The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is design...The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic.展开更多
L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide meta...L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail.展开更多
基金supported by the National Natural Science Foundation of China (51962008)。
文摘The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic.
基金Project supported by the National Natural Science Foundation of China(51962008)Jiangxi Provincial Natural Science Foundation(20202BABL203018)。
文摘L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail.
