行性腰椎间盘疾病16例分析 被引量:4
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作者 吴亮 孙晓亮 +4 位作者 张雷 吴国峰 周剑 Yve Cartonne Pascal Moussellard 《中国组织工程研究与临床康复》 CAS CSCD 2012年第4期638-641,共4页
背景:与传统的单纯腰椎间盘切除和脊柱融合治疗方法相比,人工腰椎间盘置换具有明显的理论优势,已成为治疗退行性腰椎间盘疾病的最有希望的方法。目的:总结人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床疗效。方法:2007-05/2010... 背景:与传统的单纯腰椎间盘切除和脊柱融合治疗方法相比,人工腰椎间盘置换具有明显的理论优势,已成为治疗退行性腰椎间盘疾病的最有希望的方法。目的:总结人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床疗效。方法:2007-05/2010-10行人工腰椎间盘置换治疗退行性腰椎间盘疾病16例,其中男9例,女7例,平均年龄40.5岁(28~55岁)。结果与结论:随访时间6~36个月,置换后目测类比评分、Oswestry功能障碍指数、椎间隙高度均较置换前有显著改善(P〈0.01)。置换后腰椎活动度获有效维持,置换后腰椎活动度与置换前比较差异无显著性意义(P〉0.05)。结果显示人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床结果令人满意,但其远期效果尚待进一步观察。 展开更多
关键词 腰椎 椎间盘 假体 植入物 退行性腰椎间盘疾病
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Burden of venous thromboembolism in patients with pancreatic cancer 被引量:3
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作者 Corinne Frere 《World Journal of Gastroenterology》 SCIE CAS 2021年第19期2325-2340,共16页
Pancreatic cancer(PC)is a devastating malignancy with fewer than 10%of patients being alive at 5 years after diagnosis.Venous thromboembolism(VTE)occurs in approximatively 20%of patients with PC,resulting in increased... Pancreatic cancer(PC)is a devastating malignancy with fewer than 10%of patients being alive at 5 years after diagnosis.Venous thromboembolism(VTE)occurs in approximatively 20%of patients with PC,resulting in increased morbidity,mortality and significant health care costs.The management of VTE is particularly challenging in these frail patients.Adequate selection of the most appropriate anticoagulant for each individual patient according to the current international guidelines is warranted for overcoming treatment challenges.The International Initiative on Thrombosis and Cancer multi-language web-based mobile application(downloadable for free at www.itaccme.com)has been developed to help clinicians in decision making in the most complex situations.In this narrative review,we will discuss the contemporary epidemiology and burden of VTE in PC patients,the performances and limitations of current risk assessment models to predict the risk of VTE,as well as evidence from recent clinical trials for the primary prophylaxis and treatment of cancer-associated VTE that support updated clinical practice guidelines. 展开更多
关键词 Pancreatic cancer Venous thromboembolism Low-molecular weight heparin Direct oral anticoagulant Multi-language mobile application Risk-assessment models THROMBOPROPHYLAXIS
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Determinants of invasive strategy in elderly patients with non-ST elevation myocardial infarction 被引量:1
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作者 Antonin Negers Jacques Boddaert +5 位作者 Lucie Mora Jean-Louis Golmard Laura Moisi Ariel Cohen Jean-Philippe Collet Alice Breining 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第7期465-472,共8页
Background Knowledge gaps across literature prevent current guidelines from providing the profile of elderly patients most likely to derive benefit fi^om invasive strategy (IS) in non ST-elevation myocardial infarct... Background Knowledge gaps across literature prevent current guidelines from providing the profile of elderly patients most likely to derive benefit fi^om invasive strategy (IS) in non ST-elevation myocardial infarction (NSTEMI). Furthermore, the benefit of IS in a real-world elderly population with NSTEMI remains unclear. The aims of this study were to determine factors that lead the cardiologist to opt for an IS in elderly patients with NSTEMI, and to assess the impact of IS on the 6-month all-cause mortality. Methods This multicenter prospective study enrolled all consecutive patients aged 〉 75 years old who presented a NSTEMI and were hospitalized in cardiology intensive care unit between February 2014 and February 2015. Patients were compared on the basis of reperfusion strategy (invasive or conservative) and living status at six months, in order to determine multivariate predictors of the realization of an IS and multivariate predictors of 6-month mor- tality. Results A total of 141 patients were included; 87 (62%) underwent an IS. The strongest independent determinants of IS were younger age [odds ratio (OR): 0.85, 95%-confidence interval (CI): 0.78-0.92; P 〈 0.001) and lower "Cumulative Illness Rating Scale-Geriatric" number of categories score (OR: 0.83, 95%CI: 0.73-0.95; P = 0.002). IS was not significantly associated with 6-month survival (OR: 0.80, 95%CI: 0.27-2.38; P = 0.69). Conclusions In real-world elderly patients with NSTEMI, younger patients with fewer comorbidities profited more often from an IS. However, IS did not modify 6-month all-cause mortality. 展开更多
关键词 COMORBIDITY Coronary angiography Decision making MORTALITY Myocardial infarction
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治疗失败及复发结核病患者的耐药性:标准复治方案够吗? 被引量:4
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作者 H.T.W.Quy N.T.N.Lan +8 位作者 M.W.Borgdorff J.Grosset P.D.Linh L.B.Tung D.van Soolingen M.Raviglione N.V.C■ J.Broekmans 马玙 《国际结核病与肺部疾病杂志》 2003年第3期115-119,共5页
目的:确定新发涂阳结核病治疗后失败与复发患者的获得耐药性情况。方法:对越南新发涂阳结核病患者2901例的队列进行登记,登记时收集、贮存痰标本。治疗失败或复发时再次留痰。将二次痰标本进行培养、药敏试验及限制性内切酶片段长度多态... 目的:确定新发涂阳结核病治疗后失败与复发患者的获得耐药性情况。方法:对越南新发涂阳结核病患者2901例的队列进行登记,登记时收集、贮存痰标本。治疗失败或复发时再次留痰。将二次痰标本进行培养、药敏试验及限制性内切酶片段长度多态性(RFLP)分型。结果:40例失败患者中,有17例在初次登记时即为耐多药结核病(MDR)。非原发MDR的23例失败 患者中有15例(65%)为获得性MDR病例。39例复发患者及 143例对照者中均无原发MDR病例。结论:原发耐药性对治疗失败,复发及进一步产生的获得耐药性都是有明显影响的危险因素。因为80%的失败病例为 MDR,因此在对新病例具有高治愈率的控制规划中,失败病例不宜采用标准复治方案。 展开更多
关键词 结核病 耐多药 抗结核药物 治疗失败 越南
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国际糖尿病足工作组:促进糖尿病足溃疡创面愈合干预指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分 被引量:8
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作者 Gerry Rayman Prashant Vas +10 位作者 Ketan Dhatariya Vicki Driver Agnes Hartemann Magnus Londahl Alberto Piaggesi Jan Apelqvist Chris Attinger Fran Game 杨彩哲(译) 许樟荣(审校) 《感染.炎症.修复》 2019年第4期230-230,共1页
推荐1.考虑到疼痛或严重缺血等相对禁忌证,采用锐性清创术去除糖尿病足溃疡的腐肉、坏死组织和周围的胼胝优于其他方法。(GRADE推荐强度:强;证据质量:低)2.选择敷料主要是考虑渗出物控制、舒适性和成本。(强;低)3.不要使用含表面抗菌药... 推荐1.考虑到疼痛或严重缺血等相对禁忌证,采用锐性清创术去除糖尿病足溃疡的腐肉、坏死组织和周围的胼胝优于其他方法。(GRADE推荐强度:强;证据质量:低)2.选择敷料主要是考虑渗出物控制、舒适性和成本。(强;低)3.不要使用含表面抗菌药物的敷料以加速溃疡的愈合。(强;低)4.针对曾用最佳标准治疗难以愈合的未感染的神经性缺血性糖尿病足溃疡,可以考虑使用蔗糖八硫酸盐敷料(脂质水胶寡糖敷料—校者注)。 展开更多
关键词 糖尿病足 足溃疡 指南 创面愈合 敷料
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Partial Nephrectomy Allowed By Anti CD_(20) Antibody Treatment for Renal Cancer Associated with Acquired Haemophilia A
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作者 Tamas Kullmann Annick Ankri +2 位作者 Marc-Olivier Bitker Serge Herson Olivier Benveniste 《Journal of Cancer Therapy》 2011年第3期308-310,共3页
The case of a forty-five year old woman is presented who consulted for spontaneous haematomas of the thighs. The diagnosis of acquired haemophilia A associated to renal cancer was retained. She received anti CD20 mono... The case of a forty-five year old woman is presented who consulted for spontaneous haematomas of the thighs. The diagnosis of acquired haemophilia A associated to renal cancer was retained. She received anti CD20 monoclonal antibody treatment allowing her to undergo partial nephrectomy 4 months later without major complication. One year after surgery there is no sign of tumour recurrence. 展开更多
关键词 Acquired Haemophilia Arituximab Renal Cancer
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人工腰椎间盘置换术与单纯髓核摘除术治疗退行性腰椎间盘疾病的近期疗效比较 被引量:5
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作者 吴亮 孙晓亮 +4 位作者 张雷 吴国峰 周剑 Yve Cartonne Pascal Moussellard 《中国矫形外科杂志》 CAS CSCD 北大核心 2011年第21期1769-1772,共4页
[目的]对人工腰椎间盘置换术和单纯髓核摘除术治疗退行性腰椎间盘疾病的近期临床疗效进行比较。[方法]2007年5月~2010年5月行人工腰椎间盘置换术治疗退行性腰椎间盘疾病12例,其中男性7例,女性5例;平均年龄40.2岁(28~54岁)。同期行单... [目的]对人工腰椎间盘置换术和单纯髓核摘除术治疗退行性腰椎间盘疾病的近期临床疗效进行比较。[方法]2007年5月~2010年5月行人工腰椎间盘置换术治疗退行性腰椎间盘疾病12例,其中男性7例,女性5例;平均年龄40.2岁(28~54岁)。同期行单纯髓核摘除术治疗退行性腰椎间盘疾病20例,其中男性11例,女性9例;平均年龄38.1岁(24~51岁)。对两组病例手术前后的视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、腰椎活动度(ROM),以及椎间隙高度进行分析比较。[结果]随访时间平均20.1个月(6~30个月)。术后两组病例的VAS评分、ODI评分均较术前有显著改善(P<0.05)。末次随访时两组病例的VAS评分和ODI评分无统计学差异(P>0.05)。术后6个月两组ROM比较无显著差异(P>0.05),但末次随访时椎间盘置换组的ROM显著优于髓核摘除组(P<0.05)。术后椎间盘置换组椎间隙高度较术前显著增加(P<0.05),髓核摘除组椎间隙高度与术前相比无显著差异(P>0.05)。[结论]对于退行性腰椎间盘疾病,人工腰椎间盘置换术和单纯髓核摘除术均可达到良好的近期临床疗效。但在改善腰椎活动度和恢复椎间隙高度方面,人工腰椎间盘置换术更具优势。 展开更多
关键词 腰椎 椎间盘 髓核 假体和置入物
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Region 2 of 8q24 is associated with the risk of aggressive prostate cancer in Caribbean men of African descent from Guadeloupe (French West Indies)
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作者 Geraldine Cancel-Tassin Marc Romana +3 位作者 Cecile Gaffory Pascal Blanchet Olivier Cussenot Luc Multigner 《Asian Journal of Andrology》 SCIE CAS CSCD 2015年第1期117-119,I0010,共4页
Multiple regions of the genome have been associated with the risk of prostate cancer in Caucasians, particularly including several polymorphisms located at 8q24. Region 2 of 8q24 has been repeatedly found to be associ... Multiple regions of the genome have been associated with the risk of prostate cancer in Caucasians, particularly including several polymorphisms located at 8q24. Region 2 of 8q24 has been repeatedly found to be associated with the risk of prostate cancer among men of African descent, although one study performed in the Caribbean island of Jamaica did not report this finding. In this study, the single nucleotide polymorphism rs16901979, located in region 2 of 8q24, was genotyped in 498 cases of histologically confirmed prostate cancer and 541 controls from the French Caribbean islands of Guadeloupe, where the population is largely of African descent. The AA genotype and the A allele at rs16901979 were associated with elevated risks of prostate cancer (odds ratios [ORs] = 1.84, 95% confidence interval [95% CI] = 1.26-2.69, P= 0.002 and OR = 1.36, 95% CI = 1.13-1.64, P= 0.001, respectively). Following stratification of the patients by disease aggressiveness, as defined by the Gleason score, the pooled genotypes AC + AA were associated with a higher risk of a Gleasen score 〉7 at diagnosis (OR = 1.79, 95% CI = 1.17-2.73, P= 0.007). In summary, the A allele at rs16901979 was associated with the risk of prostate cancer in the Caribbean population of Guadeloupe, confirming its involvement in populations of African descent. Moreover, our study provides the first evidence of an association between this variant and the risk of aggressive prostate cancer. 展开更多
关键词 African Continental Ancestry Group AGGRESSIVENESS Caribbean region genetic predisposition to disease prostaticneoplasms
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