This study aimed to evaluate the correlation between nursing informatics(NI)competency and information literacy skills for evidencebased practice(EBP)among intensive care nurses.This cross-sectional study was conducte...This study aimed to evaluate the correlation between nursing informatics(NI)competency and information literacy skills for evidencebased practice(EBP)among intensive care nurses.This cross-sectional study was conducted on 184 nurses working in intensive care units(ICUs).The study data were collected through demographic information,Nursing Informatics Competency Assessment Tool(NICAT),and information literacy skills for EBP questionnaires.The intensive care nurses received competent and low-moderate levels for the total scores of NI competency and information literacy skills,respectively.They received a moderate score for the use of different information resources but a low score for information searching skills,different search features,and knowledge about search operators,and only 31.5%of the nurses selected the most appropriate statement.NI competency and related subscales had a significant direct bidirectional correlation with information literacy skills for EBP and its subscales(P<0.05).Nurses require a high level of NI competency and information literacy for EBP to obtain up-to-date information and provide better care and decision-making.Health planners and policymakers should develop interventions to enhance NI competency and information literacy skills among nurses and motivate them to use EBP in clinical settings.展开更多
Cancer is one of the main challenges of the health system around the world.This disease is increasing in developing countries and imposes heavy costs on patients and governments.On the other hand,despite various drugs...Cancer is one of the main challenges of the health system around the world.This disease is increasing in developing countries and imposes heavy costs on patients and governments.On the other hand,despite various drugs,the death rate among cancer patients is still high and the current treatments have many harmful effects.In the traditional medicine of different countries,there are many medicinal plants that can be effective in the treatment of cancer.Ferula plants are traditionally used as spices and food or for medicinal purposes.Ferula assa-foetida is one of the famous plants of this genus,which has been used for the treatment of various diseases since ancient times.Among the main compounds of this plant,we can mention monoterpenes,sulfide compounds and polyphenols,which can show different therapeutic effects.This article has been compiled with the aim of collecting evidence and articles related to the anti-cancer effects of extracts,derived compounds,essential oils and nanoparticles containing Ferula assa-foetida.This review article was prepared by searching the terms Ferula assa-foetida and cancer,and relevant information was collected through searching electronic databases such as ISI Web of Knowledge,PubMed,and Google Scholar.Fortunately,the results of this review showed that relatively comprehensive studies have been conducted in this field and shown that Ferula assa-foetida can be very promising in the treatment of cancer.展开更多
Objective:To elucidate the possible role of unfractionated heparin in patients with failed repeated in in vitro fertilization and embryo transfer(IVF-ET)and thrombophilia.Methods:This case control study evaluated the ...Objective:To elucidate the possible role of unfractionated heparin in patients with failed repeated in in vitro fertilization and embryo transfer(IVF-ET)and thrombophilia.Methods:This case control study evaluated the efficacy of the unfractionated heparin in increasing the pregnancy and implantation ratio in women with recurrent IVF-ET failures.Eighty-six women received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)with a record of three or more previous IVF-ET failures.Participants were randomly distributed into two groups.Group A(n=43)received unfractionated heparin 5000 IU twice daily,and group B(n=43)did not take any antithrombotic drugs.Coagulation abnormalities such as factor桋Leiden(FVL)mutation,methylene tetra hydro folate reductase(MTHFR)mutation and prothrombin mutation(F栻)were evaluated.Age,body mass index,basal follicular stimulating hormone,basal estradiol,duration of infertility,and number of IVF-ET failures were compared between two groups.Results:45.0%and 17.4%of women were pregnant with and without MTHFR and prothrombin mutation,respectively,when they received unfractionated heparin treatment.The implantation rate was more in group A(12.5%)than group B(4.3%)and differences in the fertilization rate of the two groups were observed(27.7%vs.35.9%).The clinical pregnancy rate per cycle was remarkably more in group A(30.2%)than group B(14.0%).Conclusions:Heparin is a safe and valuable treatment for patients with repeated IVF-ET failures.The clinical pregnancy and implantation rates are higher in the heparin-treated group in contrast with the control group.展开更多
BACKGROUND It has been said that the number of orthopaedic claims has increased in the last few years. Investigation through the most prevalent cause would help to prevent further cases.AIM To review the cases of medi...BACKGROUND It has been said that the number of orthopaedic claims has increased in the last few years. Investigation through the most prevalent cause would help to prevent further cases.AIM To review the cases of medical complaints in orthopedic patients who had been involved in a traumatic accident.METHODS A retrospective multi-center review of trauma orthopaedic-related malpractice lawsuits from 2010 to 2021 was conducted utilizing the regional medicolegal database. Defendant and plaintiff characteristics along with fracture location, allegations, and litigation outcomes were investigated.RESULTS A total of 228 claims referred to trauma-related conditions with a mean age of 31.29 ± 12.56 were enrolled. The most common injuries were at hand, thigh, elbow, and forearm, respectively.Likewise, the most common alleged complication was related to malunion or nonunion. In 47% of the cases, the main problem that led to the complaint was the inappropriate or insufficient explanation to the patient, and in 53%, there was a problem in the surgery. Eventually, 76% of the complaints resulted in a defense verdict, and 24% resulted in a plaintiff verdict.CONCLUSION Surgical treatment of hand injuries and surgery in non-educational hospitals received the most complaints. The majority of litigation outcomes were caused by a physician’s failure to fully explain and educate the traumatic orthopedic patients and technological errors.展开更多
To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumat...To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.展开更多
BACKGROUND: Bile duct ligation(BDL) and subsequent cholestasis are correlated with oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic,and hepatoprotective properties. Howe...BACKGROUND: Bile duct ligation(BDL) and subsequent cholestasis are correlated with oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic,and hepatoprotective properties. However, the molecular mechanism underlying quercetin-mediated hepatoprotection is not fully understood. The current study was to evaluate mechanisms of hepatoprotective effect of quercetin in BDL rat model.METHODS: We divided male Wistar rats into 4 groups(n=8 for each): sham, sham+quercetin(30 mg/kg per day), BDL, and BDL+quercetin(30 mg/kg per day). Four weeks later, the rats were sacrificed, the blood was collected for liver enzyme measurements and liver for the measurement of Rac1, Rac1-GTP and NOX1 mR NA and protein levels by quantitative PCR and Western blotting, respectively.RESULTS: Quercetin significantly alleviated liver injury in BDL rats as evidenced by histology and reduced liver enzymes.Furthermore, the m RNA and protein expression of Rac1,Rac1-GTP and NOX1 were significantly increased in BDL rats compared with those in the sham group(P<0.05); quercetin treatment reversed these variables back toward normal(P<0.05). Another interesting finding was that the antioxidant markers e.g. superoxide dismutase and catalase were elevated in quercetin-treated BDL rats compared to BDL rats(P<0.05).CONCLUSION: Quercetin demonstrated hepatoprotective activity against BDL-induced liver injury through increasing antioxidant capacity of the liver tissue, while preventing the production of Rac1, Rac1-GTP and NOX1 proteins.展开更多
Objective: To investigate and predict the effects of climate change on the potential distribution of the main vector and reservoir hosts of the disease in Yazd province in the future.Methods: Distribution data for vec...Objective: To investigate and predict the effects of climate change on the potential distribution of the main vector and reservoir hosts of the disease in Yazd province in the future.Methods: Distribution data for vector and reservoir hosts of zoonotic cutaneous leishmaniasis in Yazd province were obtained from earlier studies conducted in the area.MaxEnt ecological niche modeling was used to predict environmental suitability.BCC-CSM1-1(m) model and two climate change scenarios, RCP 4.5 and RCP 8.5 were used for horizons 2030 and 2050 climate projections.Future projections were based on data of a regional climate change model.Results: With both scenarios in 2030 and 2050, the results of jackknife test indicated that the mean temperature of wettest quarter and temperature annual range had the greatest effect on the model for the vector and the reservoir hosts, respectively.Conclusions: The climate conditions are the major determinants of zoonotic cutaneous leishmaniasis incidence rate in Yazd Province.These climate conditions provide favorable habitats for ease transmission of zoonotic cutaneous leishmaniasis in this endemic area.Habitats suitability for the vector and reservoir will be expanding in the coming years compared with the current conditions, such that, in horizon 2030 & 2050, the probability of the presence of the vector and reservoir within 38 580 and 37 949 km^2, respectively, from Yazd province is above 60%.Moreover, an increase is predicted in the presence of the vector in the western parts and the reservoir in the northern and central parts of the province in the future.Understanding the role of environmental and bioclimatic factors in zoonotic cutaneous leishmaniasis occurrence can provide a guide for policy-makers in the creation and implementation of more effective policies for prevention and control.展开更多
Objective:To determine the temporal patterns of cumulative incidence of brucellosis using autoregressive integrated moving average models.Methods:This cross-sectional study employed yearly and monthly data of 1117 lab...Objective:To determine the temporal patterns of cumulative incidence of brucellosis using autoregressive integrated moving average models.Methods:This cross-sectional study employed yearly and monthly data of 1117 laboratory-confirmed human brucellosis cases from January 2013 to December 2018 using the Yazd brucellosis national surveillance system.The monthly incidences constructed a timeseries model.The trend of cumulative incidence was perceived by tracing a line plot,which displayed a seasonal trend with periodicity.Thus,the ARIMA models were selected.Thereafter,Akaike information criteria(AIC)and Bayesian information criterion(BIC)values among different models indicated a preferable model from models which were expanded by diverse lags[(3,0,3),(2,0,3),(3,0,2),(4,0,3)and(3,0,4)].Then,the achieved ARIMA model was applied to the forecasting cumulative incidence of monthly brucellosis incidences.All analyses were performed using Stata,version 11.2.Results:For the ARIMA(3,0,4)model,MAPE value was 56.20%with standard error 0.009–0.016,and white noise diagnostic check(Q=19.79,P=0.975)for the residuals of the selected model showed that the data were completely modelled.The monthly incidences that were fitted by the ARIMA(3,0,4)model,with AIC(25.7)and BIC(43.35)with a similar pattern of actual cases from 2013 to 2018 and forecasting incidences from January 2019 to December 2019 were,respectively,0.50,0.44,0.45,0.49,0.55,0.58,0.56,0.51,0.46,0.44,0.45 and 0.49 per 100000 people.Conclusions:In summary,the study showed that the ARIMA(3,0,4)model can be applied to forecast human brucellosis patterns in Yazd province,supplementing present surveillance systems,and may be better for health policy-makers and planners.展开更多
Objective:To investigate the epidemiological pattern of animal bites in Yazd Province,central Iran.Methods:In this cross-sectional study,8 545 individuals with animal bites who were referred to the Yazd Province Rabie...Objective:To investigate the epidemiological pattern of animal bites in Yazd Province,central Iran.Methods:In this cross-sectional study,8 545 individuals with animal bites who were referred to the Yazd Province Rabies Treatment Center were investigated using the census method from April 2013 to March 2017.The variables included:demographic information,household living condition,the type of biting animals,the domesticated and wild animals,the time of biting based on year,the residence location (urban or rural),and the treatment status.Data were analyzed by descriptive statistics using Excel 2013,SPSS version 25 and Arc GIS 14.1 Software.Results:A total of 8 545 cases of animal bites were reported in Yazd province from 2013 to 2017.The most animal bites (with 4 253 case of bites) and the lowest animal bites (with 121 case of bites) occurred in Yazd and Bahabad district,respectively.The incidence of animal bites was 168.4 per 100 000 people during the five-year period.Most of cases (73.9%) occurred in urban areas.Dog and cat bites accounted for 47.6% and 47.4% of all cases,respectively.Most of animal bites were reported in the summer (29.4%).Sixty percent of the cases received incomplete treatments,while 40% of them received complete treatments.During this study,three positive cases of fatal rabies from dog bites were reported.Conclusions:The incidence of animal bites is high in Yazd province,and more patients are bitten by dog and cat.Hence,educational,preventive,and informative programs are required to reduce the incidence of animal bites.展开更多
Objectives:To investigate the epidemiology of animal bites and associated factors in Abadeh district(central Iran)from 2012 to 2018.Methods:In this cross-sectional study,1407 individuals with animal bites who were ref...Objectives:To investigate the epidemiology of animal bites and associated factors in Abadeh district(central Iran)from 2012 to 2018.Methods:In this cross-sectional study,1407 individuals with animal bites who were referred to the Abadeh Rabies Treatment Center were investigated by using the census method from 2012 to 2018.The variables included the victim's demographic information(age,gender,occupation),the type of biting animals(dog,cat,and other animals),the domesticated and wild animals,the time of biting based on year and month,the residence location(urban or rural),the treatment status,and the anatomical location of the wounds.Results:The annual incidence rate of animal bites was 189.62 per 100000 population.Totally 83.4%of the victims were male.The average age was(33.66±18.97)years and individuals in the age range of 36-50 years were greater at risk.Most of the animal bites were from dogs(77.8%).About two thirds(62.1%)of the bites were from household animals.A total of 57.1%of individuals lived in urban areas.Most victims were engaged in farming and animal husbandry.The highest prevalence of animal bites(37.4%)happened in the summer.None of the patients had any clinical signs of rabies.Conclusions:To reduce the incidence of animal bites,high-risk groups including farmers and ranchers should be educated about bite prevention,and it should be ensured that they are managed correctly.展开更多
Background: Pulp stones are calcified masses formed in the primary and permanent dentitions. The ischemic cardiovascular disorders (CVD) can be the first health problem of the world. It seems that there is a relations...Background: Pulp stones are calcified masses formed in the primary and permanent dentitions. The ischemic cardiovascular disorders (CVD) can be the first health problem of the world. It seems that there is a relationship between pulp stones and cardiovascular diseases to determine the diagnostic value of panoramic dental radiographs as non-invasive test for the early detection of CVD. Methods and Materials: The subjects of the study came from patients presenting to Dental Radiology Department of Dental School in Yazd who aged 30 - 64 years, had 8 natural teeth. They were referred to the Cardiovascular Center of Afshar Hospital in Yazd for cardiovascular evaluation. To set the cut-off point, the ratio of teeth with pulp stones to the total number of teeth for each person was calculated and also ABI for diagnosing IHD via ROC curve was used. Results: Only 3.8% of patients without pulp stone were affected by ischemic heart disease (IHD). About Sixty seven percent (67.3%) of individuals had at least one tooth with pulp stone. In individuals without IHD, 5% of the teeth showed pulp stone while this rate was 45% (9 times) in CVD patients. The number of patients for whom the ratio of teeth with pulp stone to total number of teeth was 0.2 or more, was 138.7 times greater than the other. Conclusion: The dentists, who order panoramic radiographs for the treatment of patients, exactly study those teeth for the presence of pulp stones. The ratio of teeth with pulp stone to total teeth equal 0.2 or more was a good tool for early detection of CVD.展开更多
The used water for human consumption must be free of microorganisms and chemicals that cause risk in the human health. In this study, water quality of 18 rural area of Abarkouh was determined and compared the conventi...The used water for human consumption must be free of microorganisms and chemicals that cause risk in the human health. In this study, water quality of 18 rural area of Abarkouh was determined and compared the conventional monitoring method (According to ISIR (Institute of Standards and Industrial Research of Iran), 1053 and 4208) and use of electronic system method (Patent in industrial property general office of Iran, 77815). Free chlorine monitoring and pH test done by health workers in the conventional method and the results will be sent to the Health Network monthly. Sampling for microbiological testing is done monthly based on population (According to ISIR, 4208). On the electronic system, the procedure is also done by health workers, but the result will be sent to the receiver device by using a cell phone. According to the chlorine test results if the free chlorine residual reported zero, microbiological sampling was done by a health expert. Finally, the number of chlorine test and microbiological sampling and the results of these experiments collected in the both methods and recorded in SPSS 22 then were analyzed by using chi-square test and Fisher exact test. The result of microbiological experiments shows that the sampling rate decreased 29% in using of electronic system method in comparison to the conventional monitoring method while the number of microbial defect detection increased 19% in drinking water networks monitoring by electronic system. Using of electronic system monitoring can reduce the rate and cost of microbiological sampling and its experiments and increase accuracy of these tests, in this way it will increase the quality and safety of drinking water in distribution network in small and dispersed rural communities.展开更多
Objectives: Considering the growing need for using a variety of new nonpharmacological methods in treating depression, this quasi experimental study was conducted to investigate the effect of aerobic indoor exercise i...Objectives: Considering the growing need for using a variety of new nonpharmacological methods in treating depression, this quasi experimental study was conducted to investigate the effect of aerobic indoor exercise in a gym compared with green exercise in an outdoor green environment of an urban park on triple categories of affective, cognitive and somatic symptoms of depression and to examine its psychological mediators of perceived stress and coping strategies. Methods: Forty six female outpatients with major depressive disorder were divided into 3 conditions of indoor exercise + routine pharmacotherapy (n = 15), green exercise + routine pharmacotherapy (n = 15), and a routine pharmacotherapy alone as the control group (n = 16). The exercise used for both indoor and green exercise conditions consisted of 36 one hour sessions (three times per week) with an intensity of 50% - 70% of the maximum heart rate. The participants completed the pre- and post-intervention depression, stress and coping questionnaires including Beck Depression Inventory-II, Perceived Stress Scale and Coping Inventory for Stressful Situations. Results: The findings indicated a significant decrease in the post-intervention scores of all three categories of affective, cognitive and somatic symptoms of depression and perceived stress in both exercise groups compared with the control group, but there was no significant difference between two exercise groups. With respect to the use of problem-focused, emotion-focused and avoidant-focused coping methods, there was no significant difference between post-intervention scores of all groups. Conclusion: In the clinical settings, both of the indoor exercise and green exercise programs can help to further improvement in all three categories of affective, cognitive and somatic symptoms of depression as an adjunct (or independent) treatment to the same degree, especially mediated by reducing the amount of perceived stress, but not through any significant changes in cognitive-behavioral coping strategies.展开更多
Groundwater is considered as one of the most important sources for water supply in Iran.The Fasa Plain in Fars Province,Southern Iran is one of the major areas of wheat production using groundwater for irrigation.A la...Groundwater is considered as one of the most important sources for water supply in Iran.The Fasa Plain in Fars Province,Southern Iran is one of the major areas of wheat production using groundwater for irrigation.A large population also uses local groundwater for drinking purposes.Therefore,in this study,this plain was selected to assess the spatial variability of groundwater quality and also to identify main parameters affecting the water quality using multivariate statistical techniques such as Cluster Analysis(CA),Discriminant Analysis(DA),and Principal Component Analysis(PCA).Water quality data was monitored at 22 different wells,for five years(2009-2014)with 10 water quality parameters.By using cluster analysis,the sampling wells were grouped into two clusters with distinct water qualities at different locations.The Lasso Discriminant Analysis(LDA)technique was used to assess the spatial variability of water quality.Based on the results,all of the variables except sodium absorption ratio(SAR)are effective in the LDA model with all variables affording 92.80%correct assignation to discriminate between the clusters from the primary 10 variables.Principal component(PC)analysis and factor analysis reduced the complex data matrix into two main components,accounting for more than 95.93%of the total variance.The first PC contained the parameters of TH,Ca2+,and Mg2+.Therefore,the first dominant factor was hardness.In the second PC,Cl-,SAR,and Na+were the dominant parameters,which may indicate salinity.The originally acquired factors illustrate natural(existence of geological formations)and anthropogenic(improper disposal of domestic and agricultural wastes)factors which affect the groundwater quality.展开更多
Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure...Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.展开更多
BACKGROUND:Numerous drugs have been proposed to alleviate pain in patients with biliary colic,especially opioids,but still there is a tendency to use less narcotics because of their side effects and the unwillingness ...BACKGROUND:Numerous drugs have been proposed to alleviate pain in patients with biliary colic,especially opioids,but still there is a tendency to use less narcotics because of their side effects and the unwillingness of some patients.The present study aimed to compare the analgesic effect of paracetamol combined with low-dose morphine versus morphine alone in patients with biliary colic.METHODS:A randomized double-blind controlled trial was performed in 98 patients with biliary colic,recruited from two emergency departments from August 2012 to August 2013.Eleven patients were excluded and the remaining were randomized into two groups:group A received 0.05mg/kg morphine+1 000 mg paracetamol in 100 m L normal saline and group B received 0.1 mg/kg morphine+normal saline(100 m L)as placebo.Pain scores were recorded using visual analogue scale(VAS)at baseline and 15 and 30 minutes after drug administration.Adverse effects and the need for rescue medication(0.75 g/kg intravenous fentanyl)were also reported within 60 minutes of drug administration.RESULTS:Before the infusion,the mean±SD VAS scores were 8.73±1.57 in group A and8.53±1.99 in group B.At 15 minutes after drug administration,the mean±SD VAS scores were2.16±1.90 in group A vs.2.51±1.86 in group B;mean difference was–0.35,and 95%CI–1.15 to 0.45(P=0.38).At 30 minutes the mean±SD VAS scores were 1.66±1.59 in group A vs.2.14±1.79 in group B;mean difference was–0.48,and 95%CI–1.20 to 0.24(P=0.19).The mean pain scores in the two groups at 15 and 30 minutes demonstrated no significant difference.CONCLUSION:Paracetamol combined with low-dose morphine may be effective for pain management in patients with biliary colic.展开更多
Objective:To determine the rate of carcass and offal condemnation in the animals slaughtered at Yazd slaughterhouse,Yazd,Iran.Methods:In a nine-month retrospective survey from June 2011 to March 2012,all the carcasses...Objective:To determine the rate of carcass and offal condemnation in the animals slaughtered at Yazd slaughterhouse,Yazd,Iran.Methods:In a nine-month retrospective survey from June 2011 to March 2012,all the carcasses and offal condemnations for large animals(cattle and camels) and small animals(sheep and goats)in Yazd Slaughterhouse were carefully recorded daily.Results:In total,2741 large animals(cattle and camels) and 77515 small animals(sheep and goats) were slaughtered during the period of this survey.Six carcasses(0.21%) of the large animals and 18 carcasses(0.02%) of the small animals were condemned.For large animals,condemnations in summer and autumn were significantly greater than winter(P<0.05).Condemnation rate of liver,lungs and kidneys for the large animals were 5.36%,21.23%and 3.68%respectively and for the small animals were 4.37%,5.46%and 0.51%respectively.The main recorded reasons for carcass condemnations in both large and small animals were icterus and cachexia.The most prevalent lesion resulting in offal condemnation was due to parasitic infection specially metacestods.Conclusions:This study aimed to show the efficiency of documentation records during meal inspection at slaughterhouses to monitor the amount of condemnation and possible approaches to better awareness about the future preventive programs.Considering the percentage of condemnation of carcass and offal in the present study and their price in Iranian markets,the overall economic losses seems to be notable at Yazd slaughterhouse.展开更多
Background:Several studies have tried to evaluate the effects of stem cell therapy for spinal cord injury in animal models and human trials.Bone marrow mesenchymal stem cells are one of the safe and available candidat...Background:Several studies have tried to evaluate the effects of stem cell therapy for spinal cord injury in animal models and human trials.Bone marrow mesenchymal stem cells are one of the safe and available candidate cells with established beneficial therapeutic effects for bone and cartilage repair.However,there are some doubts regarding their therapeutic efficacy for nervous system disorders.Bone marrow mesenchymal stem cells have been used in some clinical trials for spinal cord injury but their precise mechanism of action and also their safety has not been investigated.Available experimental reports do not provide sufficient and convincing evidence to persuade therapists to perform further clinical trials.In the present study we have used detailed staining methods to clearly show the entire structure of the injured spinal cord and the effects of bone marrow mesenchymal stem cells treatment on this tissue.Methods:Intrathecal injection of neutral red stained bone marrow mesenchymal stem cells were done in a rat model of spinal cord injury and the fate of the transplanted cells,immunologic responses in the host tissue,and tumor generation were assessed by using brightfield and fluorescence microscopy.Sensory-motor functions were also evaluated in the animals.Results:Injected cells could migrate to the site of the injury and differentiate into oligodendrocytes and astrocytes.Immuno-histological assays showed no cells expressing CD2,CD3,CD15 and CD45 in host tissues,and sensory-motor assessments revealed that there were some partial improvements.Conclusion:Present study provides strong evidence that mesenchymal stem cell therapy is safe and could be helpful for the remyelination of injured nerve fibers in the acute phase of injury.展开更多
Objective:Transcription factor GATA4 has significant roles in embryonic heart development.Mutations of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of ...Objective:Transcription factor GATA4 has significant roles in embryonic heart development.Mutations of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of GATA4 mutations in CHD phenotypes,extensive studies have not been performed.The 3'-untranslated region(3'-UTR)of tho GATA4 gene comprises regulatory motifs and microRNA binding sites that are critical for the appropriate gene expression,nuclear transportation,and regulation of translation,and stability of mRNA.This study aimed to evaluate the association between mutations in the 3'-UTR of the GATA4 gene and CHD risk among Iranian patients.展开更多
文摘This study aimed to evaluate the correlation between nursing informatics(NI)competency and information literacy skills for evidencebased practice(EBP)among intensive care nurses.This cross-sectional study was conducted on 184 nurses working in intensive care units(ICUs).The study data were collected through demographic information,Nursing Informatics Competency Assessment Tool(NICAT),and information literacy skills for EBP questionnaires.The intensive care nurses received competent and low-moderate levels for the total scores of NI competency and information literacy skills,respectively.They received a moderate score for the use of different information resources but a low score for information searching skills,different search features,and knowledge about search operators,and only 31.5%of the nurses selected the most appropriate statement.NI competency and related subscales had a significant direct bidirectional correlation with information literacy skills for EBP and its subscales(P<0.05).Nurses require a high level of NI competency and information literacy for EBP to obtain up-to-date information and provide better care and decision-making.Health planners and policymakers should develop interventions to enhance NI competency and information literacy skills among nurses and motivate them to use EBP in clinical settings.
文摘Cancer is one of the main challenges of the health system around the world.This disease is increasing in developing countries and imposes heavy costs on patients and governments.On the other hand,despite various drugs,the death rate among cancer patients is still high and the current treatments have many harmful effects.In the traditional medicine of different countries,there are many medicinal plants that can be effective in the treatment of cancer.Ferula plants are traditionally used as spices and food or for medicinal purposes.Ferula assa-foetida is one of the famous plants of this genus,which has been used for the treatment of various diseases since ancient times.Among the main compounds of this plant,we can mention monoterpenes,sulfide compounds and polyphenols,which can show different therapeutic effects.This article has been compiled with the aim of collecting evidence and articles related to the anti-cancer effects of extracts,derived compounds,essential oils and nanoparticles containing Ferula assa-foetida.This review article was prepared by searching the terms Ferula assa-foetida and cancer,and relevant information was collected through searching electronic databases such as ISI Web of Knowledge,PubMed,and Google Scholar.Fortunately,the results of this review showed that relatively comprehensive studies have been conducted in this field and shown that Ferula assa-foetida can be very promising in the treatment of cancer.
文摘Objective:To elucidate the possible role of unfractionated heparin in patients with failed repeated in in vitro fertilization and embryo transfer(IVF-ET)and thrombophilia.Methods:This case control study evaluated the efficacy of the unfractionated heparin in increasing the pregnancy and implantation ratio in women with recurrent IVF-ET failures.Eighty-six women received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)with a record of three or more previous IVF-ET failures.Participants were randomly distributed into two groups.Group A(n=43)received unfractionated heparin 5000 IU twice daily,and group B(n=43)did not take any antithrombotic drugs.Coagulation abnormalities such as factor桋Leiden(FVL)mutation,methylene tetra hydro folate reductase(MTHFR)mutation and prothrombin mutation(F栻)were evaluated.Age,body mass index,basal follicular stimulating hormone,basal estradiol,duration of infertility,and number of IVF-ET failures were compared between two groups.Results:45.0%and 17.4%of women were pregnant with and without MTHFR and prothrombin mutation,respectively,when they received unfractionated heparin treatment.The implantation rate was more in group A(12.5%)than group B(4.3%)and differences in the fertilization rate of the two groups were observed(27.7%vs.35.9%).The clinical pregnancy rate per cycle was remarkably more in group A(30.2%)than group B(14.0%).Conclusions:Heparin is a safe and valuable treatment for patients with repeated IVF-ET failures.The clinical pregnancy and implantation rates are higher in the heparin-treated group in contrast with the control group.
基金the Clinical Research Development Center of Taleghani and Imam Ali Hospital, University of Medical Sciences, Kermanshah, IranShohada Tajrish Clinical Research Development Center at Shahid Beheshti University of Medical Sciences in Tehran, Iran, for their support。
文摘BACKGROUND It has been said that the number of orthopaedic claims has increased in the last few years. Investigation through the most prevalent cause would help to prevent further cases.AIM To review the cases of medical complaints in orthopedic patients who had been involved in a traumatic accident.METHODS A retrospective multi-center review of trauma orthopaedic-related malpractice lawsuits from 2010 to 2021 was conducted utilizing the regional medicolegal database. Defendant and plaintiff characteristics along with fracture location, allegations, and litigation outcomes were investigated.RESULTS A total of 228 claims referred to trauma-related conditions with a mean age of 31.29 ± 12.56 were enrolled. The most common injuries were at hand, thigh, elbow, and forearm, respectively.Likewise, the most common alleged complication was related to malunion or nonunion. In 47% of the cases, the main problem that led to the complaint was the inappropriate or insufficient explanation to the patient, and in 53%, there was a problem in the surgery. Eventually, 76% of the complaints resulted in a defense verdict, and 24% resulted in a plaintiff verdict.CONCLUSION Surgical treatment of hand injuries and surgery in non-educational hospitals received the most complaints. The majority of litigation outcomes were caused by a physician’s failure to fully explain and educate the traumatic orthopedic patients and technological errors.
基金supported by research center from Shahid Sadoughi University of Medical Sciences,Yazd,Iran
文摘To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.
文摘BACKGROUND: Bile duct ligation(BDL) and subsequent cholestasis are correlated with oxidative stress, hepatocellular injury and fibrosis. Quercetin is a flavonoid with antifibrotic,and hepatoprotective properties. However, the molecular mechanism underlying quercetin-mediated hepatoprotection is not fully understood. The current study was to evaluate mechanisms of hepatoprotective effect of quercetin in BDL rat model.METHODS: We divided male Wistar rats into 4 groups(n=8 for each): sham, sham+quercetin(30 mg/kg per day), BDL, and BDL+quercetin(30 mg/kg per day). Four weeks later, the rats were sacrificed, the blood was collected for liver enzyme measurements and liver for the measurement of Rac1, Rac1-GTP and NOX1 mR NA and protein levels by quantitative PCR and Western blotting, respectively.RESULTS: Quercetin significantly alleviated liver injury in BDL rats as evidenced by histology and reduced liver enzymes.Furthermore, the m RNA and protein expression of Rac1,Rac1-GTP and NOX1 were significantly increased in BDL rats compared with those in the sham group(P<0.05); quercetin treatment reversed these variables back toward normal(P<0.05). Another interesting finding was that the antioxidant markers e.g. superoxide dismutase and catalase were elevated in quercetin-treated BDL rats compared to BDL rats(P<0.05).CONCLUSION: Quercetin demonstrated hepatoprotective activity against BDL-induced liver injury through increasing antioxidant capacity of the liver tissue, while preventing the production of Rac1, Rac1-GTP and NOX1 proteins.
基金financially supported by Research Deputy,Shahid Sadoughi University of Medical Sciences,Yazd,Iran,with project No.P/17/1/19412
文摘Objective: To investigate and predict the effects of climate change on the potential distribution of the main vector and reservoir hosts of the disease in Yazd province in the future.Methods: Distribution data for vector and reservoir hosts of zoonotic cutaneous leishmaniasis in Yazd province were obtained from earlier studies conducted in the area.MaxEnt ecological niche modeling was used to predict environmental suitability.BCC-CSM1-1(m) model and two climate change scenarios, RCP 4.5 and RCP 8.5 were used for horizons 2030 and 2050 climate projections.Future projections were based on data of a regional climate change model.Results: With both scenarios in 2030 and 2050, the results of jackknife test indicated that the mean temperature of wettest quarter and temperature annual range had the greatest effect on the model for the vector and the reservoir hosts, respectively.Conclusions: The climate conditions are the major determinants of zoonotic cutaneous leishmaniasis incidence rate in Yazd Province.These climate conditions provide favorable habitats for ease transmission of zoonotic cutaneous leishmaniasis in this endemic area.Habitats suitability for the vector and reservoir will be expanding in the coming years compared with the current conditions, such that, in horizon 2030 & 2050, the probability of the presence of the vector and reservoir within 38 580 and 37 949 km^2, respectively, from Yazd province is above 60%.Moreover, an increase is predicted in the presence of the vector in the western parts and the reservoir in the northern and central parts of the province in the future.Understanding the role of environmental and bioclimatic factors in zoonotic cutaneous leishmaniasis occurrence can provide a guide for policy-makers in the creation and implementation of more effective policies for prevention and control.
文摘Objective:To determine the temporal patterns of cumulative incidence of brucellosis using autoregressive integrated moving average models.Methods:This cross-sectional study employed yearly and monthly data of 1117 laboratory-confirmed human brucellosis cases from January 2013 to December 2018 using the Yazd brucellosis national surveillance system.The monthly incidences constructed a timeseries model.The trend of cumulative incidence was perceived by tracing a line plot,which displayed a seasonal trend with periodicity.Thus,the ARIMA models were selected.Thereafter,Akaike information criteria(AIC)and Bayesian information criterion(BIC)values among different models indicated a preferable model from models which were expanded by diverse lags[(3,0,3),(2,0,3),(3,0,2),(4,0,3)and(3,0,4)].Then,the achieved ARIMA model was applied to the forecasting cumulative incidence of monthly brucellosis incidences.All analyses were performed using Stata,version 11.2.Results:For the ARIMA(3,0,4)model,MAPE value was 56.20%with standard error 0.009–0.016,and white noise diagnostic check(Q=19.79,P=0.975)for the residuals of the selected model showed that the data were completely modelled.The monthly incidences that were fitted by the ARIMA(3,0,4)model,with AIC(25.7)and BIC(43.35)with a similar pattern of actual cases from 2013 to 2018 and forecasting incidences from January 2019 to December 2019 were,respectively,0.50,0.44,0.45,0.49,0.55,0.58,0.56,0.51,0.46,0.44,0.45 and 0.49 per 100000 people.Conclusions:In summary,the study showed that the ARIMA(3,0,4)model can be applied to forecast human brucellosis patterns in Yazd province,supplementing present surveillance systems,and may be better for health policy-makers and planners.
文摘Objective:To investigate the epidemiological pattern of animal bites in Yazd Province,central Iran.Methods:In this cross-sectional study,8 545 individuals with animal bites who were referred to the Yazd Province Rabies Treatment Center were investigated using the census method from April 2013 to March 2017.The variables included:demographic information,household living condition,the type of biting animals,the domesticated and wild animals,the time of biting based on year,the residence location (urban or rural),and the treatment status.Data were analyzed by descriptive statistics using Excel 2013,SPSS version 25 and Arc GIS 14.1 Software.Results:A total of 8 545 cases of animal bites were reported in Yazd province from 2013 to 2017.The most animal bites (with 4 253 case of bites) and the lowest animal bites (with 121 case of bites) occurred in Yazd and Bahabad district,respectively.The incidence of animal bites was 168.4 per 100 000 people during the five-year period.Most of cases (73.9%) occurred in urban areas.Dog and cat bites accounted for 47.6% and 47.4% of all cases,respectively.Most of animal bites were reported in the summer (29.4%).Sixty percent of the cases received incomplete treatments,while 40% of them received complete treatments.During this study,three positive cases of fatal rabies from dog bites were reported.Conclusions:The incidence of animal bites is high in Yazd province,and more patients are bitten by dog and cat.Hence,educational,preventive,and informative programs are required to reduce the incidence of animal bites.
文摘Objectives:To investigate the epidemiology of animal bites and associated factors in Abadeh district(central Iran)from 2012 to 2018.Methods:In this cross-sectional study,1407 individuals with animal bites who were referred to the Abadeh Rabies Treatment Center were investigated by using the census method from 2012 to 2018.The variables included the victim's demographic information(age,gender,occupation),the type of biting animals(dog,cat,and other animals),the domesticated and wild animals,the time of biting based on year and month,the residence location(urban or rural),the treatment status,and the anatomical location of the wounds.Results:The annual incidence rate of animal bites was 189.62 per 100000 population.Totally 83.4%of the victims were male.The average age was(33.66±18.97)years and individuals in the age range of 36-50 years were greater at risk.Most of the animal bites were from dogs(77.8%).About two thirds(62.1%)of the bites were from household animals.A total of 57.1%of individuals lived in urban areas.Most victims were engaged in farming and animal husbandry.The highest prevalence of animal bites(37.4%)happened in the summer.None of the patients had any clinical signs of rabies.Conclusions:To reduce the incidence of animal bites,high-risk groups including farmers and ranchers should be educated about bite prevention,and it should be ensured that they are managed correctly.
文摘Background: Pulp stones are calcified masses formed in the primary and permanent dentitions. The ischemic cardiovascular disorders (CVD) can be the first health problem of the world. It seems that there is a relationship between pulp stones and cardiovascular diseases to determine the diagnostic value of panoramic dental radiographs as non-invasive test for the early detection of CVD. Methods and Materials: The subjects of the study came from patients presenting to Dental Radiology Department of Dental School in Yazd who aged 30 - 64 years, had 8 natural teeth. They were referred to the Cardiovascular Center of Afshar Hospital in Yazd for cardiovascular evaluation. To set the cut-off point, the ratio of teeth with pulp stones to the total number of teeth for each person was calculated and also ABI for diagnosing IHD via ROC curve was used. Results: Only 3.8% of patients without pulp stone were affected by ischemic heart disease (IHD). About Sixty seven percent (67.3%) of individuals had at least one tooth with pulp stone. In individuals without IHD, 5% of the teeth showed pulp stone while this rate was 45% (9 times) in CVD patients. The number of patients for whom the ratio of teeth with pulp stone to total number of teeth was 0.2 or more, was 138.7 times greater than the other. Conclusion: The dentists, who order panoramic radiographs for the treatment of patients, exactly study those teeth for the presence of pulp stones. The ratio of teeth with pulp stone to total teeth equal 0.2 or more was a good tool for early detection of CVD.
文摘The used water for human consumption must be free of microorganisms and chemicals that cause risk in the human health. In this study, water quality of 18 rural area of Abarkouh was determined and compared the conventional monitoring method (According to ISIR (Institute of Standards and Industrial Research of Iran), 1053 and 4208) and use of electronic system method (Patent in industrial property general office of Iran, 77815). Free chlorine monitoring and pH test done by health workers in the conventional method and the results will be sent to the Health Network monthly. Sampling for microbiological testing is done monthly based on population (According to ISIR, 4208). On the electronic system, the procedure is also done by health workers, but the result will be sent to the receiver device by using a cell phone. According to the chlorine test results if the free chlorine residual reported zero, microbiological sampling was done by a health expert. Finally, the number of chlorine test and microbiological sampling and the results of these experiments collected in the both methods and recorded in SPSS 22 then were analyzed by using chi-square test and Fisher exact test. The result of microbiological experiments shows that the sampling rate decreased 29% in using of electronic system method in comparison to the conventional monitoring method while the number of microbial defect detection increased 19% in drinking water networks monitoring by electronic system. Using of electronic system monitoring can reduce the rate and cost of microbiological sampling and its experiments and increase accuracy of these tests, in this way it will increase the quality and safety of drinking water in distribution network in small and dispersed rural communities.
文摘Objectives: Considering the growing need for using a variety of new nonpharmacological methods in treating depression, this quasi experimental study was conducted to investigate the effect of aerobic indoor exercise in a gym compared with green exercise in an outdoor green environment of an urban park on triple categories of affective, cognitive and somatic symptoms of depression and to examine its psychological mediators of perceived stress and coping strategies. Methods: Forty six female outpatients with major depressive disorder were divided into 3 conditions of indoor exercise + routine pharmacotherapy (n = 15), green exercise + routine pharmacotherapy (n = 15), and a routine pharmacotherapy alone as the control group (n = 16). The exercise used for both indoor and green exercise conditions consisted of 36 one hour sessions (three times per week) with an intensity of 50% - 70% of the maximum heart rate. The participants completed the pre- and post-intervention depression, stress and coping questionnaires including Beck Depression Inventory-II, Perceived Stress Scale and Coping Inventory for Stressful Situations. Results: The findings indicated a significant decrease in the post-intervention scores of all three categories of affective, cognitive and somatic symptoms of depression and perceived stress in both exercise groups compared with the control group, but there was no significant difference between two exercise groups. With respect to the use of problem-focused, emotion-focused and avoidant-focused coping methods, there was no significant difference between post-intervention scores of all groups. Conclusion: In the clinical settings, both of the indoor exercise and green exercise programs can help to further improvement in all three categories of affective, cognitive and somatic symptoms of depression as an adjunct (or independent) treatment to the same degree, especially mediated by reducing the amount of perceived stress, but not through any significant changes in cognitive-behavioral coping strategies.
基金The authors would like to thank the Laboratory of Water Engineering,Fasa University for providing the facilities to perform this research.
文摘Groundwater is considered as one of the most important sources for water supply in Iran.The Fasa Plain in Fars Province,Southern Iran is one of the major areas of wheat production using groundwater for irrigation.A large population also uses local groundwater for drinking purposes.Therefore,in this study,this plain was selected to assess the spatial variability of groundwater quality and also to identify main parameters affecting the water quality using multivariate statistical techniques such as Cluster Analysis(CA),Discriminant Analysis(DA),and Principal Component Analysis(PCA).Water quality data was monitored at 22 different wells,for five years(2009-2014)with 10 water quality parameters.By using cluster analysis,the sampling wells were grouped into two clusters with distinct water qualities at different locations.The Lasso Discriminant Analysis(LDA)technique was used to assess the spatial variability of water quality.Based on the results,all of the variables except sodium absorption ratio(SAR)are effective in the LDA model with all variables affording 92.80%correct assignation to discriminate between the clusters from the primary 10 variables.Principal component(PC)analysis and factor analysis reduced the complex data matrix into two main components,accounting for more than 95.93%of the total variance.The first PC contained the parameters of TH,Ca2+,and Mg2+.Therefore,the first dominant factor was hardness.In the second PC,Cl-,SAR,and Na+were the dominant parameters,which may indicate salinity.The originally acquired factors illustrate natural(existence of geological formations)and anthropogenic(improper disposal of domestic and agricultural wastes)factors which affect the groundwater quality.
文摘Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil;2) consume 20 ml/day grape seed oil;3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.
文摘BACKGROUND:Numerous drugs have been proposed to alleviate pain in patients with biliary colic,especially opioids,but still there is a tendency to use less narcotics because of their side effects and the unwillingness of some patients.The present study aimed to compare the analgesic effect of paracetamol combined with low-dose morphine versus morphine alone in patients with biliary colic.METHODS:A randomized double-blind controlled trial was performed in 98 patients with biliary colic,recruited from two emergency departments from August 2012 to August 2013.Eleven patients were excluded and the remaining were randomized into two groups:group A received 0.05mg/kg morphine+1 000 mg paracetamol in 100 m L normal saline and group B received 0.1 mg/kg morphine+normal saline(100 m L)as placebo.Pain scores were recorded using visual analogue scale(VAS)at baseline and 15 and 30 minutes after drug administration.Adverse effects and the need for rescue medication(0.75 g/kg intravenous fentanyl)were also reported within 60 minutes of drug administration.RESULTS:Before the infusion,the mean±SD VAS scores were 8.73±1.57 in group A and8.53±1.99 in group B.At 15 minutes after drug administration,the mean±SD VAS scores were2.16±1.90 in group A vs.2.51±1.86 in group B;mean difference was–0.35,and 95%CI–1.15 to 0.45(P=0.38).At 30 minutes the mean±SD VAS scores were 1.66±1.59 in group A vs.2.14±1.79 in group B;mean difference was–0.48,and 95%CI–1.20 to 0.24(P=0.19).The mean pain scores in the two groups at 15 and 30 minutes demonstrated no significant difference.CONCLUSION:Paracetamol combined with low-dose morphine may be effective for pain management in patients with biliary colic.
基金the authorities of Shahid Sadoughi University of Medical Sciences for their financial support and assistance
文摘Objective:To determine the rate of carcass and offal condemnation in the animals slaughtered at Yazd slaughterhouse,Yazd,Iran.Methods:In a nine-month retrospective survey from June 2011 to March 2012,all the carcasses and offal condemnations for large animals(cattle and camels) and small animals(sheep and goats)in Yazd Slaughterhouse were carefully recorded daily.Results:In total,2741 large animals(cattle and camels) and 77515 small animals(sheep and goats) were slaughtered during the period of this survey.Six carcasses(0.21%) of the large animals and 18 carcasses(0.02%) of the small animals were condemned.For large animals,condemnations in summer and autumn were significantly greater than winter(P<0.05).Condemnation rate of liver,lungs and kidneys for the large animals were 5.36%,21.23%and 3.68%respectively and for the small animals were 4.37%,5.46%and 0.51%respectively.The main recorded reasons for carcass condemnations in both large and small animals were icterus and cachexia.The most prevalent lesion resulting in offal condemnation was due to parasitic infection specially metacestods.Conclusions:This study aimed to show the efficiency of documentation records during meal inspection at slaughterhouses to monitor the amount of condemnation and possible approaches to better awareness about the future preventive programs.Considering the percentage of condemnation of carcass and offal in the present study and their price in Iranian markets,the overall economic losses seems to be notable at Yazd slaughterhouse.
文摘Background:Several studies have tried to evaluate the effects of stem cell therapy for spinal cord injury in animal models and human trials.Bone marrow mesenchymal stem cells are one of the safe and available candidate cells with established beneficial therapeutic effects for bone and cartilage repair.However,there are some doubts regarding their therapeutic efficacy for nervous system disorders.Bone marrow mesenchymal stem cells have been used in some clinical trials for spinal cord injury but their precise mechanism of action and also their safety has not been investigated.Available experimental reports do not provide sufficient and convincing evidence to persuade therapists to perform further clinical trials.In the present study we have used detailed staining methods to clearly show the entire structure of the injured spinal cord and the effects of bone marrow mesenchymal stem cells treatment on this tissue.Methods:Intrathecal injection of neutral red stained bone marrow mesenchymal stem cells were done in a rat model of spinal cord injury and the fate of the transplanted cells,immunologic responses in the host tissue,and tumor generation were assessed by using brightfield and fluorescence microscopy.Sensory-motor functions were also evaluated in the animals.Results:Injected cells could migrate to the site of the injury and differentiate into oligodendrocytes and astrocytes.Immuno-histological assays showed no cells expressing CD2,CD3,CD15 and CD45 in host tissues,and sensory-motor assessments revealed that there were some partial improvements.Conclusion:Present study provides strong evidence that mesenchymal stem cell therapy is safe and could be helpful for the remyelination of injured nerve fibers in the acute phase of injury.
文摘Objective:Transcription factor GATA4 has significant roles in embryonic heart development.Mutations of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of GATA4 mutations in CHD phenotypes,extensive studies have not been performed.The 3'-untranslated region(3'-UTR)of tho GATA4 gene comprises regulatory motifs and microRNA binding sites that are critical for the appropriate gene expression,nuclear transportation,and regulation of translation,and stability of mRNA.This study aimed to evaluate the association between mutations in the 3'-UTR of the GATA4 gene and CHD risk among Iranian patients.
