β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unkno...β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.展开更多
Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world.Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases,th...Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world.Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases,there is still no available therapeutic agent for most of the viruses in clinical practice.Coumarin is a chemical compound which is found naturally in a variety of plants,it can also be synthetically produced possessing diverse biological effects.More recently,reports have highlighted the potential role of coumarin derivatives as antiviral agents.This review outlines the advances in coumarin-based compounds against various viruses including human immunodeficiency virus,hepatitis virus,herpes simplex virus,Chikungunya virus and Enterovirus 71,as well as the structure activity relationship and the possible mechanism of action of the most potent coumarin derivatives.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82104158(to XT),31800887(to LY),31972902(to LY),82001422(to YL)China Postdoctoral Science Foundation,No.2020M683750(to LY)partially by Young Talent Fund of University Association for Science and Technology in Shaanxi Province of China,No.20200307(to LY).
文摘β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.
文摘Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world.Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases,there is still no available therapeutic agent for most of the viruses in clinical practice.Coumarin is a chemical compound which is found naturally in a variety of plants,it can also be synthetically produced possessing diverse biological effects.More recently,reports have highlighted the potential role of coumarin derivatives as antiviral agents.This review outlines the advances in coumarin-based compounds against various viruses including human immunodeficiency virus,hepatitis virus,herpes simplex virus,Chikungunya virus and Enterovirus 71,as well as the structure activity relationship and the possible mechanism of action of the most potent coumarin derivatives.
