Lipoxidation is formed during the oxidation of lipids and specific proteins,causing an alteration in proteins function.Although this occurs under physiological conditions,in many cases,it has been associated with path...Lipoxidation is formed during the oxidation of lipids and specific proteins,causing an alteration in proteins function.Although this occurs under physiological conditions,in many cases,it has been associated with pathological processes,including cancer.Oxidative DNA damage is a significant contributor to cancer development,and lipoxidation products such as malondialdehyde(MDA)and 4-hydroxy-2-nonenal(4-HNE)play a role in the induction of mutations responsible for DNA modifications.Elevations of reactive aldehydes can be seen in patients with metastatic disease in comparison to those without metastatic disease.Lipoxidation adducts can modify the immune response,consequently causing either positive or negative alterations in cancer progression.When reactive aldehydes are added to tumor cells,they exert similar effects to chemotherapeutic drugs by forming DNA adducts and consequently steer the tumor cells toward apoptosis.This article highlights the role of botanical compounds in lipid metabolism,lipid peroxidation,and cell cycle arrest and discusses the potential role they may have in oncology treatments.展开更多
文摘Lipoxidation is formed during the oxidation of lipids and specific proteins,causing an alteration in proteins function.Although this occurs under physiological conditions,in many cases,it has been associated with pathological processes,including cancer.Oxidative DNA damage is a significant contributor to cancer development,and lipoxidation products such as malondialdehyde(MDA)and 4-hydroxy-2-nonenal(4-HNE)play a role in the induction of mutations responsible for DNA modifications.Elevations of reactive aldehydes can be seen in patients with metastatic disease in comparison to those without metastatic disease.Lipoxidation adducts can modify the immune response,consequently causing either positive or negative alterations in cancer progression.When reactive aldehydes are added to tumor cells,they exert similar effects to chemotherapeutic drugs by forming DNA adducts and consequently steer the tumor cells toward apoptosis.This article highlights the role of botanical compounds in lipid metabolism,lipid peroxidation,and cell cycle arrest and discusses the potential role they may have in oncology treatments.
