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Strengthening Network Security: Deep Learning Models for Intrusion Detectionwith Optimized Feature Subset and Effective Imbalance Handling
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作者 Bayi Xu Lei Sun +2 位作者 Xiuqing Mao Chengwei Liu Zhiyi Ding 《Computers, Materials & Continua》 SCIE EI 2024年第2期1995-2022,共28页
In recent years,frequent network attacks have highlighted the importance of efficient detection methods for ensuring cyberspace security.This paper presents a novel intrusion detection system consisting of a data prep... In recent years,frequent network attacks have highlighted the importance of efficient detection methods for ensuring cyberspace security.This paper presents a novel intrusion detection system consisting of a data prepro-cessing stage and a deep learning model for accurately identifying network attacks.We have proposed four deep neural network models,which are constructed using architectures such as Convolutional Neural Networks(CNN),Bi-directional Long Short-Term Memory(BiLSTM),Bidirectional Gate Recurrent Unit(BiGRU),and Attention mechanism.These models have been evaluated for their detection performance on the NSL-KDD dataset.To enhance the compatibility between the data and the models,we apply various preprocessing techniques and employ the particle swarm optimization algorithm to perform feature selection on the NSL-KDD dataset,resulting in an optimized feature subset.Moreover,we address class imbalance in the dataset using focal loss.Finally,we employ the BO-TPE algorithm to optimize the hyperparameters of the four models,maximizing their detection performance.The test results demonstrate that the proposed model is capable of extracting the spatiotemporal features of network traffic data effectively.In binary and multiclass experiments,it achieved accuracy rates of 0.999158 and 0.999091,respectively,surpassing other state-of-the-art methods. 展开更多
关键词 Intrusion detection CNN BiLSTM BiGRU ATTENTION
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Technical note for intraoperative determination of proper acetabular cup size in primary total hip arthroplasty
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作者 Panagiotis Karampinas John Vlamis +5 位作者 Athanasios Galanis Michail Vavourakis Anastasia Krexi Evangelos Sakellariou Christos Patilas Spiros Pneumaticos 《World Journal of Methodology》 2024年第1期94-101,共8页
BACKGROUND Selecting the optimal size of components is crucial when performing a primary total hip arthroplasty.Implanting the accurate size of the acetabular component can occasionally be exacting,chiefly for surgeon... BACKGROUND Selecting the optimal size of components is crucial when performing a primary total hip arthroplasty.Implanting the accurate size of the acetabular component can occasionally be exacting,chiefly for surgeons with little experience,whilst the complications of imprecise acetabular sizing or over-reaming can be potentially devastating.AIM To assist clinicians intraoperatively with a simple and repeatable tip in elucidating the ambivalence when determining the proper acetabular component size is not straightforwardly achieved,specifically when surgeons are inexperienced or preoperative templating is unavailable.METHODS This method was employed in 263 operations in our department from June 2021 to December 2022.All operations were performed by the same team of joint reconstruction surgeons,employing a typical posterior hip approach technique.The types of acetabular shells implanted were:The Dynasty®acetabular cup system(MicroPort Orthopedics,Shanghai,China)and the R3®acetabular system(Smith&Nephew,Watford,United Kingdom),which both feature cementless press-fit design.RESULTS The mean value of all cases was calculated and collated with each other.We distinguished as oversized an implanted acetabular shell when its size was>2 mm larger than the size of the acetabular size indicator reamer(ASIR)or when the implanted shell was larger than 4 mm compared to the preoperative planned cup.The median size of the implanted acetabular shell was 52(48–54)mm,while the median size of the preoperatively planned cup was 50(48–56)mm,and the median size of the ASIR was 52(50–54)mm.The correlation coefficient between ASIR size and implanted acetabular component size exhibited a high positive correlation with r=0.719(P<0.001).Contrariwise,intraoperative ASIR measurements precisely predicted the implanted cups’size or differed by only one size(2 mm)in 245 cases.CONCLUSION In our study,we demonstrated that the size of the first acetabular reamer not entering freely in the acetabular rim corroborates the final acetabular component size to implant.This was also corresponding in the majority of the cases with conventional preoperative templating.It can be featured as a valid tool for avoiding the potentially pernicious complications of acetabular cup over-reaming and over-sizing in primary total hip arthroplasty.It is a simple and reproducible technical note useful for confirming the predicted acetabular cup size preoperatively;thus,its application could be considered routinely,even in cases where preoperative templating is unavailable. 展开更多
关键词 Acetabular shell Total hip arthroplasty HIP ACETABULUM Acetabular component Primary hip arthroplasty
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Single-center experience with Knee+^(TM) augmented reality navigation system in primary total knee arthroplasty
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作者 Evangelos Sakellariou Panagiotis Alevrogiannis +6 位作者 Fani Alevrogianni Athanasios Galanis Michail Vavourakis Panagiotis Karampinas Panagiotis Gavriil John Vlamis Stavros Alevrogiannis 《World Journal of Orthopedics》 2024年第3期247-256,共10页
BACKGROUND Computer-assisted systems obtained an increased interest in orthopaedic surgery over the last years,as they enhance precision compared to conventional hardware.The expansion of computer assistance is evolvi... BACKGROUND Computer-assisted systems obtained an increased interest in orthopaedic surgery over the last years,as they enhance precision compared to conventional hardware.The expansion of computer assistance is evolving with the employment of augmented reality.Yet,the accuracy of augmented reality navigation systems has not been determined.AIM To examine the accuracy of component alignment and restoration of the affected limb’s mechanical axis in primary total knee arthroplasty(TKA),utilizing an augmented reality navigation system and to assess whether such systems are conspicuously fruitful for an accomplished knee surgeon.METHODS From May 2021 to December 2021,30 patients,25 women and five men,under-went a primary unilateral TKA.Revision cases were excluded.A preoperative radiographic procedure was performed to evaluate the limb’s axial alignment.All patients were operated on by the same team,without a tourniquet,utilizing three distinct prostheses with the assistance of the Knee+™augmented reality navigation system in every operation.Postoperatively,the same radiographic exam protocol was executed to evaluate the implants’position,orientation and coronal plane alignment.We recorded measurements in 3 stages regarding femoral varus and flexion,tibial varus and posterior slope.Firstly,the expected values from the Augmented Reality system were documented.Then we calculated the same values after each cut and finally,the same measurements were recorded radiolo-gically after the operations.Concerning statistical analysis,Lin’s concordance correlation coefficient was estimated,while Wilcoxon Signed Rank Test was performed when needed.RESULTS A statistically significant difference was observed regarding mean expected values and radiographic mea-surements for femoral flexion measurements only(Z score=2.67,P value=0.01).Nonetheless,this difference was statistically significantly lower than 1 degree(Z score=-4.21,P value<0.01).In terms of discrepancies in the calculations of expected values and controlled measurements,a statistically significant difference between tibial varus values was detected(Z score=-2.33,P value=0.02),which was also statistically significantly lower than 1 degree(Z score=-4.99,P value<0.01).CONCLUSION The results indicate satisfactory postoperative coronal alignment without outliers across all three different implants utilized.Augmented reality navigation systems can bolster orthopaedic surgeons’accuracy in achieving precise axial alignment.However,further research is required to further evaluate their efficacy and potential. 展开更多
关键词 Augmented reality ORTHOPEDICS Total knee arthroplasty ROBOTICS KNEE NAVIGATION
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Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum:Two birds with one stone 被引量:4
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作者 Eva Zold Arpad Nagy +2 位作者 Katalin Devenyi Margit Zeher Zsolt Barta 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第18期2293-2295,共3页
Crohn's disease (CD) is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications. The purpose of treatment is long-term re... Crohn's disease (CD) is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications. The purpose of treatment is long-term remission, reduction of complications, and improvement of patients' quality of life. In many cases, this can be quite challenging and it is necessary to have a well thought out management strategy. We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia. In addition, there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities, indicative of pyoderma gangrenosum. The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab. A positive response to adalimumab therapy was observed: after 2 mo of therapy, the ulcerative skin lesion healed completely and the enterogastric fistula was closed affcer 5 mo adalimumab treatment. Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD. 展开更多
关键词 ADALIMUMAB Crohn's disease Pyoderma gangrenosum
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ECG stress test induced atrial ischemia in a patient with old inferior myocardial infarction due to a distal coronary artery lesion 被引量:3
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作者 Andras Vereckei Gabor Katona +3 位作者 Zsuzsanna Szelenyi Edit Takacs Pal Maurovich-Horvat David Becker 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第1期73-77,共5页
A 78-year-old man with a history of mitral valve prolapse underwent echocardiography during his cardiological check-up examination in 2011 in a symptom-free stage. Echocardiography revealed akinesis of the inferior se... A 78-year-old man with a history of mitral valve prolapse underwent echocardiography during his cardiological check-up examination in 2011 in a symptom-free stage. Echocardiography revealed akinesis of the inferior septum and inferobasal free wall as a novel finding suggesting a distal right coronary artery (RCA) lesion (Figure 1). The systolic left ventricular function was normal. Earlier echocardiographies did not show wall motion abnormalities. 展开更多
关键词 Atrial infarction Atrial ischemia ELECTROCARDIOGRAPHY
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The role of electrocardiography in the elaboration of a new paradigm in cardiac resynchronization therapy for patients with nonspecific intraventricular conduction disturbance 被引量:2
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作者 Andras Vereckei Gabor Katona +3 位作者 Zsuzsanna Szelenyi Gabor Szenasi Balint Kozman Istvan Karadi 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第2期118-125,共8页
Cardiac resynchronization therapy (CRT) is associated with a favorable outcome only in patients with left bundle branch block (LBBB) pattern and in patients with a QRS duration 〉 150 ms, in patients with non-LBBB... Cardiac resynchronization therapy (CRT) is associated with a favorable outcome only in patients with left bundle branch block (LBBB) pattern and in patients with a QRS duration 〉 150 ms, in patients with non-LBBB pattern with a QRS duration of 120-150 ms usually is not beneficial. After adjusting for QRS duration, QRS morphology was no longer a determinant of the clinical response to CRT. In contrast to the mainstream view, we hypothesized that the unfavorable CRT outcome in patients with non-LBBB and a QRS duration of 120-150 ms is not due to the QRS morphology itself, but to less dyssynchrony and unfavorable patient characteristics in this subgroup, such as more ischemic etiology and greater prevalence of male patients compared with patients with LBBB pattern. Further, the current CRT technique is devised to eliminate the dyssynchrony present in patients with LBBB pattern and inappropriate to eliminate the dyssynchrony in patients with non-LBBB pattern. We also hypothesized that electrocardiography may also provide information about the presence of interventricular and left intraventricular dyssynchrony and the approximate location of the latest activated left ventricular (LV) region. To this end, we devised new ECG criteria to estimate interventricular and LV intraventricular dyssynchrony and the approximate location of the latest activated LV region. Our preliminary data demonstrated that the latest activated LV region in patients with nonspecific intraventricular conduction disturbance (NICD) pattern might be at a remote site from that present in patients with LBBB pattern, which might necessitate the invention of a novel CRT technique for patients with NICD pattern. The application of the new interventricular and LV intraventricular dyssynchrony ECG criteria and a potential novel CRT technique might decrease the currently high nonresponder rate in patients with NICD pattern. 展开更多
关键词 Cardiac resynchronization therapy ELECTROCARDIOGRAPHY Heart failure
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Impact of living with bipolar patients: Making sense of caregivers' burden 被引量:1
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作者 Maurizio Pompili Désirée Harnic +10 位作者 Xenia Gonda Alberto Forte Giovanni Dominici Marco Innamorati Konstantinos N Fountoulakis Gianluca Serafini Leo Sher Luigi Janiri Zoltan Rihmer Mario Amore Paolo Girardi 《World Journal of Psychiatry》 SCIE 2014年第1期1-12,共12页
The aim of the present review was to examine objective and subjective burdens in primary caregivers(usually family members) of patients with bipolar disorder(BD) and to list which symptoms of the patients are consider... The aim of the present review was to examine objective and subjective burdens in primary caregivers(usually family members) of patients with bipolar disorder(BD) and to list which symptoms of the patients are considered more burdensome by the caregivers. In order to provide a critical review about caregiver's burden in patients with bipolar disorder, we performed a detailed Pub Med, Bio Med Central, ISI Web of Science, Psyc INFO, Elsevier Science Direct and Cochrane Library search to identify all papers and book chapters in English published during the period between 1963 and November 2011. The highest levels of distress were caused by the patient's behavior and the patient's role dysfunction(work, education and social relationships). Furthermore, the caregiving role compromises other social roles occupied by the caregiver, becoming part of the heavy social cost of bipolar affective disorder. There is a need to better understand caregivers' views and personal perceptions of the stresses and demands arising from caring for someone with BD in order to develop practical appropriate interventions and to improve the training of caregivers. 展开更多
关键词 BIPOLAR DISORDER CAREGIVERS BURDEN Prevention
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Bidirectional link between diabetes mellitus and coronavirus disease 2019 leading to cardiovascular disease:A narrative review 被引量:1
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作者 Vijay Viswanathan Anudeep Puvvula +13 位作者 Ankush D Jamthikar Luca Saba Amer M Johri Vasilios Kotsis Narendra N Khanna Surinder K Dhanjil Misha Majhail Durga Prasanna Misra Vikas Agarwal George D Kitas Aditya M Sharma Raghu Kolluri Subbaram Naidu Jasjit S Suri 《World Journal of Diabetes》 SCIE 2021年第3期215-237,共23页
Coronavirus disease 2019(COVID-19)is a global pandemic where several comorbidities have been shown to have a significant effect on mortality.Patients with diabetes mellitus(DM)have a higher mortality rate than non-DM ... Coronavirus disease 2019(COVID-19)is a global pandemic where several comorbidities have been shown to have a significant effect on mortality.Patients with diabetes mellitus(DM)have a higher mortality rate than non-DM patients if they get COVID-19.Recent studies have indicated that patients with a history of diabetes can increase the risk of severe acute respiratory syndrome coronavirus 2 infection.Additionally,patients without any history of diabetes can acquire newonset DM when infected with COVID-19.Thus,there is a need to explore the bidirectional link between these two conditions,confirming the vicious loop between“DM/COVID-19”.This narrative review presents(1)the bidirectional association between the DM and COVID-19,(2)the manifestations of the DM/COVID-19 loop leading to cardiovascular disease,(3)an understanding of primary and secondary factors that influence mortality due to the DM/COVID-19 loop,(4)the role of vitamin-D in DM patients during COVID-19,and finally,(5)the monitoring tools for tracking atherosclerosis burden in DM patients during COVID-19 and“COVID-triggered DM”patients.We conclude that the bidirectional nature of DM/COVID-19 causes acceleration towards cardiovascular events.Due to this alarming condition,early monitoring of atherosclerotic burden is required in“Diabetes patients during COVID-19”or“new-onset Diabetes triggered by COVID-19 in Non-Diabetes patients”. 展开更多
关键词 COVID-19 Diabetes mellitus Bidirectional association Cardiovascular disease Atherosclerotic burden Imaging tools
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Inherited arrhythmias and gene therapy: Are there any ethical considerations to take into account? 被引量:1
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作者 Michael Spartalis Eleftherios Spartalis Gerasimos Siasos 《World Journal of Cardiology》 2023年第12期623-626,共4页
Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology.In the past half-century,there has been significant advan-cement in the development and implementation of inn... Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology.In the past half-century,there has been significant advan-cement in the development and implementation of innovative ablation treatments and approaches.However,the treatment of arrhythmias continues to be inade-quate.Several arrhythmias,such as ventricular tachycardia and atrial fibrillation,pose significant challenges in terms of therapeutic efficacy,whether through interventional procedures or the administration of antiarrhythmic drugs.Cardio-logists are engaged in ongoing research to explore innovative methodologies,such as genome editing,with the purpose of effectively managing arrhythmias and meeting the growing needs of patients afflicted with rhythm disturbances.The field of genome editing has significant promise and has the potential to serve as a highly effective personalized therapy for rhythm disorders in patients.However,several ethical issues must be considered. 展开更多
关键词 ARRHYTHMIA Sudden cardiac death Genome editing Long QT Channelo-pathies Mutation
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关于糖尿病心脏的新观点:从患病到衰竭
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作者 胡蜀红 刘娟 +2 位作者 袁刚 E.Standl O.Schnell 《德国医学》 2001年第6期317-318,共2页
近几年来尽管介入心脏病学和心脏外科治疗方法的不断增多和应用,患有急性冠状动脉综合征(ACS)和其它心脏病的糖尿病患者的死亡率仍然很高,并且在西方国家数以百万计的糖尿病患者中每一个过早死亡的几乎都是由心脏病引起的.
关键词 糖尿病 心脏病 流行病学 自然病程 预后
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Non-parasitic splenic cysts: A report of three cases 被引量:11
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作者 Macheras A Misiakos EP +3 位作者 Liakakos T Mpistarakis D Fotiadis C Karatzas G 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第43期6884-6887,共4页
Primary splenic cyst is a relatively rare disease, and the majority of cases are classified as epithelial cysts. Three cases with nonparasitic splenic cysts are presented: two epithelial and one pseudocyst. All cases ... Primary splenic cyst is a relatively rare disease, and the majority of cases are classified as epithelial cysts. Three cases with nonparasitic splenic cysts are presented: two epithelial and one pseudocyst. All cases had an atypical symptomatology, consisted mainly of fullness in the left upper abdomen and a palpable mass. Preoperative diagnosis was established with ultrasonography and computerized tomography. Two cases with large cysts located in the splenic hilum were treated with open complete splenectomy. The most recent case, a pseudocyst, was managed laparoscopically with partial cystectomy. All cases did not have any problems or recurrence during follow-up. Laparoscopic partial cystectomy is an acceptable procedure for the treatment of splenic cysts, because it cures the disease preserving the splenic tissue. Complete splenectomy is reserved for cases in which cyst excision cannot be done otherwise. 展开更多
关键词 SPLEEN Epithelial cyst SURGERY LAPAROSCOPY
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Psychosocial stress and liver disease status 被引量:8
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作者 Cristin Constantin Vere Costin Teodor Streba +2 位作者 Letitia Maria Streba Alin Gabriel Ionescu Felix Sima 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第24期2980-2986,共7页
"Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namel... "Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma. 展开更多
关键词 STRESS Chronic viral hepatitis CIRRHOSIS CARCINOMA HEPATOCELLULAR Liver pathology
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Cytopathologic diagnosis of fine needle aspiration biopsies of thyroid nodules 被引量:14
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作者 Evangelos P Misiakos Niki Margari +6 位作者 Christos Meristoudis Nickolas Machairas Dimitrios Schizas Konstantinos Petropoulos Aris Spathis Petros Karakitsos Anastasios Machairas 《World Journal of Clinical Cases》 SCIE 2016年第2期38-48,共11页
Fine-needle aspiration(FNA) cytology is an important diagnostic tool in patients with thyroid lesions.Several systems have been proposed for the cyropathologic diagnosis of the thyroid nodules.However cases with indet... Fine-needle aspiration(FNA) cytology is an important diagnostic tool in patients with thyroid lesions.Several systems have been proposed for the cyropathologic diagnosis of the thyroid nodules.However cases with indeterminate cytological findings still remain a matter of debate.In this review we analyze all literature regarding Thyroid Cytopathology Reporting systems trying to identify the most suitable methodology to use in clinical practice for the preoperative diagnosis of thyroid nodules.A review of the English literature was conducted,and data were analyzed and summarized and integrated from the authors' perspective.The main purpose of thyroid FNA is to identify patients with higher risk for malignancy,and to prevent unnecessary surgeries for benign conditions.The Bethesda System for Reporting Thyroid Cytopathology is the most widely used system for the diagnosis of thyroid FNA specimens.This system also contains guidelines for the diagnosis and treatment of indeterminate or suspicious for malignancy cases.In conclusion,patients who require repeated FNAs for indeterminate diagnoses will be resolved by repeat FNA in a percentage of 72%-80%. 展开更多
关键词 THYROID CYTOPATHOLOGY NODULE PAPILLARY cancer Fine needle BIOPSY
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Circulating tumor cells in pancreatic cancer patients:Enrichment and cultivation 被引量:16
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作者 Vladimir Bobek Robert Gurlich +1 位作者 Petra Eliasova Katarina Kolostova 《World Journal of Gastroenterology》 SCIE CAS 2014年第45期17163-17170,共8页
AIM: To investigate the feasibility of separation and cultivation of circulating tumor cells (CTCs) in pancreatic cancer (PaC) using a filtration device.
关键词 Pancreatic cancer Circulating tumor cells BIOMARKER CULTIVATION
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Composite Control of Linear/Adaptive Variable Structure Control 被引量:6
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作者 顾文锦 张翼飞 李常平 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2001年第1期49-56,共8页
This paper first researches the system's response-feature due to the sliding regime related to the slope of a switching line, and then makes an investigation on the existence condition and hitting condition. Based... This paper first researches the system's response-feature due to the sliding regime related to the slope of a switching line, and then makes an investigation on the existence condition and hitting condition. Based on these conditions, the paper proposes a switching function that can realize an error adaptive variable structure control (AVSC) successfully. For eliminating the chattering of the sliding regime, this VSS introduces a dead zone, in which the PID control is applied. The composition of the PID control and the AVSC is called composite control of linear / AVSC. When the control signal is a large one, the AVSC is applied in the majority, and when the signal is a low one, the PID control is applied. Finally, an example of overload control of an anti-ship aerodynamic missile is illustrated to show the application of the composite control. 展开更多
关键词 Adaptive control systems AERODYNAMICS Missiles Three term control systems
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Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients 被引量:14
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作者 Jingjing Liu Qixin Mao +3 位作者 Yan Liu Xiaomeng Hao Sheng Zhang Jin Zhang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第1期46-54,共9页
The purpose of this study was to identify and validate circulating microRNAs (miRNAs) in human plasma for use as breast cancer (BC) biomarkers and to analyze their relationship to clinicopathologic features and it... The purpose of this study was to identify and validate circulating microRNAs (miRNAs) in human plasma for use as breast cancer (BC) biomarkers and to analyze their relationship to clinicopathologic features and its preliminary biological function. Genome-wide expression profiling of miRNAs in BC was investigated by microarray analysis, miR-155 was up-regulated greater than two-fold in BC compared with Normal Adjacent Tissue (NAT), whereas let-7b, miR-381, miR-10b, miR-125a-Sp, miR-335, miR-205 and miR-145 were down- regulated greater than two-fold. Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of BC patients compared to controls. Using real-time PCR (RT-PCR), we analyzed miR-205 and miR-155 in archived serum from 30 participants, 20 with breast cancer and I0 healthy people, miR-205 was down-regulated in BC patient serum while miR-155 was up-regulated. Furthermore, we analyzed the relationship between the expression levels of these two miRNAs and the clinicopathologic parameters of BC patients. High expression of miR155 was associated with clinical stage, molecular type, Ki-67 and p53 in BC patients (P〈0.05). By contrast, we found no significant correlation between miR-205 and BC patient clinicopathologic parameters. Functional analysis showed that ectopic expression of miR-205 significantly inhibits cell proliferation and promotes apoptosis, miR-205 was down- regulated and miR-155 was up-regulated in BC patient serum, miR-155 was positive correlated with clinical stage and 16-67 and negatively correlated with p53 status. 展开更多
关键词 Breast cancer MICRORNAS miR-205 MIR-155
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Laparoscopic splenectomy:Current concepts 被引量:14
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作者 Evangelos P Misiakos George Bagias +1 位作者 Theodore Liakakos Anastasios Machairas 《World Journal of Gastrointestinal Endoscopy》 CAS 2017年第9期428-437,共10页
Since early 1990's,when it was inaugurally introduced,laparoscopic splenectomy has been performed with excellent results in terms of intraoperative and postoperative complications.Nowadays laparoscopic splenectomy... Since early 1990's,when it was inaugurally introduced,laparoscopic splenectomy has been performed with excellent results in terms of intraoperative and postoperative complications.Nowadays laparoscopic splenectomy is the approach of choice for both benign and malignant diseases of the spleen.However some contraindications still apply.The evolution of the technology has allowed though,cases which were considered to be absolute contraindications for performing a minimal invasive procedure to be treated with modified laparoscopic approaches.Moreover,the introduction of advanced laparoscopic tools for ligation resulted in less intraoperative complications.Today,laparoscopic splenectomy is considered safe,with better outcomes in comparison to open splenectomy,and the increased experience of surgeons allows operative times comparable to those of an open splenectomy.In this review we discuss the indications and the contraindications of laparoscopic splenectomy.Moreover we analyze the standard and modified surgical approaches,and we evaluate the short-term and long-term outcomes. 展开更多
关键词 LAPAROSCOPY SPLENECTOMY SPLENOMEGALY Hand-assisted-laparoscopic-splenectomy Lymphoma
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Soluble adhesion molecules ICAM-1,VCAM-1,P-selectin in children with Helicobacter pylori infection 被引量:5
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作者 Elzbieta Maciorkowska Maciej Kaczmarski +2 位作者 Anatol Panasiuk Katarzyna Kondej-Muszynska Andrzej Kemonai 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第43期6745-6750,共6页
AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric mucosa.METHODS: The ... AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric mucosa.METHODS: The study included 106 children: 59children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System classification.The evaluation of sP-selectin, sIC AM-1, sVCAM-1 levels in the sera of children was carried out using ELISA test.RESULTS: The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P<0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P<0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori infection.CONCLUSION: Assessment of adhesive molecules (sPselectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation, sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children. 展开更多
关键词 SVCAM-1 SICAM-1 SP-SELECTIN Helicobacter pylori
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Abscesses of the spleen:Report of three cases 被引量:3
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作者 Constantin Fotiadis Giagkos Lavranos +1 位作者 Pavlos Patapis Gabriel Karatzas 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第19期3088-3091,共4页
Abscess of the spleen is a rare discovery, with about 600 cases in the international literature so far. Although it may have various causes, it is most usually associated with trauma and infections of the spleen. The ... Abscess of the spleen is a rare discovery, with about 600 cases in the international literature so far. Although it may have various causes, it is most usually associated with trauma and infections of the spleen. The latter are more common in the presence of a different primary site of infection, especially endocarditis or in cases of ischemic infarcts that are secondarily infected. Moreover, immunosuppression is a major risk factor. Clinical examination usually reveals a combination of fever, left-upper-quadrant abdominal pain and vomiting. Laboratory findings are not constant. Imaging is a necessary tool for establishing the diagnosis, with a choice between ultrasound and computed tomography. Treatment includes conservative measures, and surgical intervention. In children and in cases of solitary abscesses with a thick wall, percutaneous catheter drainage may be attempted. Otherwise, splenectomy is the preferred approach in most centers. Here, we present three cases of splenic abscess. In all three, splenectomy was performed, followed by rapid clinical improvement. These cases emphasize that current understanding of spleen abscess etiology is still limited, and a study for additional risk factors may be necessary. 展开更多
关键词 SPLEEN ABSCESS SPLENECTOMY INFECTIONS TRAUMA
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Histological outcome of chronic hepatitis B in children treated with interferon alpha 被引量:3
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作者 Sobaniec-Lotowska Maria Elzbieta Lebensztejn Dariusz Marek 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第45期7179-7182,共4页
AIM: To evaluate the effect of interferon alpha (IFN-α) treatment on the liver histology in children with chronic hepatitis B and to evaluate the usefulness of various histological scoring systems of liver histolo... AIM: To evaluate the effect of interferon alpha (IFN-α) treatment on the liver histology in children with chronic hepatitis B and to evaluate the usefulness of various histological scoring systems of liver histology in this group of patients. METHODS: Fibrosis stage and inflammation grade were assessed according to Batts and Ludwig, Ishak et al., and IETAVIR (only fibrosis stage) before and 12 mo after IFN-α treatment termination in 93 children aged 2-16 years with chronic hepatitis B. RESULTS: None of the three numerical scoring systems for liver fibrosis showed statistically significant differences in liver fibrosis, while evolution of inflammatory activity revealed statistically significant improvement in the whole group of children with chronic hepatitis B treated with IFN-α and in responders. Significantly positive correlations were found between fibrosis stage and inflammation grade in the respective scoring systems. CONCLUSION: Treatment with IFN-α did not improve histological fibrosis but decreased inflammatory activity in children with chronic hepatitis B. The three semiquantitative scoring systems seem to be comparable in the estimation of the inflammation grade and fibrosis stage in this group of children. 展开更多
关键词 CHILDREN Chronic hepatitis B Interferonalpha Fibrosis stage Inflammation grade Semiquantitative scoring systems
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