Flexible surface acoustic wave(SAW)devices have recently attracted tremendous attention for their widespread application in sensing and microfluidics.However,for these applications,SAW devices often need to be bent in...Flexible surface acoustic wave(SAW)devices have recently attracted tremendous attention for their widespread application in sensing and microfluidics.However,for these applications,SAW devices often need to be bent into offaxis deformations between the acoustic wave propagation direction and bending direction.Currently,there are few studies on this topic,and the bending mechanisms during off-axis bending deformations have remained unexplored for multisensing applications.Herein,we fabricated aluminum nitride(AlN)flexible SAW devices by using high-quality AlN films deposited on flexible glass substrates and systematically investigated their complex deformation behaviors.A theoretical model was first developed using coupling wave equations and the boundary condition method to analyze the characteristics of the device with bending and off-axis deformation under elastic strains.The relationships between the frequency shifts of the SAW device and the bending strain and off-axis angle were obtained,and the results were identical to those from the theoretical calculations.Finally,we performed proof-of-concept demonstrations of its multisensing potential by monitoring human wrist movements at various off-axis angles and detecting UV light intensities on a curved surface,thus paving the way for the application of versatile flexible electronics.展开更多
Liver is the foremost organ of human being for drug metabolism,and it played a significant role in toxicity evaluation of drugs.Establishing a liver model in vitro can accelerate the process of the drug screening and ...Liver is the foremost organ of human being for drug metabolism,and it played a significant role in toxicity evaluation of drugs.Establishing a liver model in vitro can accelerate the process of the drug screening and new drug research and development.We provide a 3D printing based hepatic sinusoid-on-a-chip microdevice that reconstitutes organ-level liver functions to create a drug screening model of toxicity evaluation on chip.The microfluidic device,which recapitulates the hepatic sinusoid microenvironment,consists of PET polyporous membranes which mimic the perisinusoidal space,and experience fluid flow to mimic the hepatic arterial capillaries.The PET membrane was used to separate the hepatocyte and endotheliocyte.The endotheliocyte was cultured on the downside of the membrane and the hepatocyte were 3D seeded on the membrane via the 3D printer.This device was used to reproduce the in vitro liver model for drug toxicity assays.The expression of several biomarkers of liver was compared with the monoculture and 2D cultured conditions,and the results reveal that this organ-on-a-chip microdevice mimics the drug hepatoxicity that has not been possible by 2D cell-based and animal models,providing a useful platform for screening the drugs and developing an effective therapy in hepatopathy.展开更多
There are great concerns for sensing using flexible acoustic wave sensors and lab-on-a-chip,as mechanical strains will dramatically change the sensing signals(e.g.,frequency)when they are bent during measurements.Thes...There are great concerns for sensing using flexible acoustic wave sensors and lab-on-a-chip,as mechanical strains will dramatically change the sensing signals(e.g.,frequency)when they are bent during measurements.These strain-induced signal changes cannot be easily separated from those of real sensing signals(e.g.,humidity,ultraviolet,or gas/biological molecules).Herein,we proposed a new strategy to minimize/eliminate the effects of mechanical bending strains by optimizing off-axis angles between the direction of bending deformation and propagation of acoustic waves on curved surfaces of layered piezoelectric film/flexible glass structure.This strategy has theoretically been proved by optimization of bending designs of off-axis angles and acoustically elastic effect.Proof-of-concept for humidity and ultraviolet-light sensing using flexible SAW devices with negligible interferences are achieved within a wide range of bending strains.This work provides the best solution for achieving high-performance flexible acoustic wave sensors under deformed/bending conditions.展开更多
基金This work was supported by the General Program of the National Natural Science Foundation of China(NSFC No.52075162)the Innovation Leading Program of New and High-tech Industry of Hunan Province(2020GK2015)+5 种基金The Natural Science Foundation of Hunan Province(2021JJ20018)the Natural Science Foundation of Changsha(kq2007026)the Key Research Project of Guangdong Province(2020B0101040002)NSFC-Zhejiang Joint Fund for the Integration of Industrialization anf information(No.U20A20172,U1909212)the Engineering Physics and Science Research Council of UK(EPSRC EP/P018998/1)the International Exchange Grant(IEC/NSFC/201078)through the Royal Society and NSFC.
文摘Flexible surface acoustic wave(SAW)devices have recently attracted tremendous attention for their widespread application in sensing and microfluidics.However,for these applications,SAW devices often need to be bent into offaxis deformations between the acoustic wave propagation direction and bending direction.Currently,there are few studies on this topic,and the bending mechanisms during off-axis bending deformations have remained unexplored for multisensing applications.Herein,we fabricated aluminum nitride(AlN)flexible SAW devices by using high-quality AlN films deposited on flexible glass substrates and systematically investigated their complex deformation behaviors.A theoretical model was first developed using coupling wave equations and the boundary condition method to analyze the characteristics of the device with bending and off-axis deformation under elastic strains.The relationships between the frequency shifts of the SAW device and the bending strain and off-axis angle were obtained,and the results were identical to those from the theoretical calculations.Finally,we performed proof-of-concept demonstrations of its multisensing potential by monitoring human wrist movements at various off-axis angles and detecting UV light intensities on a curved surface,thus paving the way for the application of versatile flexible electronics.
基金The National Key R&D Program of China(No.2018YFA0108202)National Science Foundation,China(Nos.61971410,61801464,62001458 and 61801465)+3 种基金Shanghai Sailing Program(No.20YF1457100)China Postdoctoal Science Foundation(No.2020000246)Shanghai Engineer&Technology Research Center of Internet of Things for Respiratory Medicine(No.20DZ2254400)the Science and Technology Commission of Shanghai Municipality(No.19511104200)。
文摘Liver is the foremost organ of human being for drug metabolism,and it played a significant role in toxicity evaluation of drugs.Establishing a liver model in vitro can accelerate the process of the drug screening and new drug research and development.We provide a 3D printing based hepatic sinusoid-on-a-chip microdevice that reconstitutes organ-level liver functions to create a drug screening model of toxicity evaluation on chip.The microfluidic device,which recapitulates the hepatic sinusoid microenvironment,consists of PET polyporous membranes which mimic the perisinusoidal space,and experience fluid flow to mimic the hepatic arterial capillaries.The PET membrane was used to separate the hepatocyte and endotheliocyte.The endotheliocyte was cultured on the downside of the membrane and the hepatocyte were 3D seeded on the membrane via the 3D printer.This device was used to reproduce the in vitro liver model for drug toxicity assays.The expression of several biomarkers of liver was compared with the monoculture and 2D cultured conditions,and the results reveal that this organ-on-a-chip microdevice mimics the drug hepatoxicity that has not been possible by 2D cell-based and animal models,providing a useful platform for screening the drugs and developing an effective therapy in hepatopathy.
基金supported by the Excellent Youth Fund of Hunan Province (2021JJ20018)the NSFC (No.52075162)+3 种基金the Program of New and High-tech Industry of Hunan Province (2020GK2015,2021GK4014)the Joint Fund Project of the Ministry of Educationthe Engineering Physics and Science Research Council of UK (EPSRC EP/P018998/1)International Exchange Grant (IEC/NSFC/201078)through Royal Society and the NSFC.
文摘There are great concerns for sensing using flexible acoustic wave sensors and lab-on-a-chip,as mechanical strains will dramatically change the sensing signals(e.g.,frequency)when they are bent during measurements.These strain-induced signal changes cannot be easily separated from those of real sensing signals(e.g.,humidity,ultraviolet,or gas/biological molecules).Herein,we proposed a new strategy to minimize/eliminate the effects of mechanical bending strains by optimizing off-axis angles between the direction of bending deformation and propagation of acoustic waves on curved surfaces of layered piezoelectric film/flexible glass structure.This strategy has theoretically been proved by optimization of bending designs of off-axis angles and acoustically elastic effect.Proof-of-concept for humidity and ultraviolet-light sensing using flexible SAW devices with negligible interferences are achieved within a wide range of bending strains.This work provides the best solution for achieving high-performance flexible acoustic wave sensors under deformed/bending conditions.
