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Coexistence behavior of asymmetric attractors in hyperbolic-type memristive Hopfield neural network and its application in image encryption
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作者 李晓霞 何倩倩 +2 位作者 余天意 才壮 徐桂芝 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期302-315,共14页
The neuron model has been widely employed in neural-morphic computing systems and chaotic circuits.This study aims to develop a novel circuit simulation of a three-neuron Hopfield neural network(HNN)with coupled hyper... The neuron model has been widely employed in neural-morphic computing systems and chaotic circuits.This study aims to develop a novel circuit simulation of a three-neuron Hopfield neural network(HNN)with coupled hyperbolic memristors through the modification of a single coupling connection weight.The bistable mode of the hyperbolic memristive HNN(mHNN),characterized by the coexistence of asymmetric chaos and periodic attractors,is effectively demonstrated through the utilization of conventional nonlinear analysis techniques.These techniques include bifurcation diagrams,two-parameter maximum Lyapunov exponent plots,local attractor basins,and phase trajectory diagrams.Moreover,an encryption technique for color images is devised by leveraging the mHNN model and asymmetric structural attractors.This method demonstrates significant benefits in correlation,information entropy,and resistance to differential attacks,providing strong evidence for its effectiveness in encryption.Additionally,an improved modular circuit design method is employed to create the analog equivalent circuit of the memristive HNN.The correctness of the circuit design is confirmed through Multisim simulations,which align with numerical simulations conducted in Matlab. 展开更多
关键词 hyperbolic-type memristor Hopfield neural network(HNN) asymmetric attractors image encryption
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Microstructure,Properties and Crack Suppression Mechanism of High-speed Steel Fabricated by Selective Laser Melting at Different Process Parameters
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作者 Wenbin Ji Chuncheng Liu +1 位作者 Shijie Dai Riqing Deng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第2期91-105,共15页
To enrich material types applied to additive manufacturing and enlarge application scope of additive manufacturing in conformal cooling tools,M2 high-speed steel specimens were fabricated by selective laser melting(SL... To enrich material types applied to additive manufacturing and enlarge application scope of additive manufacturing in conformal cooling tools,M2 high-speed steel specimens were fabricated by selective laser melting(SLM).Effects of SLM parameters on the microstructure and mechanical properties of M2 high-speed steel were investigated.The results showed that substrate temperature and energy density had significant influence on the densification process of materials and defects control.Models to evaluate the effect of substrate temperature and energy density on hardness were studied.The optimized process parameters,laser power,scan speed,scan distance,and substrate temperature,for fabricated M2 are 220 W,960 mm/s,0.06 mm,and 200℃,respectively.Based on this,the hardness and tensile strength reached 60 HRC and 1000 MPa,respectively.Interlaminar crack formation and suppression mechanism and the relationship between temperature gradient and thermal stress were illustrated.The inhibition effect of substrate temperature on the cracks generated by residual stresses was also explained.AM showed great application potential in the field of special conformal cooling cutting tool preparation. 展开更多
关键词 Selective laser melting High-speed steel Mechanical properties MICROSTRUCTURE Interlaminar cracks
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Design Optimization of a Novel Axial-radial Flux Permanent Magnet Claw Pole Machine with SMC Cores and Ferrite Magnets
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作者 Chengcheng Liu Fan Yang +1 位作者 Wenfeng Zhang Youhua Wang 《CES Transactions on Electrical Machines and Systems》 CSCD 2023年第4期358-365,共8页
Soft magnetic composite(SMC)material is an ideal soft magnetic material employed for developing 3D magnetic flux electromagnetic equipment,due to its advantages of 3D magnetic isotropy characteristic,low eddy current ... Soft magnetic composite(SMC)material is an ideal soft magnetic material employed for developing 3D magnetic flux electromagnetic equipment,due to its advantages of 3D magnetic isotropy characteristic,low eddy current loss,and simple manufacturing process.The permanent magnet claw pole machine(PMCPM)with SMC cores is a good case that the SMC to be adopted for developing 3D flux electrical machines.In this paper,a novel axial-radial flux permanent magnet claw pole machine(ARPMCPM)with SMC cores and ferrite magnets is proposed.Compared with the traditional PMCPM,the proposed ARPMCPM is designed with only one spoke PM rotor and its whole structure is quite compact.For the performance prediction,the 3D finite element method(FEM)is used.Meanwhile,for the performance evaluation,a previously developed axial flux claw pole permanent magnet machine(AFCPM)is employed as the benchmark machine and all these machines are optimized by using the combined multilevel robust Taguchi method.It can be seen that the proposed ARPMCPM is with higher torque/weight density and operation efficiency. 展开更多
关键词 Soft magnetic composite(SMC) Permanent magnetic claw pole machine(PMCPM) Axial-radial flux
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Design and Performance Analysis of Permanent Magnet Claw Pole Machine with Hybrid Cores
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作者 Chengcheng Liu Zheng Chao +1 位作者 Shaopeng Wang Youhua Wang 《CES Transactions on Electrical Machines and Systems》 CSCD 2023年第3期275-283,共9页
Permanent magnet claw pole machine(PMCPM) is a special kind of transverse flux permanent magnet machine. Compared with other electrical machines, it has the advantages of high torque density and high efficiency for hi... Permanent magnet claw pole machine(PMCPM) is a special kind of transverse flux permanent magnet machine. Compared with other electrical machines, it has the advantages of high torque density and high efficiency for high speed operation. However, because of its complex irregular structure, the manufacturing process using silicon sheets is complicated. Soft magnetic composite material(SMC) is manufactured by powder metallurgy technology, which can produce various shapes of stator core structures, so it is easier to produce various irregular shapes of the stator core. However, the raw SMC material is relatively expensive, and the mechanical strength of SMC is weak. In this paper, a PMCPM with hybrid cores is proposed. With the adoption of hybrid silicon sheet-SMC cores and amorphous alloy-SMC cores, the torque ability of PMCPM can be improved greatly and it can have higher efficiency for more wide operation frequency. Meanwhile, its mechanical strength has been improved and it can be designed for high torque direct drive applications as it is a modular machine. Furthermore, three methods are proposed to reduce the additional eddy current loss which resulted from the employment of hybrid cores in PMCPM. 展开更多
关键词 Permanent magnet claw pole machine(PMCPM) Soft magnetic materials(SMC) Hybrid cores Eddy current loss
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Effect of sintering temperature on the physical properties and electrical contact properties of doped AgSnO_2 contact materials 被引量:4
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作者 Hai-tao Wang Zi-xiang Wang +2 位作者 Lian-zheng Wang Jing-qin Wang Yan-cai Zhu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2018年第11期1275-1285,共11页
AgSnO_ 2 electrical contact materials doped with Bi_2O_3,La_2O_3,and TiO_2 were successfully fabricated by the powder metallurgy method under different initial sintering temperatures.The electrical conductivity,densit... AgSnO_ 2 electrical contact materials doped with Bi_2O_3,La_2O_3,and TiO_2 were successfully fabricated by the powder metallurgy method under different initial sintering temperatures.The electrical conductivity,density,hardness,and contact resistance of the Ag Sn O_2/Bi_2O_3,AgSnO_2/La_2O_3,and AgSnO_2/Ti O_2 contact materials were measured and analyzed.The arc-eroded surface morphologies of the doped AgSnO_2 contact materials were investigated by scanning electron microscopy(SEM).The effects of the initial sintering temperature on the physical properties and electrical contact properties of the doped AgSnO_2 contact materials were discussed.The results indicate that the physical properties can be improved and the contact resistance of the AgSnO_2 contact materials can be substantially reduced when the materials are sintered under their optimal initial sintering temperatures. 展开更多
关键词 SINTERING TEMPERATURE CONTACT materials PHYSICAL PROPERTIES electrical CONTACT PROPERTIES
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Effects of electric field on vibrational resonances in Hindmarsh-Rose neuronal systems for signal detection
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作者 李晓霞 薛小鹏 +3 位作者 刘栋杰 余天意 何倩倩 徐桂芝 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第4期730-741,共12页
Changes in the concentration of charged ions in neurons can generate induced electric fields,which can further modulate cell membrane potential.In this paper,Fourier coefficients are used to investigate the effect of ... Changes in the concentration of charged ions in neurons can generate induced electric fields,which can further modulate cell membrane potential.In this paper,Fourier coefficients are used to investigate the effect of electric field on vibrational resonance for signal detection in a single neuron model and a bidirectionally coupled neuron model,respectively.The study found that the internal electric field weakens vibrational resonance by changing two factors,membrane potential and phase-locked mode,while the periodic external electric field of an appropriate frequency significantly enhances the vibrational resonance,suggesting that the external electric field may play a constructive role in the detection of weak signals in the brain and neuronal systems.Furthermore,when the coupling of two neurons is considered,the effect of the electric field on the vibrational resonance is similar to that of a single neuron.The paper also illustrates the effect of electric field coupling on vibrational resonance.This study may provide a new theoretical basis for understanding information encoding and transmission in neurons. 展开更多
关键词 electric field Fourier-coefficient neuronal dynamics vibrational resonance
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The degradation of perovskite precursor
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作者 Mengjia Li Lixiu Zhang +2 位作者 Cong Chen Jiangzhao Chen Liming Ding 《Journal of Semiconductors》 EI CAS CSCD 2023年第1期3-6,共4页
Perovskite solar cells(PSCs)are taking a leading position in thin-film optoelectronic devices due to their excellent optical,physical and electrical properties[1-4].Nevertheless,the stability issue of metal halide per... Perovskite solar cells(PSCs)are taking a leading position in thin-film optoelectronic devices due to their excellent optical,physical and electrical properties[1-4].Nevertheless,the stability issue of metal halide perovskite precursor solution severely retards the future industrialization of PSCs[5-7].In stoichiometry,slight solution composition change will induce severe degradation of device performance. 展开更多
关键词 PEROVSKITE HALIDE FILM
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Torque Ripple Reduction of Synchronous Reluctance Machine by Using Asymmetrical Barriers and Hybrid Magnetic Core 被引量:3
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作者 Chengcheng Liu Kelin Wang +2 位作者 Shaopeng Wang Youhua Wang Jianguo Zhu 《CES Transactions on Electrical Machines and Systems》 CSCD 2021年第1期13-20,共8页
As there is no need of permanent magnet(PM)material and only silicon steel sheet required on the rotor,synchronous reluctance machine(SynRM)can be used for many applications and draws a great research interest.For the... As there is no need of permanent magnet(PM)material and only silicon steel sheet required on the rotor,synchronous reluctance machine(SynRM)can be used for many applications and draws a great research interest.For the SynRM,the torque ripple is a big issue and a great of work could been done on reducing it.In this paper,asymmetrical magnetic flux barriers in the SynRM rotor were studied comprehensively,including angle and width of each layer and each side of the magnetic barrier.The SynRMb with asymmetrical and parallel magnetic flux barrier was found as the best way to design SynRM based on the multi-objective design optimization method.Moreover,each parameter was studied to show the design rule of the asymmetrical magnetic flux barrier.As the average torque will be reduced with the asymmetrical barrier is used,the grain-oriented silicon steel is used on stator teeth of the SynRMb(SynRMbG)was proposed and studied.The analysis results show that the proposed new method can make the SynRM have better performance. 展开更多
关键词 Torque ripple reduction synchronous reluctance machine asymmetrical barriers hybrid magnetic core
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Equation of state for aluminum in warm dense matter regime
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作者 王坤 张董 +3 位作者 史宗谦 石元杰 王天浩 张阅 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第1期511-517,共7页
A semi-empirical equation of state model for aluminum in a warm dense matter regime is constructed. The equation of state, which is subdivided into a cold term, thermal contributions of ions and electrons, covers a br... A semi-empirical equation of state model for aluminum in a warm dense matter regime is constructed. The equation of state, which is subdivided into a cold term, thermal contributions of ions and electrons, covers a broad range of phase diagram from solid state to plasma state. The cold term and thermal contribution of ions are from the Bushman–Lomonosov model, in which several undetermined parameters are fitted based on equation of state theories and specific experimental data. The Thomas–Fermi–Kirzhnits model is employed to estimate the thermal contribution of electrons. Some practical modifications are introduced to the Thomas–Fermi–Kirzhnits model to improve the prediction of the equation of state model. Theoretical calculation of thermodynamic parameters, including phase diagram, curves of isothermal compression at ambient temperature, melting, and Hugoniot, are analyzed and compared with relevant experimental data and other theoretical evaluations. 展开更多
关键词 equation of state phase DIAGRAM WARM DENSE MATTER
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Tuning the bandgap of double perovskites
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作者 Yu Zou Wenjin Yu +3 位作者 Lixiu Zhang Cuncun Wu Lixin Xiao Liming Ding 《Journal of Semiconductors》 EI CAS CSCD 2021年第12期6-8,共3页
With great achievements in efficiency,stability,and large-scale preparation of perovskite solar cells(PSCs),the com-mercialization of PSC is ongoing,but there is still an issue on lead toxicity.Although lead content i... With great achievements in efficiency,stability,and large-scale preparation of perovskite solar cells(PSCs),the com-mercialization of PSC is ongoing,but there is still an issue on lead toxicity.Although lead content in the device is low,the water solubility of lead salts leads to potential environmental pollution.At present,the non-lead perovskites studied in-clude:divalent metal perovskite(e.g.,Sn^(2+),Ge^(2+),Cu^(2+)),trivalent metal perovskite(e.g.,Bi^(3+),Sb^(3+),In^(3+)),tetravalent met-al double perovskite(e.g.,Sn^(4+),Pd^(4+),Ti^(4+),Pt^(4+))and mono-trivalent mixed double perovskite(e.g.,Ag+and Bi^(3+),Ag+and In^(3+),Ag^(+)and Sb^(3+)).Their properties are summarized in Table 1.Since the first report on non-lead double perovskite Cs2AgBiBr6 in 2016^([1]). 展开更多
关键词 PEROVSKITE DOUBLE valent
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Electromagnetic Performance Analysis of Flux-Switching Permanent Magnet Tubular Machine with Hybrid Cores 被引量:1
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作者 Shaopeng Wang Chengcheng Liu +3 位作者 Youhua Wang Gang Lei Youguang Guo Jianguo Zhu 《CES Transactions on Electrical Machines and Systems》 CSCD 2020年第1期43-52,共10页
The performance of traditional flux switching permanent magnet tubular machine(FSPMTM)are improved by using new material and structure in this paper.The existing silicon steel sheet making for all mover cores or part ... The performance of traditional flux switching permanent magnet tubular machine(FSPMTM)are improved by using new material and structure in this paper.The existing silicon steel sheet making for all mover cores or part of stator cores are replaced by soft magnetic composite(SMC)cores,and the lamination direction of the silicon steel sheet in stator cores have be changed.The eddy current loss of the machine with hybrid cores will be reduced greatly as the magnetic flux will not pass through the silicon steel sheet vertically.In order to reduce the influence of end effect,the unequal stator width design method is proposed.With the new design,the symmetry of the permanent magnet flux linkage has been improved greatly and the cogging force caused by the end effect has been reduced.Both 2-D and 3-D finite element methods(FEM)are applied for the quantitative analysis. 展开更多
关键词 Flux switching permanent magnet tubular machine soft magnetic composite(SMC) hybrid cores unequal width stator finite element method(FEM).
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Development of a New Flux Switching Transverse Flux Machine with the Ability of Linear Motion 被引量:1
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作者 Chengcheng Liu Shaopeng Wang +3 位作者 Youhua Wang Gang Lei Youguang Guo Jianguo Zhu 《CES Transactions on Electrical Machines and Systems》 2018年第4期384-391,共8页
This paper proposes a new rotary flux switching transverse flux machine with the ability of linear motion(FSTFMaLM),in which both the stator and the rotor cores are made by using soft magnetic composite(SMC)materials.... This paper proposes a new rotary flux switching transverse flux machine with the ability of linear motion(FSTFMaLM),in which both the stator and the rotor cores are made by using soft magnetic composite(SMC)materials.With the special design pattern,for the rotary motion model,the proposed machine can combine both the advantages of the flux switching permanent magnet machine(FSPMM)and the transverse flux machine(TFM).It can output with relatively high torque density,and as there is no windings or the magnets on the rotor cores,the proposed machine can operate in the high speed region to improve the output power.With the adoption of the SMC materials,the manufacturing of this machine can be quite easy.By stacking the rotor core together and prolong it with the determined length in the axial direction,in addition with the special control algorithm,the proposed machine can have the ability of the linear motion.In this paper,the operation principle of this machine has been explained and the design methods are also presented.To seek the better performance,the main dimension of the machine is optimized,and for the performance evaluation,the finite element method(FEM)is adopted.The proposed machine can be used for the electric driving systems,robotic systems or other applications where the linear motion ability is required. 展开更多
关键词 Flux switching linear motion high torque density soft magnetic composite(SMC) transverse flux machine
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Oscillation of S5 helix under different temperatures in determination of the open probability of TRPV1 channel
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作者 李铁 李军委 +3 位作者 庞春丽 安海龙 耿轶钊 王景芹 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第9期574-580,共7页
Transient receptor potential vanilloid subtype 1 (TRPV1) is a polymodel sensory receptor and can be activated by moderate temperature (≥ 43 ℃). Though extensive researches on the heat-activation mechanism revealed s... Transient receptor potential vanilloid subtype 1 (TRPV1) is a polymodel sensory receptor and can be activated by moderate temperature (≥ 43 ℃). Though extensive researches on the heat-activation mechanism revealed some key elements that participate in the heat-sensation pathway, the detailed thermal-gating mechanism of TRPV1 is still unclear. We investigate the heat-activation process of TRPV1 channel using the molecular dynamics simulation method at different temperatures. It is found that the favored state of the supposed upper gate of TRPV1 cannot form constriction to ion permeation. Oscillation of S5 helix originated from thermal fluctuation and forming/breaking of two key hydrogen bonds can transmit to S6 helix through the hydrophobic contact between S5 and S6 helix. We propose that this is the pathway from heat sensor of TRPV1 to the opening of the lower gate. The heat-activation mechanism of TRPV1 presented in this work can help further functional study of TRPV1 channel. 展开更多
关键词 TRPV1 heat-activation mechanism molecular dynamics simulation hydrogen bond GATING
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Effect of astrocyte on synchronization of thermosensitive neuron–astrocyte minimum system
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作者 单仪萱 杨惠兰 +3 位作者 王宏斌 张帅 李颖 徐桂芝 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第8期325-336,共12页
Astrocytes have a regulatory function on the central nervous system(CNS), especially in the temperature-sensitive hippocampal region. In order to explore the thermosensitive dynamic mechanism of astrocytes in the CNS,... Astrocytes have a regulatory function on the central nervous system(CNS), especially in the temperature-sensitive hippocampal region. In order to explore the thermosensitive dynamic mechanism of astrocytes in the CNS, we establish a neuron-astrocyte minimum system to analyze the synchronization change characteristics based on the Hodgkin-Huxley model, in which a pyramidal cell and an interneuron are connected by an astrocyte. The temperature range is set as 0-40 ℃ to juggle between theoretical calculation and the reality of a brain environment. It is shown that the synchronization of thermosensitive neurons exhibits nonlinear behavior with changes in astrocyte parameters. At a temperature range of0 ℃-18 ℃, the effects of the astrocyte can provide a tremendous influence on neurons in synchronization. We find the existence of a value for inositol triphosphate(IP_(3)) production rate and feedback intensities of astrocytes to neurons, which can ensure the weak synchronization of two neurons. In addition, it is revealed that the regulation of astrocytes to pyramidal cells is more sensitive than that to interneurons. Finally, it is shown that the synchronization and phase transition of neurons depend on the change in Ca^(2+) concentration at the temperature of weak synchronization. The results in this paper provide some enlightenment on the mechanism of cognitive dysfunction and neurological disorders with astrocytes. 展开更多
关键词 astrocytes SYNCHRONIZATION Hodgkin–Huxley model thermosensitive neuron
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Study on Vector Magnetic Properties of Magnetic Materials Using Hybrid Hysteresis Model
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作者 Dandan Li Zhenyang Qiao +2 位作者 Na Yang Yinmao Song Yongjian Li 《CES Transactions on Electrical Machines and Systems》 CSCD 2019年第3期292-296,共5页
This paper presents a method to study the vector magnetic properties of magnetic materials under alternating and rotational magnetic field using 2-D vector hybrid hysteresis model.Combining Preisach model and Stoner-W... This paper presents a method to study the vector magnetic properties of magnetic materials under alternating and rotational magnetic field using 2-D vector hybrid hysteresis model.Combining Preisach model and Stoner-Wohlfarth(S-W)model,the vector hybrid hysteresis model is established for magnetic materials.The alternating and rotational hysteresis properties are calculated under different excitation frequency,respectively.And the computed results are compared with the experimental measurement ones.It is shown that the vector model can simulate the alternating and rotational magnetic properties effectively under low magnetization fields and low excitation frequency. 展开更多
关键词 Hybrid hysteresis model magnetic materials vector magnetic properties.
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A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics
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作者 Qian Wang Yanyan Li +7 位作者 Yong Lin Yuping Sun Chong Bai Haorun Guo Ting Fang Gaohua Hu Yanqing Lu Desheng Kong 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第5期120-133,共14页
Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composite... Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured skin.Hybrid electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device interfaces.However,chemical modifications are typically needed for reliable bonding,which can alter their original properties.To overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid electrodes.In this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the hydrogel.The microfoam-enabled bonding strategy is generally compatible with various polymers.The resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked hybrids.These electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive hydrogels.They have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle contractions.Interlocked nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems. 展开更多
关键词 Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites HYDROGEL
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Study on surface discharge of nonlinear conductive epoxy resin/SrTiO3 composites in 80–300 K temperature zone
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作者 Yunqi Xing Bin Wang +3 位作者 Mingyang Wang Jiakai Chi Peng Jia Rongjin Huang 《High Voltage》 SCIE EI CSCD 2024年第1期117-126,共10页
Bisphenol F epoxy resin(EP)is often used in terminal current lead insulation of superconducting equipment because of its good insulation performance,high mechanical strength,good toughness at cryogenic temperatures,an... Bisphenol F epoxy resin(EP)is often used in terminal current lead insulation of superconducting equipment because of its good insulation performance,high mechanical strength,good toughness at cryogenic temperatures,and resistance to cold shock and heat shock.However,due to the wide temperature range of 80–300 K and the strong electric field,the EP-N_(2)interface is prone to surface flashover,resulting in terminal insulation failure.To improve the reliability of the current lead insulation,non-linear conductive EP/strontium titanate(SrTiO_(3))composites were prepared by modification with nano filling.The changes of dielectric,surface discharge,flashover,and trap distribution characteristics of composite materials were studied,and the mechanism of SrTiO_(3)on the surface flashover of composite materials was analysed.The results show that the conductivity of the composite increases with the rise of SrTiO_(3)filling content,and the amplitude of improvement is greater under the strong electric field,showing a more significant non-linearity.The composite has a lower trap energy level and a greater number of shallow traps compared to pure EP,which accelerates surface charge detrapping and reduces charge accumulation,effectively enhancing the discharge and surface flashover voltage of the composite. 展开更多
关键词 COMPOSITES COMPOSITE INSULATION
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Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS 被引量:1
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作者 Jinping Wang Chang Qu +6 位作者 Xinyue Shao Guoqiang Song Jingyu Sun Donghong Shi Ran Jia Hailong An Hongjun Wang 《Bioactive Materials》 SCIE CSCD 2023年第2期404-417,共14页
Human cancers typically express a high level of tumor-promoting mutant p53 protein(Mutp53)with a minimal level of tumor-suppressing wild-type p53 protein(WTp53).In this regard,inducing Mutp53 degradation while activat... Human cancers typically express a high level of tumor-promoting mutant p53 protein(Mutp53)with a minimal level of tumor-suppressing wild-type p53 protein(WTp53).In this regard,inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor therapy.Herein,a new carrier-free nanoprodrug(i.e.,Mn-ZnO_(2)nanoparticles)was developed for concurrent delivery of dual Zn-Mn ions and reactive oxygen species(ROS)within tumor to regulate the p53 protein for high anti-tumor efficacy.In response to the mild tumor acidic environment,the released Zn^(2+)and H_(2)O_(2)from Mn-ZnO_(2)NPs induced ubiquitination-mediated proteasomal degradation of Mutp53,while the liberative Mn^(2+)and increased ROS level activated the ATM-p53-Bax pathway to elevate WTp53 level.Both in vitro and in vivo results demonstrated that pH-responsive decomposition of Mn-ZnO2 NPs could effectively elevate the intracellular dual Zn-Mn ions and ROS level and subsequently generate the cytotoxic hydroxyl radical(·OH)through the Fenton-like reaction.With the integration of multiple functions(i.e.,carrier-free ion and ROS delivery,tumor accumulation,p53 protein modulation,toxic·OH generation,and pH-activated MRI contrast)in a single nanosystem,Mn-ZnO_(2)NPs demonstrate its superiority as a promising nanotherapeutics for p53-mutated tumor therapy. 展开更多
关键词 p53-mutated tumor therapy Wild-type p53 protein Carrier-free nanoprodrug Mn-ZnO_(2)nanoparticle Reactive oxygen species
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Cooperative effect of Cr and Al elements on passivation enhancement of eutectic high-entropy alloy AlCoCrFeNi_(2.1)with precipitates
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作者 Xiaotian Duan Tiezhuang Han +5 位作者 Xiao Guan Yuning Wang Huhu Su Kaisheng Ming Jing Wang Shijian Zheng 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第5期97-108,共12页
In conventional corrosion-resistant alloys,precipitation usually reduces corrosion resistance severely by weakening passive films locally.In this work,we found that the aging-treated AlCoCrFeNi_(2.1)sam-ples,which hav... In conventional corrosion-resistant alloys,precipitation usually reduces corrosion resistance severely by weakening passive films locally.In this work,we found that the aging-treated AlCoCrFeNi_(2.1)sam-ples,which have abundant nanosized L 12 and body-centered cubic(BCC)precipitates in the lamellar face-centered cubic(FCC)and B2 phases,displayed better corrosion resistance than solution-treated AlCoCrFeNi_(2.1)samples without precipitates.In the AlCoCrFeNi_(2.1)alloy,the FCC phase with L1_(2)precipi-tates and the B2 phase with BCC precipitates were protected by passive films enriched with Cr and Al elements,respectively.Moreover,the Al-rich passive film of the B2 phase was less stable than the Cr-rich passive film of the FCC phase,so B2 phase dissolved preferentially.The Cr-rich passive film of the FCC phase remained stable with the formation of Al-rich L1_(2)precipitates inside the phase because those precipitates with the size of∼5 nm were too small to affect the composition of the Cr-rich passive film.The formation of Cr-rich BCC precipitates within the B2 phase increased the content of the Al element inside the phase,improving the stability of Al-rich passive film on the B2 phase.Furthermore,BCC precip-itates with the size of∼30 nm were protected by Cr-rich passive film,which could inhibit the expansion of corrosion pits.Thus,the corrosion resistance of eutectic high-entropy alloy AlCoCrFeN 2.1 was unprece-dentedly enhanced by the precipitation of BCC precipitates.Our study could provide an attractive strategy for designing high-entropy alloys with excellent corrosion resistance and high strength. 展开更多
关键词 Eutectic high-entropy alloy Passive film Corrosion resistance PRECIPITATES TEM
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Measured Impedance and Threshold Value of Electrode Line Impedance Supervision Based Protection in HVDC Transmission System
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作者 Qiang Sun Bin Li +1 位作者 Jiawei He Ye Li 《Journal of Modern Power Systems and Clean Energy》 SCIE EI CSCD 2023年第4期1294-1304,共11页
At present,electrode line impedance supervision(ELIS)based protection is widely used to detect faults on grounding electrode lines,which are indispensable elements of high-voltage direct current(HVDC)systems.The exist... At present,electrode line impedance supervision(ELIS)based protection is widely used to detect faults on grounding electrode lines,which are indispensable elements of high-voltage direct current(HVDC)systems.The existing theoretical analysis of measured impedance is based on lumped line model and the threshold value is generally set according to engineering experience,which have caused the dead zone problem and even accidents.Therefore,a study on measured impedance of ELIS-based protection and its threshold value selection method is carried out to solve this problem.In this study,the expressions of measured impedance under normal operation and fault conditions are deduced based on rigorous and accurate line model.Based on the expressions,the characteristics of the measured impedance are calculated and analyzed.With the characteristics of the measured impedance,the applicability of the protection with the traditional threshold value is further discussed and the distribution of the dead zone can be located.Then,the method to calculate the threshold value of ELIS-based protection is proposed.With a proper threshold value selected by the proposed method,the dead zone of ELIS-based protection is effectively eliminated,and the protection can identify all types of faults even with large transition resistances.Case studies on PSCAD/EMTDC have been conducted to verify the conclusion. 展开更多
关键词 Grounding electrode line electrode line impedance supervision(ELIS)based protection measured impedance characteristic threshold value selection
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