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Cerium(Ⅳ)ammonium nitrate(CAN)-mediated regioselective synthesis and anticancer activity of 6-substituted 5,8-dimethoxy-1,4-naphthoquinone
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作者 Guang Huang Hui-Ran Zhao +5 位作者 Qing-Qing Meng Wen Zhou Qi-Jing Zhang Jin-Yun Dong Jia-Hua Cui Shao-Shun Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第7期1553-1558,共6页
6-Substituted 5,8-O-dimethyl-1,4-naphthoquinones(6-DMNQ),the promising anticancer scaffolds,were selectively generated by oxidative demethylation of 2-substituted 1,4,5,8-tetramethoxynaphthalenes with CAN in EtOAc/H... 6-Substituted 5,8-O-dimethyl-1,4-naphthoquinones(6-DMNQ),the promising anticancer scaffolds,were selectively generated by oxidative demethylation of 2-substituted 1,4,5,8-tetramethoxynaphthalenes with CAN in EtOAc/H2O in comparatively high yields.An interesting finding was that apart from the reported electron-withdrawing effects of substituents on position 2 of naphthalene ring,regioselective synthesis of 6-DMNQ was largely dependent on the steric effects in CAN-mediated oxidation.The selective cytotoxicities of 6-DMNQ from the in vitro cell-based assays were exhibited between the cancer cells and normal cells.Moreover,most of sulfur-containing 6-DMNQ derivatives displayed better anticancer activities than the corresponding oxygen-containing ones,which could provide an available strategy for the design of 6-DMNQ derivatives as potential anticancer agents. 展开更多
关键词 6-Substituted 5 8-O-dimethyl-1 4- naphthoquinone Cerium(Ⅳ) ammonium nitrate Regioselective oxidation Steric effects Antitumor activity Sulfur-containing
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Brainin A,a novel flavanol from Brainea insignis 被引量:1
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作者 Ming Hui Yang Le Cai +2 位作者 Zhi Gang Tai Xue Qiong Yang Zhong Tao Ding 《Chinese Chemical Letters》 SCIE CAS CSCD 2011年第4期455-457,共3页
A novel flavanol bearing phenylpropionic acid moiety at C-4 through a C-C bonding,named brainin A(1),was isolated from the rhizomes of Brainea insignis.Its structure was elucidated on the basis of spectral data incl... A novel flavanol bearing phenylpropionic acid moiety at C-4 through a C-C bonding,named brainin A(1),was isolated from the rhizomes of Brainea insignis.Its structure was elucidated on the basis of spectral data including 2D NMR and HR-ESI-MS. 展开更多
关键词 FERN FLAVANOL Brainea insignis Brainin A
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Two Unusual Flavanol Derivatives from Brainea insignis 被引量:1
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作者 杨明惠 蔡乐 +3 位作者 沈晓静 赵冕 尹田鹏 丁中涛 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第6期1323-1326,共4页
Two new flavanol derivatives, bearing phenylpropionic acid moiety at C-4 through a C--C bonding, named brainin B (1) and brainin C (2), were isolated from Brainea insignis. Their structures were elucidated by NMR ... Two new flavanol derivatives, bearing phenylpropionic acid moiety at C-4 through a C--C bonding, named brainin B (1) and brainin C (2), were isolated from Brainea insignis. Their structures were elucidated by NMR and MS spectrometry, Brainins B and C were tested for their antioxidant properties in DPPH (2,2-diphenyl-l-picryl- hydrazyl) radical scavenging, and both compounds displayed potent antioxidant activities. 展开更多
关键词 Brainea insignis FLAVANOL DPPH radical scavenging activity
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