The population aged 60 and over in China reached approximately 297 million in 2023 according to the National Bureau of Statistics,accounting for 21.1%of the national population.The population aged 65 and over was abou...The population aged 60 and over in China reached approximately 297 million in 2023 according to the National Bureau of Statistics,accounting for 21.1%of the national population.The population aged 65 and over was about 217 million,accounting for 15.4%[1].It is estimated that by 2035,China will have an elderly population of over 400 million,accounting for more than 30%of the total population,thereby entering a stage of severe aging.Aging brings many challenges to the society,especially in terms of medical care for elderly patients.The continuous advancement of science and technology,especially the breakthrough in basic research as well as new technologies and interdisciplinary integration,has brought new opportunities for the development of various professional fields.To better address the challenges of anesthesia and perioperative medicine in the aging era and to accelerate the rehabilitation of patients while maintaining life and health services,it is crucial to promote interdisciplinary integration.展开更多
Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome ...Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome radioresistance due to the feedback mechanisms initiated by tumor cells under radiotherapy.Therefore,we herein developed an engineering biomimetic nanosystem(M@HHPt)masked with tumor cell membranes and loaded with a hybridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target multiple tumor radioresistance hallmarks for enhanced radiotherapy.After administration,M@HHPt actively targeted and smoothly accumulated in tumor cells by virtue of its innate homing abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced hypoxia alleviation cooperated with Pt(Ⅳ)reduction caused glutathione consumption greatly amplified radiotherapy-ignited cellular oxidative stress.Moreover,the released cisplatin effectively hindered DNA damage repair by crosslinking with radiotherapy-produced DNA fragments.Consequently,M@HHPt-sensitized radiotherapy significantly suppressed the proliferation of lung cancer H1975 cells with an extremely high sensitizer enhancement ratio of 1.91 and the progression of H1975 tumor models with an excellent tumor inhibition rate of 94.7%.Overall,this work provided a feasible strategy for tumor radiosensitization by overcoming multiple radioresistance mechanisms.展开更多
文摘The population aged 60 and over in China reached approximately 297 million in 2023 according to the National Bureau of Statistics,accounting for 21.1%of the national population.The population aged 65 and over was about 217 million,accounting for 15.4%[1].It is estimated that by 2035,China will have an elderly population of over 400 million,accounting for more than 30%of the total population,thereby entering a stage of severe aging.Aging brings many challenges to the society,especially in terms of medical care for elderly patients.The continuous advancement of science and technology,especially the breakthrough in basic research as well as new technologies and interdisciplinary integration,has brought new opportunities for the development of various professional fields.To better address the challenges of anesthesia and perioperative medicine in the aging era and to accelerate the rehabilitation of patients while maintaining life and health services,it is crucial to promote interdisciplinary integration.
基金supported by the National Science Fund for Distinguished Young Scholars of China(82225026)the National Natural Science Foundation of China(82172082)CAMS Innovation Fund for Medical Sciences(2021-I2M-1-042,2023-I2M-QJ-016)。
文摘Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist radiotherapy.Targeting one of these features is insufficient to overcome radioresistance due to the feedback mechanisms initiated by tumor cells under radiotherapy.Therefore,we herein developed an engineering biomimetic nanosystem(M@HHPt)masked with tumor cell membranes and loaded with a hybridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target multiple tumor radioresistance hallmarks for enhanced radiotherapy.After administration,M@HHPt actively targeted and smoothly accumulated in tumor cells by virtue of its innate homing abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced hypoxia alleviation cooperated with Pt(Ⅳ)reduction caused glutathione consumption greatly amplified radiotherapy-ignited cellular oxidative stress.Moreover,the released cisplatin effectively hindered DNA damage repair by crosslinking with radiotherapy-produced DNA fragments.Consequently,M@HHPt-sensitized radiotherapy significantly suppressed the proliferation of lung cancer H1975 cells with an extremely high sensitizer enhancement ratio of 1.91 and the progression of H1975 tumor models with an excellent tumor inhibition rate of 94.7%.Overall,this work provided a feasible strategy for tumor radiosensitization by overcoming multiple radioresistance mechanisms.
