A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major ...A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides (AMPs) and the formation of the mucus layer. We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease. Barrier disturbances including a defective production of AMPs, alterations in thickness or composition of the intestinal mucus layer, alterations of pattern-recognition receptors, defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis.展开更多
The distribution of stress and strain fields in a micro-structuralarea of a particle reinforced composite is studied by a combinationof experimental and numerical method (hybrid method). With the ex-perimental values ...The distribution of stress and strain fields in a micro-structuralarea of a particle reinforced composite is studied by a combinationof experimental and numerical method (hybrid method). With the ex-perimental values of displacements in a micro-region as the boundaryloading condition, strain and stress fields inside the micro-regionare calculated by the finite element method under tow different kindsof model- ing, namely, as pale stress and plane strain condition. Thedifferences between the two kinds of modeling conditions as appliedto micro-structural areas are discussed.展开更多
A series of problems in mechanics and physics are governed by the ordinary Poisson equation which demands linearity,isotropy,and material homo- geneity.In this paper a generalization with respect to nonlinearity,aniso...A series of problems in mechanics and physics are governed by the ordinary Poisson equation which demands linearity,isotropy,and material homo- geneity.In this paper a generalization with respect to nonlinearity,anisotropy,and inhomogeneity is made.Starting from the canonical basic equations in the primal and dual formulation respectively we derive systematically the corresponding generalized variational principles;under certain conditions they can be extended to so called complementary extremum principles allowing for global bounds.For simplicity a restriction to two dimensional problems is made,including twice-connected domains.展开更多
The effect of C,Mn and heat-treatment on work-hardening of austenitic Mn steel and the work-hardening mechanism have been investigated under non-severe impact loading condition.The results show that the ability of wor...The effect of C,Mn and heat-treatment on work-hardening of austenitic Mn steel and the work-hardening mechanism have been investigated under non-severe impact loading condition.The results show that the ability of work-hardening in- creases with the increase of C and aging tempera- ture but decreases with Mn.The work-hardening with high austenitic stability results mainly from dislocations,and that with low austenitic stability results mainly from combined effects of strain-in- duced martensite and high density of dislocations under non-severe impact loading conditions.The wear resistance of medium manganese steel (Mn7) is 1.64-2.46 times that of Hadfield steel (Mnl3).展开更多
The research aims at differentiating dominant crop cultures in two test sites of Baden-Wuert- temberg, Southern Germany by creating crop signatures from radar backscatter values. It seeks to establish whether the crop...The research aims at differentiating dominant crop cultures in two test sites of Baden-Wuert- temberg, Southern Germany by creating crop signatures from radar backscatter values. It seeks to establish whether the crop signatures collected in one test site are comparable or transferable to another test site. The two test sites are located in different agro-ecological zones as described in the climate maps of the “Klimaatlas Baden-Wuerttemberg”. TerraSAR-X images (VV polarization) for the months of July and August 2010 were overlaid with crop fields’ ground truth data. As pre-processing steps, radiometric correction was carried out on the images in order to normalize the topographical effects. Classification of the crops was performed on a field scale, according to the mean and standard deviation of their backscatter values. From the results, potatoes could be uniquely differentiated from the cereals in the two different test sites for both the months of July and August 2010. Cereals (rapes, maize, barley, wheat and oats) had comparable backscatter values and their differentiation varied from one test site to another. The results’ accuracy obtained with a maximum kappa coefficient of 0.82 agrees with results of a similar research carried out in North East Germany.展开更多
As a part of an effort to roll back malaria in Nigeria, exploring the use of geographically related tools triggered the use of modern approaches of knowing the spatial distribution of target populations to attain sign...As a part of an effort to roll back malaria in Nigeria, exploring the use of geographically related tools triggered the use of modern approaches of knowing the spatial distribution of target populations to attain significant malaria elimination intervention. GIS tool was used for geographical reconnaissance (GR), providing demographic data on respondents’ household and spatial information on the distribution of households in the selected location. A cross-sectional study design was used to collect spatial data in the two locations, while a quantitative questionnaire was used to collect the household data. The analysis of field data indicated that 49,500 unique households were enumerated and thus included in the Indoor Residual Spraying to prevent malaria infection, covering 424 towns in the two Local Government Areas (LGAs). 383,301 persons were recorded during the GR exercise in Doma and Nassarawa Eggon LGAs out of which 79,339 were children of agesless than five years, with 13,526 pregnant women. Further data analysis revealed that the average number of persons per household in both LGAs was approximately eight. The spatial information from the GR provides a foundation for an updateable database for any future survey for developmental activities in Nigeria. The use of modern GR approach has proved to be accurate, reliable and more cost effective and less cumbersome than the traditional approach in the collection and geo-positioning of household data. Use of Garmin e-Trex GPS handheld instruments to collect household data in the designated areas removed the constraints of expensive Personal Digital Assistants and reduced errors of wrong location coordinates. Several African countries which did not use GR or applied the use of Geospatial tool appropriately had setbacks. The previous study in other countries showed limitations which was characterized by substantial inherent logistical and technical challenges culminating in missed targets. This setback was addressed in our study.展开更多
The two topics of the article seem to have absolutely nothing to do with each other and,as can be expected in a contribution in honor and memory of Prof.Fritz Ackermann,they are linked in his person.Vision-based Navig...The two topics of the article seem to have absolutely nothing to do with each other and,as can be expected in a contribution in honor and memory of Prof.Fritz Ackermann,they are linked in his person.Vision-based Navigation was the focus of the doctoral thesis written by the author,the 29th and last PhD thesis supervised by Prof.Ackermann.The International Master’s Program Photogrammetry and Geoinformatics,which the author established with colleagues at Stuttgart University of Applied Sciences(HfT Stuttgart)in 1999,was a consequence of Prof.Ackermann’s benevolent promotion of international knowledge transfer in teaching.Both topics are reflected in this article;they provide further splashes of color in Prof.Ackermann’s oeuvre.展开更多
This paper presents the results of a combined study of building energy consumption and the electricity production from PV modules integrated into a shading device, taking account of different site layouts. Various com...This paper presents the results of a combined study of building energy consumption and the electricity production from PV modules integrated into a shading device, taking account of different site layouts. Various combinations of surrounding building configurations and the tilt angles of the shading device （that determines the PV module orientation） are examined.展开更多
Global plastics production is expected to exceed 400 million tons and reach 600 million tons by 2060.Their synthesis currently accounts for approximately 3%of global greenhouse gas emissions.Approximately 60%of all po...Global plastics production is expected to exceed 400 million tons and reach 600 million tons by 2060.Their synthesis currently accounts for approximately 3%of global greenhouse gas emissions.Approximately 60%of all polymers are produced for single-use.Examples include shopping bags,packaging materials,mulch films,and soluble polymers for cosmetics and other purposes.Currently,only a portion of single-use plastic is recycled or disposed of in incinerators or landfills.An estimated 20%is not disposed of properly and pollutes the global environment,especially the oceans.In response to these challenges,the United Nations,European Union,and many nation-states are developing regulatory frameworks that encourage the chemical industry to produce plastics with a smaller environmental footprint and often support this through research funding.Possible solutions include:(1)the use of green energy,green hydrogen,bio-based feedstocks,or CO_(2) in synthesis;(2)the reuse or recycling of plastics through conversion or pyrolysis;and(3)the production of biodegradable polymers.The German chemical industry contributes approximately one-third of polymer production in the EU.It is embedded in the EU regulatory and research landscape and anchored in the European Green Deal,which aims for carbon neutrality by 2050.In this paper,we describe how BASF and Evonik,two leading German chemical companies with strong but different polymer portfolios,respond to the call for greener polymers and how technologies are being developed to make polyurethanes,a particularly important and difficult-to-recycle family of elastomers and duromers,renewable and circular.Reducing the environmental footprint of plastics requires not only innovative materials but also proper governance,regulatory and collection systems,and public willingness to cooperate.In an international comparison of these competencies,expressed by the"polymer management index"(PMI),Germany achieved a top position.展开更多
With the rapid development of reality capture methods,such as laser scanning and oblique photogrammetry,point cloud data have become the third most important data source,after vector maps and imagery.Point cloud data ...With the rapid development of reality capture methods,such as laser scanning and oblique photogrammetry,point cloud data have become the third most important data source,after vector maps and imagery.Point cloud data also play an increasingly important role in scientific research and engineering in the fields of Earth science,spatial cognition,and smart cities.However,how to acquire high-quality three-dimensional(3D)geospatial information from point clouds has become a scientific frontier,for which there is an urgent demand in the fields of surveying and mapping,as well as geoscience applications.To address the challenges mentioned above,point cloud intelligence came into being.This paper summarizes the state-of-the-art of point cloud intelligence,with regard to acquisition equipment,intelligent processing,scientific research,and engineering applications.For this purpose,we refer to a recent project on the hybrid georeferencing of images and LiDAR data for high-quality point cloud collection,as well as a current benchmark for the semantic segmentation of high-resolution 3D point clouds.These projects were conducted at the Institute for Photogrammetry,the University of Stuttgart,which was initially headed by the late Prof.Ackermann.Finally,the development prospects of point cloud intelligence are summarized.展开更多
Scatterometry is a well-established,fast and precise optical metrology method used for the characterization of sub-lambda periodic features.The Fourier scatterometry method,by analyzing the Fourier plane,makes it poss...Scatterometry is a well-established,fast and precise optical metrology method used for the characterization of sub-lambda periodic features.The Fourier scatterometry method,by analyzing the Fourier plane,makes it possible to collect the angle-resolved diffraction spectrum without any mechanical scanning.To improve the depth sensitivity of this method,we combine it with white light interferometry.We show the exemplary application of the method on a silicon line grating.To characterize the sub-lambda features of the grating structures,we apply a model-based reconstruction approach by comparing simulated and measured spectra.All simulations are based on the rigorous coupled-wave analysis method.展开更多
K-ion battery (KIB) is a new-type energy storage device that possesses potential advantages of low-cost and abundant resource of potassium.To develop advanced electrode materials for accommodating the large size and h...K-ion battery (KIB) is a new-type energy storage device that possesses potential advantages of low-cost and abundant resource of potassium.To develop advanced electrode materials for accommodating the large size and high activity of potassium ion is of great interests.Herein,a segment-like antimony (Sb) nanorod encapsulated in hollow carbon tube electrode material (Sb@HCT) was prepared.Beneficial from the virtue of abundant nitrogen doping in carbon tube,one-dimensional and hollow structure advantages,Sb@HCT exhibits excellent potassium storage properties:in the case of potassium bis(fluorosulfonyl)imide (KFSI) electrolyte,Sb@HCT displays a reversible capacity of up to 453.4 mAh·g^-1 at a current density of 0.5 A·g^-1 and good rate performance (a capacity of 211.5 mAh·g^-1 could be achieved at an ultrahigh rate of 5 A·g^-1).Additionally,Sb@HCT demonstrates excellent long-cycle stability at a current density of 2 A·g^-1 over 120 cycles.Meanwhile,electrolyte optimization is an effective strategy for greatly improving electrochemical performance.Through ex-situ characterizations,we disclosed the potassiation of Sb anode is quite reversible and undergoes multistep processes,combining solid solution reaction and two-phase reaction.展开更多
基金Supported by Robert Bosch Foundation,Stuttgart,Germany
文摘A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides (AMPs) and the formation of the mucus layer. We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease. Barrier disturbances including a defective production of AMPs, alterations in thickness or composition of the intestinal mucus layer, alterations of pattern-recognition receptors, defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis.
基金the National Natural Science Foundation of China(19972046)National Overseas Study Foundation
文摘The distribution of stress and strain fields in a micro-structuralarea of a particle reinforced composite is studied by a combinationof experimental and numerical method (hybrid method). With the ex-perimental values of displacements in a micro-region as the boundaryloading condition, strain and stress fields inside the micro-regionare calculated by the finite element method under tow different kindsof model- ing, namely, as pale stress and plane strain condition. Thedifferences between the two kinds of modeling conditions as appliedto micro-structural areas are discussed.
文摘A series of problems in mechanics and physics are governed by the ordinary Poisson equation which demands linearity,isotropy,and material homo- geneity.In this paper a generalization with respect to nonlinearity,anisotropy,and inhomogeneity is made.Starting from the canonical basic equations in the primal and dual formulation respectively we derive systematically the corresponding generalized variational principles;under certain conditions they can be extended to so called complementary extremum principles allowing for global bounds.For simplicity a restriction to two dimensional problems is made,including twice-connected domains.
文摘The effect of C,Mn and heat-treatment on work-hardening of austenitic Mn steel and the work-hardening mechanism have been investigated under non-severe impact loading condition.The results show that the ability of work-hardening in- creases with the increase of C and aging tempera- ture but decreases with Mn.The work-hardening with high austenitic stability results mainly from dislocations,and that with low austenitic stability results mainly from combined effects of strain-in- duced martensite and high density of dislocations under non-severe impact loading conditions.The wear resistance of medium manganese steel (Mn7) is 1.64-2.46 times that of Hadfield steel (Mnl3).
文摘The research aims at differentiating dominant crop cultures in two test sites of Baden-Wuert- temberg, Southern Germany by creating crop signatures from radar backscatter values. It seeks to establish whether the crop signatures collected in one test site are comparable or transferable to another test site. The two test sites are located in different agro-ecological zones as described in the climate maps of the “Klimaatlas Baden-Wuerttemberg”. TerraSAR-X images (VV polarization) for the months of July and August 2010 were overlaid with crop fields’ ground truth data. As pre-processing steps, radiometric correction was carried out on the images in order to normalize the topographical effects. Classification of the crops was performed on a field scale, according to the mean and standard deviation of their backscatter values. From the results, potatoes could be uniquely differentiated from the cereals in the two different test sites for both the months of July and August 2010. Cereals (rapes, maize, barley, wheat and oats) had comparable backscatter values and their differentiation varied from one test site to another. The results’ accuracy obtained with a maximum kappa coefficient of 0.82 agrees with results of a similar research carried out in North East Germany.
文摘As a part of an effort to roll back malaria in Nigeria, exploring the use of geographically related tools triggered the use of modern approaches of knowing the spatial distribution of target populations to attain significant malaria elimination intervention. GIS tool was used for geographical reconnaissance (GR), providing demographic data on respondents’ household and spatial information on the distribution of households in the selected location. A cross-sectional study design was used to collect spatial data in the two locations, while a quantitative questionnaire was used to collect the household data. The analysis of field data indicated that 49,500 unique households were enumerated and thus included in the Indoor Residual Spraying to prevent malaria infection, covering 424 towns in the two Local Government Areas (LGAs). 383,301 persons were recorded during the GR exercise in Doma and Nassarawa Eggon LGAs out of which 79,339 were children of agesless than five years, with 13,526 pregnant women. Further data analysis revealed that the average number of persons per household in both LGAs was approximately eight. The spatial information from the GR provides a foundation for an updateable database for any future survey for developmental activities in Nigeria. The use of modern GR approach has proved to be accurate, reliable and more cost effective and less cumbersome than the traditional approach in the collection and geo-positioning of household data. Use of Garmin e-Trex GPS handheld instruments to collect household data in the designated areas removed the constraints of expensive Personal Digital Assistants and reduced errors of wrong location coordinates. Several African countries which did not use GR or applied the use of Geospatial tool appropriately had setbacks. The previous study in other countries showed limitations which was characterized by substantial inherent logistical and technical challenges culminating in missed targets. This setback was addressed in our study.
文摘The two topics of the article seem to have absolutely nothing to do with each other and,as can be expected in a contribution in honor and memory of Prof.Fritz Ackermann,they are linked in his person.Vision-based Navigation was the focus of the doctoral thesis written by the author,the 29th and last PhD thesis supervised by Prof.Ackermann.The International Master’s Program Photogrammetry and Geoinformatics,which the author established with colleagues at Stuttgart University of Applied Sciences(HfT Stuttgart)in 1999,was a consequence of Prof.Ackermann’s benevolent promotion of international knowledge transfer in teaching.Both topics are reflected in this article;they provide further splashes of color in Prof.Ackermann’s oeuvre.
文摘This paper presents the results of a combined study of building energy consumption and the electricity production from PV modules integrated into a shading device, taking account of different site layouts. Various combinations of surrounding building configurations and the tilt angles of the shading device （that determines the PV module orientation） are examined.
基金the German Federal Ministry of Education and Research(BMBF)for funding part of the work within the Kopernikus Initiative(‘Power-to-X’)under contract number P^(2)X-^(03)SFK2J0.
文摘Global plastics production is expected to exceed 400 million tons and reach 600 million tons by 2060.Their synthesis currently accounts for approximately 3%of global greenhouse gas emissions.Approximately 60%of all polymers are produced for single-use.Examples include shopping bags,packaging materials,mulch films,and soluble polymers for cosmetics and other purposes.Currently,only a portion of single-use plastic is recycled or disposed of in incinerators or landfills.An estimated 20%is not disposed of properly and pollutes the global environment,especially the oceans.In response to these challenges,the United Nations,European Union,and many nation-states are developing regulatory frameworks that encourage the chemical industry to produce plastics with a smaller environmental footprint and often support this through research funding.Possible solutions include:(1)the use of green energy,green hydrogen,bio-based feedstocks,or CO_(2) in synthesis;(2)the reuse or recycling of plastics through conversion or pyrolysis;and(3)the production of biodegradable polymers.The German chemical industry contributes approximately one-third of polymer production in the EU.It is embedded in the EU regulatory and research landscape and anchored in the European Green Deal,which aims for carbon neutrality by 2050.In this paper,we describe how BASF and Evonik,two leading German chemical companies with strong but different polymer portfolios,respond to the call for greener polymers and how technologies are being developed to make polyurethanes,a particularly important and difficult-to-recycle family of elastomers and duromers,renewable and circular.Reducing the environmental footprint of plastics requires not only innovative materials but also proper governance,regulatory and collection systems,and public willingness to cooperate.In an international comparison of these competencies,expressed by the"polymer management index"(PMI),Germany achieved a top position.
基金supported by the National Natural Science Foundation Project(No.42130105)Key Laboratory of Spatial-temporal Big Data Analysis and Application of Natural Resources in_Megacities,MNR(No.KFKT-2022-01).
文摘With the rapid development of reality capture methods,such as laser scanning and oblique photogrammetry,point cloud data have become the third most important data source,after vector maps and imagery.Point cloud data also play an increasingly important role in scientific research and engineering in the fields of Earth science,spatial cognition,and smart cities.However,how to acquire high-quality three-dimensional(3D)geospatial information from point clouds has become a scientific frontier,for which there is an urgent demand in the fields of surveying and mapping,as well as geoscience applications.To address the challenges mentioned above,point cloud intelligence came into being.This paper summarizes the state-of-the-art of point cloud intelligence,with regard to acquisition equipment,intelligent processing,scientific research,and engineering applications.For this purpose,we refer to a recent project on the hybrid georeferencing of images and LiDAR data for high-quality point cloud collection,as well as a current benchmark for the semantic segmentation of high-resolution 3D point clouds.These projects were conducted at the Institute for Photogrammetry,the University of Stuttgart,which was initially headed by the late Prof.Ackermann.Finally,the development prospects of point cloud intelligence are summarized.
基金We are thankful for the technical support given by Thomas Schoder.This work was supported by the German DFG-funded priority program(SPP1327)on‘Optically generated sub-100 nm structures for technical and bio-medical applications’within the subproject‘Development of a functional sub-100 nm 3D two-photon polymerization technique and optical characterization methods’and the DFG project‘Inverse-source and inverse-diffraction problems in photonics(OS111/32-1).’。
文摘Scatterometry is a well-established,fast and precise optical metrology method used for the characterization of sub-lambda periodic features.The Fourier scatterometry method,by analyzing the Fourier plane,makes it possible to collect the angle-resolved diffraction spectrum without any mechanical scanning.To improve the depth sensitivity of this method,we combine it with white light interferometry.We show the exemplary application of the method on a silicon line grating.To characterize the sub-lambda features of the grating structures,we apply a model-based reconstruction approach by comparing simulated and measured spectra.All simulations are based on the rigorous coupled-wave analysis method.
基金the National Natural Science Foundation of China (No.51832004)the National Natural Science Fund for Distinguished Young Scholars (No.51425204)+2 种基金the National Key R&D Program of China (No.2016YFA0202603)the Programme of Introducing Talents of Discipline to Universities (No.B17034)the Yellow Crane Talent (Science & Technology) Program of Wuhan City.
文摘K-ion battery (KIB) is a new-type energy storage device that possesses potential advantages of low-cost and abundant resource of potassium.To develop advanced electrode materials for accommodating the large size and high activity of potassium ion is of great interests.Herein,a segment-like antimony (Sb) nanorod encapsulated in hollow carbon tube electrode material (Sb@HCT) was prepared.Beneficial from the virtue of abundant nitrogen doping in carbon tube,one-dimensional and hollow structure advantages,Sb@HCT exhibits excellent potassium storage properties:in the case of potassium bis(fluorosulfonyl)imide (KFSI) electrolyte,Sb@HCT displays a reversible capacity of up to 453.4 mAh·g^-1 at a current density of 0.5 A·g^-1 and good rate performance (a capacity of 211.5 mAh·g^-1 could be achieved at an ultrahigh rate of 5 A·g^-1).Additionally,Sb@HCT demonstrates excellent long-cycle stability at a current density of 2 A·g^-1 over 120 cycles.Meanwhile,electrolyte optimization is an effective strategy for greatly improving electrochemical performance.Through ex-situ characterizations,we disclosed the potassiation of Sb anode is quite reversible and undergoes multistep processes,combining solid solution reaction and two-phase reaction.
