BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical resection.We demonstrated that combination therapy ...BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical resection.We demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced HCC.CASE SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal pain.Enhanced computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/mL.Therefore,he was judged to have advanced HCC.During treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of lenvatinib.In the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be halved.Postoperative pathological diagnosis indicated a complete response.The patient recovered well after the operation,and no tumor recurrence was found.CONCLUSION Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant effect.Individualized drug adjustments should be made during any treatment according to the patient's tolerance to treatment.展开更多
BACKGROUND Psychological intervention nursing(PIN)has been considered to have a curative effect on cesarean section(CS)post-operative recovery.However,the therapeutic mechanisms remain obscure.AIM To explore the effec...BACKGROUND Psychological intervention nursing(PIN)has been considered to have a curative effect on cesarean section(CS)post-operative recovery.However,the therapeutic mechanisms remain obscure.AIM To explore the effects of PIN combined with acupressure massage on CS postoperative recovery.METHODS A retrospective study was conducted on 150 pregnant women admitted to an obstetrics department between January 2020 and January 2023.The control group(CG)received acupressure therapy(n=73),and the intervention group(IG)received acupressure therapy and PIN therapy(n=77).Postoperative recovery time was assessed by anal-exhausting,defecation,bed activity,breastfeeding,and hospital stay times.Adverse effects,including infection,bleeding,limb numbness,intrauterine hematoma,urinary retention,and venous thromboembolism,were recorded.the pain visual analogue scale(VAS)was used to evaluate the degree of pain.Anxiety and depression status were qualitatively assessed using the selfrating anxiety scale(SAS),self-rating depression scale(SDS),and Edinburgh postpartum depression scale(EPDS).The Pittsburgh sleep quality index(PSQI)was used to compare sleep quality between the groups.RESULTS The baseline data and SAS,SDS,EPDS,and PSQI scores did not significantly differ before CS(P>0.05)and neither did complication rates between the two groups after CS(P>0.05).However,anal-exhausting,defecation,waking up,breastfeeding,and hospitalization times were significantly shorter for participants in the IG than those for participants in the CG(P<0.05).The VAS,SAS,SDS,EPDS,and PSQI scores of the IG were significantly lower than those of the CG(P<0.05).CONCLUSION PIN,combined with acupressure massage,effectively promotes maternal recovery,reduces post-CS pain,and improves post-operative negative emotions and sleeping quality.展开更多
The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become...The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become more closely intertwined and mutually reinforcing.In this context,countries across the world have been prompted to look for healthy,feasible and sustainable solutions to keep their socioeconomic development momentum on track.展开更多
The renewal and cultural revival of its two mother rivers has made Shanghai more beautiful,and now,it must acquire new industrial muscle as well.WHEN American historian Jeffrey Wasserstrom came to Shanghai in March 20...The renewal and cultural revival of its two mother rivers has made Shanghai more beautiful,and now,it must acquire new industrial muscle as well.WHEN American historian Jeffrey Wasserstrom came to Shanghai in March 2009,a year before the World Expo 2010,he exclaimed,“Shanghai’s future is beyond imagination.”At that time,Shanghai had carried out riverbank management in some sections of the Huangpu River,one of the two mother rivers of the city,and restored its cultural functions.展开更多
Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. ...Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ<sub>1-42</sub>, an injury model was established by subjecting OLN-93 cells to Aβ<sub>1-42</sub> exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ<sub>1-42</sub>. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ<sub>1-42</sub>-induced damage of OL.展开更多
The method of describing deformation camouflage spots based on feature space has some shortcomings,such as inaccurate description and difficult reproduction.Depending on the strong fitting ability of the generative ad...The method of describing deformation camouflage spots based on feature space has some shortcomings,such as inaccurate description and difficult reproduction.Depending on the strong fitting ability of the generative adversarial network model,the distribution of deformation camouflage spot pattern can be directly fitted,thus simplifying the process of spot extraction and reproduction.The requirements of background spot extraction are analyzed theoretically.The calculation formula of limiting the range of image spot pixels is given and two kinds of spot data sets,forestland and snowfield,are established.Spot feature is decomposed into shape,size and color features,and a GAN(Generative Adversarial Network)framework is established.The effects of different loss functions on network training results are analyzed in the experiment.In the meantime,when the input dimension of generator network is 128,the balance between sample diversity and quality can be achieved.The effects of sample generation are investigated in two aspects.Subjectively,the probability of the generated spots being distinguished in the background is counted,and the results are all less than 20% and mostly close to zero.Objectively,the features of the spot shape are calculated and the independent sample T-test is applied to verify that the features are from the same distribution,and all the P-Values are much higher than 0.05.Both subjective and objective methods prove that the spots generated by this method are similar to the background spots.The proposed method can directly generate the desired camouflage pattern spots,which provides a new technical method for the deformation camouflage pattern design and camouflage effect evaluation.展开更多
Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January, 2009. The journal covers the desig...Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January, 2009. The journal covers the design, construction, protection,展开更多
Dear sir/madam,We would like to invite you to submit to Journal of Landscape Research editorial office. The aim of this English academicjournal is to introduce the research achievements of Chinese landscape architectu...Dear sir/madam,We would like to invite you to submit to Journal of Landscape Research editorial office. The aim of this English academicjournal is to introduce the research achievements of Chinese landscape architecture to the world, enhance the researchers’chances to participate in international academic exchanges,展开更多
Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design...Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design, construction, protection, planning and management of natural and cultural landscapes, involving various展开更多
Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January, 2009. The journal covers the desig...Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January, 2009. The journal covers the design, construction, protection,展开更多
Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design...Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design, construction, protection, planning and management of natural and cultural landscapes, involving various展开更多
With the hope of providing basis for sound development of rural sports tourism industry in economic less-developed region and the establishment of macro industry policy,this paper demonstrated the selection of develop...With the hope of providing basis for sound development of rural sports tourism industry in economic less-developed region and the establishment of macro industry policy,this paper demonstrated the selection of development way,space frame and product system of rural sports tourism industry in southern Jiangxi Province by consulting document literature and conducting field research and based on the analysis of social background for the rise of rural sports tourism.展开更多
Dear sir/madam,We would like to have your contributions to Journal of Landscape Research editorialoffice.This English academic journal is to introduce the research achievements of
Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorial office. This English academic iournal is to introduce the research achievements of Chinese landscape architecture to ...Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorial office. This English academic iournal is to introduce the research achievements of Chinese landscape architecture to the world, enhance the researchers’ chances to participate in international academic exchanges, and promote the development of landscape researches in China.展开更多
Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorialoffice.This English academic journal is to introduce the research achievements of Chineselandscape architecture to the...Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorialoffice.This English academic journal is to introduce the research achievements of Chineselandscape architecture to the world, enhance the researchers’ chances to participate ininternational展开更多
Welcomes Your Papers!Meteorological and Environmental Research （SSN 2152-3940）is a comprehenstye meteorologlcoland environmental scientiflc iournal founded by wu Chu（USA-China）Science ＆ Cuiture Media Co.in Januar...Welcomes Your Papers!Meteorological and Environmental Research （SSN 2152-3940）is a comprehenstye meteorologlcoland environmental scientiflc iournal founded by wu Chu（USA-China）Science ＆ Cuiture Media Co.in January,2010,in Rhode Island,USA展开更多
Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorialoffice. This English academic journal is to introduce the research achievements of
Meteorological and Environmental Research (ISSN 2152-3940) is a comprehensive meteorological and environmental scientific journal founded by Wu Chu (USA-China) Science & Culture Media Co. in January, 2010, in Rhod...Meteorological and Environmental Research (ISSN 2152-3940) is a comprehensive meteorological and environmental scientific journal founded by Wu Chu (USA-China) Science & Culture Media Co. in January, 2010, in Rhode Island, USA. The journal covers main research and application areas of meteorology and environment, such as展开更多
Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design...Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design, construction, protection, planning展开更多
基金Supported by Shanghai Hospital Development Center Foundation,No.SHDC2022CRS033.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical resection.We demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced HCC.CASE SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal pain.Enhanced computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/mL.Therefore,he was judged to have advanced HCC.During treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of lenvatinib.In the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be halved.Postoperative pathological diagnosis indicated a complete response.The patient recovered well after the operation,and no tumor recurrence was found.CONCLUSION Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant effect.Individualized drug adjustments should be made during any treatment according to the patient's tolerance to treatment.
基金Project(P2021G053) supported by China Railway Corporation’s Science and Technology Research and Development ProgramProject(2021YJ022) supported by the Science and Technology Development Fund of China Academy of Railway Sciences Group Co.,Ltd。
基金the Ethic Committee of Second Affiliated Hospital of Gannan Medical University。
文摘BACKGROUND Psychological intervention nursing(PIN)has been considered to have a curative effect on cesarean section(CS)post-operative recovery.However,the therapeutic mechanisms remain obscure.AIM To explore the effects of PIN combined with acupressure massage on CS postoperative recovery.METHODS A retrospective study was conducted on 150 pregnant women admitted to an obstetrics department between January 2020 and January 2023.The control group(CG)received acupressure therapy(n=73),and the intervention group(IG)received acupressure therapy and PIN therapy(n=77).Postoperative recovery time was assessed by anal-exhausting,defecation,bed activity,breastfeeding,and hospital stay times.Adverse effects,including infection,bleeding,limb numbness,intrauterine hematoma,urinary retention,and venous thromboembolism,were recorded.the pain visual analogue scale(VAS)was used to evaluate the degree of pain.Anxiety and depression status were qualitatively assessed using the selfrating anxiety scale(SAS),self-rating depression scale(SDS),and Edinburgh postpartum depression scale(EPDS).The Pittsburgh sleep quality index(PSQI)was used to compare sleep quality between the groups.RESULTS The baseline data and SAS,SDS,EPDS,and PSQI scores did not significantly differ before CS(P>0.05)and neither did complication rates between the two groups after CS(P>0.05).However,anal-exhausting,defecation,waking up,breastfeeding,and hospitalization times were significantly shorter for participants in the IG than those for participants in the CG(P<0.05).The VAS,SAS,SDS,EPDS,and PSQI scores of the IG were significantly lower than those of the CG(P<0.05).CONCLUSION PIN,combined with acupressure massage,effectively promotes maternal recovery,reduces post-CS pain,and improves post-operative negative emotions and sleeping quality.
文摘The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become more closely intertwined and mutually reinforcing.In this context,countries across the world have been prompted to look for healthy,feasible and sustainable solutions to keep their socioeconomic development momentum on track.
文摘The renewal and cultural revival of its two mother rivers has made Shanghai more beautiful,and now,it must acquire new industrial muscle as well.WHEN American historian Jeffrey Wasserstrom came to Shanghai in March 2009,a year before the World Expo 2010,he exclaimed,“Shanghai’s future is beyond imagination.”At that time,Shanghai had carried out riverbank management in some sections of the Huangpu River,one of the two mother rivers of the city,and restored its cultural functions.
文摘Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ<sub>1-42</sub>, an injury model was established by subjecting OLN-93 cells to Aβ<sub>1-42</sub> exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ<sub>1-42</sub>. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ<sub>1-42</sub>-induced damage of OL.
基金This research was funded by Natural Science Foundation of Jiangsu Province,grant number BK20180579.
文摘The method of describing deformation camouflage spots based on feature space has some shortcomings,such as inaccurate description and difficult reproduction.Depending on the strong fitting ability of the generative adversarial network model,the distribution of deformation camouflage spot pattern can be directly fitted,thus simplifying the process of spot extraction and reproduction.The requirements of background spot extraction are analyzed theoretically.The calculation formula of limiting the range of image spot pixels is given and two kinds of spot data sets,forestland and snowfield,are established.Spot feature is decomposed into shape,size and color features,and a GAN(Generative Adversarial Network)framework is established.The effects of different loss functions on network training results are analyzed in the experiment.In the meantime,when the input dimension of generator network is 128,the balance between sample diversity and quality can be achieved.The effects of sample generation are investigated in two aspects.Subjectively,the probability of the generated spots being distinguished in the background is counted,and the results are all less than 20% and mostly close to zero.Objectively,the features of the spot shape are calculated and the independent sample T-test is applied to verify that the features are from the same distribution,and all the P-Values are much higher than 0.05.Both subjective and objective methods prove that the spots generated by this method are similar to the background spots.The proposed method can directly generate the desired camouflage pattern spots,which provides a new technical method for the deformation camouflage pattern design and camouflage effect evaluation.
文摘Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January, 2009. The journal covers the design, construction, protection,
文摘Dear sir/madam,We would like to invite you to submit to Journal of Landscape Research editorial office. The aim of this English academicjournal is to introduce the research achievements of Chinese landscape architecture to the world, enhance the researchers’chances to participate in international academic exchanges,
文摘Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design, construction, protection, planning and management of natural and cultural landscapes, involving various
文摘Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January, 2009. The journal covers the design, construction, protection,
文摘Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design, construction, protection, planning and management of natural and cultural landscapes, involving various
基金Supported by Humanities and Social Sciences Research Project of Universities and Colleges in Jiangxi Province(TY1211)Project of Ganzhou Federation of Social Sciences(13213)
文摘With the hope of providing basis for sound development of rural sports tourism industry in economic less-developed region and the establishment of macro industry policy,this paper demonstrated the selection of development way,space frame and product system of rural sports tourism industry in southern Jiangxi Province by consulting document literature and conducting field research and based on the analysis of social background for the rise of rural sports tourism.
文摘Dear sir/madam,We would like to have your contributions to Journal of Landscape Research editorialoffice.This English academic journal is to introduce the research achievements of
文摘Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorial office. This English academic iournal is to introduce the research achievements of Chinese landscape architecture to the world, enhance the researchers’ chances to participate in international academic exchanges, and promote the development of landscape researches in China.
文摘Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorialoffice.This English academic journal is to introduce the research achievements of Chineselandscape architecture to the world, enhance the researchers’ chances to participate ininternational
文摘Welcomes Your Papers!Meteorological and Environmental Research （SSN 2152-3940）is a comprehenstye meteorologlcoland environmental scientiflc iournal founded by wu Chu（USA-China）Science ＆ Cuiture Media Co.in January,2010,in Rhode Island,USA
文摘Dear sir/madam, We would like to have your contributions to Journal of Landscape Research editorialoffice. This English academic journal is to introduce the research achievements of
文摘Meteorological and Environmental Research (ISSN 2152-3940) is a comprehensive meteorological and environmental scientific journal founded by Wu Chu (USA-China) Science & Culture Media Co. in January, 2010, in Rhode Island, USA. The journal covers main research and application areas of meteorology and environment, such as
文摘Dear sir/madam, Journal of Landscape Research (ISSN 1943-989X) is a monthly academic journal founded by Wu Chu (USA-China) Science & Culture Media Co. (Cranston, USA) in January,2009. The journal covers the design, construction, protection, planning
