A detailed quantum mechanical analysis of electronic disposition of five aminopyrimidoisoquinolinequinones (APIQs) was performed after extraction of this subset of compounds from a larger data set of APIQs via a repor...A detailed quantum mechanical analysis of electronic disposition of five aminopyrimidoisoquinolinequinones (APIQs) was performed after extraction of this subset of compounds from a larger data set of APIQs via a reported clustering methodology (Elfaki, et al. 2020). Both semi empirical PM3 method and DFT quantum mechanical methods were used to calculate global and local quantum mechanical descriptors (QMDs) to define the electronic environment of these molecules in attempt to rationalize their observed anti-cancer response variability. The biological response is the anticancer activity against human gastric adenocarcenoma (AGS) cell line. The correlation matrix between the calculated global electronic descriptors and biological activity demonstrated that the global dipole moment gives the highest correlation. The local electronic environment was analysed by The Mullikan charges (MC) and Fukui functions for N-5, C-6, C-8 in addition to the N atom of phenylamino side group at C-8. MCs furnished no useful information as each of these atoms had almost identical MC values for all the five compounds with exception of C-6 which gave varied values. Regressing MCs of C-6 against the response traces 60% of the latter variability. As C-6 is an extra annular methyl carbon adjacent to N-5 in isoquinoline residue of APIQ, we reasoned that the chemical reactivities of 4 out of the 5 APIQs might be due to a Chichibabin-type tautomerism implying a possible alkylation aspect in their mechanism of action. The corresponding Fukui functions (f<sup>-</sup>, f<sup>+</sup> and f<sup>0</sup>) showed a considerable consistency with the patterns of chemical reactivity exhibited by this small set of APIQs.展开更多
Background: Hypocalcaemia is a serious complication that may follows thyroid surgeries. So, the purpose of this study was to determine the frequency of postoperative hypocalcaemia after thyroid surgery in Omdurman mil...Background: Hypocalcaemia is a serious complication that may follows thyroid surgeries. So, the purpose of this study was to determine the frequency of postoperative hypocalcaemia after thyroid surgery in Omdurman military hospital (Jan.-July 2018). Materials & Methods: In this retrospective facility based cross sectional study, 124 files were reviewed, the recorded data were age, sex, residence, diagnosis, type of surgery & postoperative calcium level, data were collected by a designed pretested checklist, data were analyzed by SPSS version 20 by using frequencies & cross tabulations, for postoperative hypocalcaemia. Results: Majority of the patients were between 21 - 41 years 49.2%, majority of them were females 83.9%. 97.6% of them underwent total thyroidectomy, 25% of the patients developed postoperative hypocalcaemia, also we found that there was no relation between sex, type of thyroid surgery & development of postoperative hypocalcaemia (P > 0.001). Conclusion: Our research showed that 25% of the patients who underwent thyroid surgery developed postoperative hypocalcaemia.展开更多
In this paper, which serves as a continuation of earlier work, we generalize the idea of inequalities in metric spaces and use them to demonstrate that the incomplete metric space can be used to obtain a Banach space.
Carissa edulis Vahl is well known in Sudanese herbal medicine,commonly used for treatment of epilepsy,headache,chest pains,rheumatism,skin lesions,mania and other psychoactive diseases.The investigations of the safety...Carissa edulis Vahl is well known in Sudanese herbal medicine,commonly used for treatment of epilepsy,headache,chest pains,rheumatism,skin lesions,mania and other psychoactive diseases.The investigations of the safety use for psychoactive purposes in Sudanese healing traditions and identifying secondary metabolites of the plant extracts are the key steps towards determination of appropriate medicinal doses.Therefore,one of the chemical constituents was isolated and structurally identified by 1H-NMR and LC-MS.With the aim of evaluating Carissa edulis folk random uses,the isolated compound was compared with reference artificial drugs Lormetazepam,a potentially toxic compound.Structure investigations confirm that the isolated product was benzodiazepines analogous 7-chloro 1,4-benzodiazepine-2-ones.It is important to know the potential toxicity of certain plant in order to assess the therapeutic effect of it,as these are slight distinctions between the medicinal and toxic doses.In general the results obtained justify the use of the roots of Carissa edulis in traditional medicine for the treatment of some psychiatric diseases.展开更多
This study was carried out to assess the leaves and fruits of Grewia mollis, Grewia tenax and Grewia villosa for their potentials to produce high nutritive value fodder under semi-arid conditions. The experiment was c...This study was carried out to assess the leaves and fruits of Grewia mollis, Grewia tenax and Grewia villosa for their potentials to produce high nutritive value fodder under semi-arid conditions. The experiment was conducted at the farm of the College of Natural Resources and Environmental Studies, University of Juba-Khartoum-Sudan. Randomized Complete Block design with three replications was used. Proximate analysis was carried to estimate nutritive value, and mineral contents of leaves, seeds and fruit pulp of the three species. Results indicated significant difference （P ≤ 0.05） in nutritive value of the leaves among the three species; dry matter, ash, and acid detergent factor （ADF） kg/ha, while no significant difference was observed among the species in crude protein （CP） and nutrient detergent factor （NDF） kg/ha. Mineral contents of the leaves of the three species showed variations among the species and seasons. Seeds and fruit pulp were found to have considerable levels of nutrients and mineral contents. The nutritive value of the three species was higher in the rainy season compared to the dry season. The results of this study indicate that the three species can be introduced as a source of fodder in animal production farms and silvopastural systems.展开更多
This study was carried out to assess the growth characteristics of Grewia moll＆, Grewia tenax and Grewia villosa under the nursery and field conditions. Two experiments were conducted at the farm of the College of Na...This study was carried out to assess the growth characteristics of Grewia moll＆, Grewia tenax and Grewia villosa under the nursery and field conditions. Two experiments were conducted at the farm of the College of Natural Resources and Environmental Studies, University of Juba, Khartoum, Sudan. Randomized complete block design with three replications was used. Morphological and physiological factors were measured. Seedlings height, number of leaves, number of branches and sub-branches were different （P 〈 0.05） among the three species at the nursery stage and under field conditions. Collar diameter showed significant difference among the species under field conditions. Physiological factors exhibited more significant variations in the field than at the nursery stage. Variations in growth characteristics were attributed to genetics differences and different growth habit, while variations in physiological factors （photosynthesis and transpiration rate） were attributed to differences in leaf structure, size and number of stomatal pores.展开更多
Background: The chemical composition of gallstones is essential to study aetiopathogenesis of gallstone disease. Objective: To determine the composition of gallstones in a Sudanese population. Patients and methods: It...Background: The chemical composition of gallstones is essential to study aetiopathogenesis of gallstone disease. Objective: To determine the composition of gallstones in a Sudanese population. Patients and methods: It describes an extensive quantitative analysis of gallstones from patients presented with symptomatic gall stone disease and treated by cholecystectomy after the acceptance of the pre-given informed consent in Khartoum teaching hospital in the period between Jan 2010 and Dec 2010. Using a pretested questionnaire data collected from and analyzed statistically by SPSS computer program version 21. Results: Data are analyzed from 94 patients (six males and 88 females). Cholesterol stones showed a significantly higher cholesterol content than pigment stones (p = 0.0042), though not significantly higher than mixed stones. Their phospholipids content and inorganic phosphates were higher than in the other types of stones and oxalate content was significantly elevated in comparison with mixed stones (p = 0.0402). In mixed stones, the cholesterol, bile acids, and bilirubin were intermediate between cholesterol and pigment stones, whereas triglycerides were significantly more than pigment stones (p = 0.0007). Bilirubin (p = 0.0021) and bile acids (p = 0.0016) were significantly higher than cholesterol stones (p = 0.0001) and (p = 0.0001) respectively. However, they contained the lowest amounts of sodium, potassium, magnesium, and oxalate. In pigment stones, bilirubin was significantly higher (p = 0.0001) than both groups. Conclusion: Collaborations between surgeons, nutritionists, biochemists, and physicians should be stimulated in future studies to define the different types of gall stones in different areas in Sudan and the relevancy of such types with diets’ traditions.展开更多
A serological survey of Toxoplasma gondii was conducted using LAT （Latex Agglutination Test） on 205 sera collected from working horses and donkeys in Khartoum State, Sudan. The overall sero-prevalence of the investi...A serological survey of Toxoplasma gondii was conducted using LAT （Latex Agglutination Test） on 205 sera collected from working horses and donkeys in Khartoum State, Sudan. The overall sero-prevalence of the investigated equines was 32.7%. Antibodies to T. gondii were found in 38% of 100 horses and 27.6% of 105 donkeys. The titers were 1：2 （4 heads）, 1：4 （11 heads）, 1：8 （13 heads）, 1：16 （17 heads）, 1：32 （5 heads）, 1：64 （10 donkeys） and 1：128 （7 donkeys）. Neither the area nor animal species showed significant differences between the investigated groups. However, age was reported to show significant （P 〈 0.05） effect on equine toxoplasmosis in the Sudan. This is the first report on equine toxoplasmosis in the Sudan.展开更多
Toxoplasmosis is an important cause of reproductive failure in man and farm animals resulting in significant socio-economic losses worldwide. The aim of this study was to avail large scale data-regarding the sero-prev...Toxoplasmosis is an important cause of reproductive failure in man and farm animals resulting in significant socio-economic losses worldwide. The aim of this study was to avail large scale data-regarding the sero-prevalence of T. gondii infection in dairy animals from the Khartoum State, Sudan using the commercially available Latex Agglutination Diagnostic kits. The study revealed that the overall seroprevalence of T. gondii infection at herd level of dairy animals in the State was 92.7%. The within herd seroprevalence was ranging from 8% up to 100% with mean of 51.3% in different herds of different dairy animals species in the State. Only 6 herds, 3 herds, 3 herds and 1 herd of cattle, camel sheep and goat respectively were found to be clean from anti-T, gondii antibody in the present study. Interestingly, most of the clean herds （12 herds） are located in the Khartoum district. The differences between the three districts, the seven localities and the four animal species were statistically highly significant （P 〈 0.01）. The overall sero-prevalence of T. gondii infection in dairy animals--at individual level--was 45.3%. Sheep scored the highest seroprevalence rate （75.0%） followed by goats （64.0%）, camels （54.1%） and cattle （40.9%） with high statistically significant differences （P 〈 0.01）. The highest level of antibody titration was reported in sheep and goats. This is the first area-wide and large scale report on seroprevalence of T. gondii infection in dairy animals from the Sudan. It was concluded that dairy animals in the Sudan are widely exposed to T. gondii and people in the Sudan should be aware of the possibility of hyper-prevalence of human toxoplasmosis through these food animals. Research on clinical toxoplasmosis in dairy animals and human in the Sudan is recommended to evaluate the role T. gondii infection in economical losses in dairy farm industry and for building strategy of sustainable toxoplasmosis control.展开更多
A seroprevalence investigation of human brucellosis was carried out in Kuku Dairy Scheme, Sudan. A total of 176 serum samples were collected and screened by Rose Bengal Plate Test （RBPT）. The positive sera vqere fur...A seroprevalence investigation of human brucellosis was carried out in Kuku Dairy Scheme, Sudan. A total of 176 serum samples were collected and screened by Rose Bengal Plate Test （RBPT）. The positive sera vqere further examined using Tube Agglutination Test （TAT） and c-Elisa. The seropositivity was 15.9%, 14.8% and 11.4% using RBPT, TAT and c-Elisa respectively. Whereas, the active infection based on seropositivity and clinical signs were 4.6%, 4.6% and 2.3% in case of RBPT, TAT and c-Elisa respectively. Based on c-Elisa result the infected individuals were further subjected to clinical examination and treated with streptomycin and doxocycline for six weeks.展开更多
Fruit flies are serious pests of Mango in Sudan; they cause substantial damage to Mango production, both qualitatively and quantitatively. This study is an effort to establish information about the pest and, to test t...Fruit flies are serious pests of Mango in Sudan; they cause substantial damage to Mango production, both qualitatively and quantitatively. This study is an effort to establish information about the pest and, to test the susceptibility of some Mango cultivars （Baladi, Kitchener, Shendi, Alphons, Abu Samaka and Bit abusamaka） to the pest infestation. A survey was carded out at Shendi area, River Nile State, during the period of May 2007 to July 2008, using a home made trap resemble lvnfield traps with attractants （Methyl eugenol, Trimedlure, cue lure and Nu lure） to identify the fruit flies species found in the area and to study the seasonal abundance of the pest species and to determine the infestation percentage of different Mango cultivars. Results indicated that the fruit fly Bactrocera invadens is present all year-round in the study area, with population peak July to September. The study showed that Guava （ Psedium guajava ） represents the best alternative host for the pest. Abu samaka and Bit Abusa amaka mango cultivars were the most susceptible, with 100% infestation, followed by Shendi 70%, Kitchener 54%, Alphons and Baladi （30%, 28%, respectively） were the least susceptible. Also results revealed that females of both species Ceratitis cosyra and Bactrocera invadens out numbered males 4-5 times.展开更多
3D supramolecular network with considerable volume pores was created via hydrogen bond & C-H</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;&qu...3D supramolecular network with considerable volume pores was created via hydrogen bond & C-H</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">--</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">π. By </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">tightening </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">of The metal-organic frameworks (MOF) namely [Ni(μ-pmb)</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">(H</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O)</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">]</span><sub><span style="font-family:Verdana;">n</span></sub><span style="font-family:Verdana;"> (pmb = 3,5-bis(4-pyridylmethylenoxyl)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">benzoate, that have been synthesized by hydrothermal method. Complex 1 crystallizes in triclinic P-1 space group and consists of 1D semi zigzag chain.展开更多
<strong>Background:</strong> Wilm’s tumour is a cancer of the kidneys that typically occurs in children younger than fifteen years of age and rarely in adults. With an early diagnosis and proper managemen...<strong>Background:</strong> Wilm’s tumour is a cancer of the kidneys that typically occurs in children younger than fifteen years of age and rarely in adults. With an early diagnosis and proper management of Wilm’s tumour by Multi-modal approach, excellent outcome can be obtained. This study was designed to reflect the clinical presentations and focus on different management modalities with an outcome of Wilm’s tumour in Sudan. <strong>Patients and methods:</strong> This descriptive, retro-prospective analytic study included all patients of Wilm’s tumour at Soba University Hospital, Gezira national paediatric surgery centre and Khartoum teaching Hospital from January 2014 to January 2016. <strong>Results:</strong> Thirty patients (pts) were included. Females were predominant in a ratio of 3: 1 to males. The mean age was 3.0 - 5.9 years. Those who came from central and western of Sudan were more affected. Most patients presented with abdominal mass 28 pts (93.3%), followed by abdominal distension in 16 pts (53.3%), while the less frequent presentation was haematuria seen only in 2 pts (6.7%). The multimodal approach: surgery and chemotherapy used in 21 pts (70%) and single modality was used in nine patients: surgery alone in 6 pts (20%), or chemotherapy alone in 3 pts (10%). The patients discharged uneventfully 23 pts (76%). Morbidity was seen in two patients. Deaths were occurred in five patients in the study (16.7%). <strong>Conclusion:</strong> The finding of this study reflected that Wilm’s tumour has an excellent outcome when patient was managed by multimodal approach.展开更多
The nutritive value of rangelands in Southern Darfur, Sudan could be improved by introduction and multiplication of nutritious forbs with the objective of increasing livestock production in the area. The present study...The nutritive value of rangelands in Southern Darfur, Sudan could be improved by introduction and multiplication of nutritious forbs with the objective of increasing livestock production in the area. The present study was conducted to evaluate the nutritive value and palatability of eleven range forbs collected at flowering stage from Gahzal Gawazat, Southern Darfur, Sudan using chemical analysis. The crude protein (CP) ranged from 6.8% in Oxygonum atriplicifolium with lowest digestible crude protein (DCP) 2.8% to 16.4% in Zornia diphylla with highest DCP 11.73%. The highest and the lowest crude fiber (CF) values were obtained in Commelina spp (56.4%) and Sesamum alatum (25.9%), respectively. NDF and DMI values were maximum and minimum for Zornia diphylla (44.9 and 2.67%) and Alysicarpus glumaceus (35.3 and 3.4%), respectively. The total digestible nutrients (TDN) ranged from 57.1% in Blepharis linariifolia to 69.3% in Tribulus terrestris with highest digestible energy (DE) in later while the lowest DE was obtained in Commelina spp (2.4%). The calculated in vitro organic matter digestibility (IVOMD) was highest for the Canavalia ensiformis (50.27%) and lowest value (43.17%) for Commelina spp. Zornia diphylla, Tribulus terrestris and Sesamum alatum showed highest nutritive value, while Alysicarpus glumaceus, Oldenlandia senegalensis and Chrozophora brocchiana showed highest palatability. It is concluded that these rangeland forbs are palatable and their CP and energy contents are sufficient to support different classes of livestock in South Darfur, Sudan.展开更多
<span style="font-family:Verdana;">Osseous metaplasia of the breast is considered to be one of the rare breast conditions. It is characterized by the presence of normal bone tissue within the breast. W...<span style="font-family:Verdana;">Osseous metaplasia of the breast is considered to be one of the rare breast conditions. It is characterized by the presence of normal bone tissue within the breast. We report a case of benign osseous metaplasia in a 58-year-old woman presenting with mastalgia and mass in the right breast. A lumpectomy was performed. On the pathological examination, the mass was composed completely of benign bone trabeculae with no epithelial component which was confirmed by negativity of immunohistochemistry.</span>展开更多
Background: Fabella is a natural occurring sesamoid bone, cartilage or a mixture of both that is usually located at the posterolateral corner (PLC) of the knee [1]. Recently the PLC of the knee has been extensively in...Background: Fabella is a natural occurring sesamoid bone, cartilage or a mixture of both that is usually located at the posterolateral corner (PLC) of the knee [1]. Recently the PLC of the knee has been extensively investigated because it is a common site of injuries and diseases [2] [3]. The complexity of PLC anatomy needs to be fully understood because the fabella could be missed diagnosis as an osteochondral defect, osteochondritis dissecans (OCD), calcific tendinitis, or foreign body. We present a case report of fabella syndrome triggered by trauma and also performed a review of literature for the various diagnoses that might be confused with fabella syndrome. Case presentation: A 29-year-old, Sudanese male presented to the trauma center in King Khalid Hospital in KSA, complaining of pain and partial swelling in his left knee joint due to trauma. Fabella was detected in the posterior lateral corner (PLC) of the knee joint embedded in the lateral head of the gastrocnemius muscle. All other pathological conditions were excluded. Conclusion: Fabella is sesamoid bone with variable size, found in the PLC. Commonly if present it causes periodic pain especially in the fully extended knee or it remains asymptomatic. Trauma, surgery, sports or heavy extreme activities may trigger the pain of asymptomatic fabella. Clinicians should consider that pain in the PLC of the knee can result from the presence of the fabella in a condition called fabella syndrome.展开更多
Aim: This study aimed to investigate the effect of non-synonymous SNPs (nsSNPs) of the Glucagon-like peptide-1 Receptor (GLP-1R) gene in protein function and structure using different computational software. Introduct...Aim: This study aimed to investigate the effect of non-synonymous SNPs (nsSNPs) of the Glucagon-like peptide-1 Receptor (GLP-1R) gene in protein function and structure using different computational software. Introduction: The GLP1R gene provides the necessary instruction for the synthesis of the insulin hormones which is needed for glucose catabolism. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type-2 diabetes and stroke. Material and Methods: Different nsSNPs and protein-related sequences were obtained from NCBI and ExPASY database. Gene associations and interactions were predicted using GeneMANIA software. Deleterious and damaging effects of nsSNPs were analyzed using SIFT, Provean, and Polyphen-2. The association of the nsSNPs with the disease was predicted using SNPs & GO software. Protein stability was investigated using I-Mutant and MUpro software. The structural and functional impact of point mutations was predicted using Project Hope software. Project Hope analyzes the mutations according to their size, charge, hydrophobicity, and conservancy. Results: The GLP1R gene was found to have an association with 20 other different genes. Among the most important ones is the GCG (glucagon) gene which is also a trans membrane protein. Overall 7229 variants were seen, and the missense variants or nsSNPs (146) were selected for further analysis. The total number of nsSNPs obtained in this study was 146. After being subjected to SIFT software (27 Deleterious and 119 Tolerated) were predicted. Analysis with Provean showed that (20 deleterious and 7 neutral). Analysis using Polyphen-2 revealed 17 probably damaging, 2 possibly damaging and 1 benign nsSNPs. Using two additional software SNPs & GO and PHD-SNPs showed that 14 and 17 nsSNPs had a disease effect, respectively. Project Hope software predicts the effect of the 14 nsSNPs on the protein function due to differences in charge, size, hydrophobicity, and conservancy between the wild and mutant types. Conclusion: In this study, the 14 nsSNPs which were highly affected the protein function. This protein is providing the necessary instruction for the synthesis of the insulin hormones which is needed for glucose catabolism. Polymorphisms in this gene are associated with diabetes and also affect the treatment of diabetic patients due to the fact that the protein acts as an important drug target.展开更多
BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and ...BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more clarification.AIM To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state Sudan.The serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent assays.RESULTS The results showed that there was a highly statistically significant difference between the two groups(P<0.001)for all examined eight biomarkers.Whereby,leptin,luteinizing hormone(LH)/follicular stimulating hormone(FSH)ratio,prolactin hormone(PRL)and testosterone(T)were significantly higher in the UI group compared with the control group.In contrast,FSH and estradiol(E2)/T ratio were significantly lower in the UI group than in the control group and the effect size test for the difference between the two groups was very large(effect size>0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and T.CONCLUSION This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.展开更多
The objective of the present study was to evaluate the effect of feeding different levels of whole linseed,as a source of n-3 polyunsaturated fatty acids(PUFA), on ruminal fatty acid composition and microbial populati...The objective of the present study was to evaluate the effect of feeding different levels of whole linseed,as a source of n-3 polyunsaturated fatty acids(PUFA), on ruminal fatty acid composition and microbial population in the goat. Twenty-four crossbred Boer goats were assigned to 3 dietary treatments: LO(control), L10 and L20 containing 0,10%, or 20% whole linseed, respectively. The ruminal pH and concentration of total volatile fatty acids(VFA) were not affected by dietary treatments. The feeding of L10 and L20 diets produced higher(P < 0.05) molar proportions of acetate and lower(P < 0.05) molar proportions of butyrate and valerate than the LO diet. Molar proportions of myristic acid(C14:0) and palmitic acid(C16:0) were lower(P < 0.05) in the rumen of goats offered L10 and L20 diets than the control diet. However, stearic acid(C18:0), vaccenic acid(C18:1 trans-11), conjugated linoleic acid(CLA,C18:2 trans-10, cis-12) and a-lenolenic acid(C18:3 n-3) were higher(P < 0.05) in the rumen of goats fed L10 and L20 than L0. Both inclusion levels of linseed in the diet(L10 and L20) reduced the ruminal total bacteria, methanogens, and protozoa compared with LO(P < 0.05). The effect of the dietary treatments on cellulolytic bacteria, varied between the individual species. Both inclusion levels of linseed resulted in a significant decrease(P < 0.05) in the population of Fibrobacter succinogenes, and Rumunococus flavefaciens compared with LO, with no significant difference between the groups fed linseed diets. The population of Rumunococus albus was not affected by the different dietary treatments. It was concluded that inclusion of whole linseed in the diet of goats could increase the concentration of PUFA in the rumen, and decrease the population of F. succinogenes, R. flavefaciens, methanogens and protozoa in rumen liquid of goats.展开更多
This research focused on the social roles of women in Al-Abassiya locality,South Kordofan State,examining the obstacles they face and the impact on their participation in peace building.Using qualitative methods,data ...This research focused on the social roles of women in Al-Abassiya locality,South Kordofan State,examining the obstacles they face and the impact on their participation in peace building.Using qualitative methods,data were collected through various means,revealing that conflicts have significantly affected women’s lives,particularly in rural areas.Women play key roles in family,education,health services,and humanitarian aid,but their involvement in conflict resolution and peace building activities is limited.Obstacles include cognitive,economic,social,and institutional barriers.Recommendations include providing education and training programs,strengthening economic status,ensuring women’s representation in decision-making bodies,advocating for legal reforms promoting gender equality,improving access to information technologies,educating communities on women’s involvement in peace building,and providing support services for women affected by conflicts.展开更多
文摘A detailed quantum mechanical analysis of electronic disposition of five aminopyrimidoisoquinolinequinones (APIQs) was performed after extraction of this subset of compounds from a larger data set of APIQs via a reported clustering methodology (Elfaki, et al. 2020). Both semi empirical PM3 method and DFT quantum mechanical methods were used to calculate global and local quantum mechanical descriptors (QMDs) to define the electronic environment of these molecules in attempt to rationalize their observed anti-cancer response variability. The biological response is the anticancer activity against human gastric adenocarcenoma (AGS) cell line. The correlation matrix between the calculated global electronic descriptors and biological activity demonstrated that the global dipole moment gives the highest correlation. The local electronic environment was analysed by The Mullikan charges (MC) and Fukui functions for N-5, C-6, C-8 in addition to the N atom of phenylamino side group at C-8. MCs furnished no useful information as each of these atoms had almost identical MC values for all the five compounds with exception of C-6 which gave varied values. Regressing MCs of C-6 against the response traces 60% of the latter variability. As C-6 is an extra annular methyl carbon adjacent to N-5 in isoquinoline residue of APIQ, we reasoned that the chemical reactivities of 4 out of the 5 APIQs might be due to a Chichibabin-type tautomerism implying a possible alkylation aspect in their mechanism of action. The corresponding Fukui functions (f<sup>-</sup>, f<sup>+</sup> and f<sup>0</sup>) showed a considerable consistency with the patterns of chemical reactivity exhibited by this small set of APIQs.
文摘Background: Hypocalcaemia is a serious complication that may follows thyroid surgeries. So, the purpose of this study was to determine the frequency of postoperative hypocalcaemia after thyroid surgery in Omdurman military hospital (Jan.-July 2018). Materials & Methods: In this retrospective facility based cross sectional study, 124 files were reviewed, the recorded data were age, sex, residence, diagnosis, type of surgery & postoperative calcium level, data were collected by a designed pretested checklist, data were analyzed by SPSS version 20 by using frequencies & cross tabulations, for postoperative hypocalcaemia. Results: Majority of the patients were between 21 - 41 years 49.2%, majority of them were females 83.9%. 97.6% of them underwent total thyroidectomy, 25% of the patients developed postoperative hypocalcaemia, also we found that there was no relation between sex, type of thyroid surgery & development of postoperative hypocalcaemia (P > 0.001). Conclusion: Our research showed that 25% of the patients who underwent thyroid surgery developed postoperative hypocalcaemia.
文摘In this paper, which serves as a continuation of earlier work, we generalize the idea of inequalities in metric spaces and use them to demonstrate that the incomplete metric space can be used to obtain a Banach space.
文摘Carissa edulis Vahl is well known in Sudanese herbal medicine,commonly used for treatment of epilepsy,headache,chest pains,rheumatism,skin lesions,mania and other psychoactive diseases.The investigations of the safety use for psychoactive purposes in Sudanese healing traditions and identifying secondary metabolites of the plant extracts are the key steps towards determination of appropriate medicinal doses.Therefore,one of the chemical constituents was isolated and structurally identified by 1H-NMR and LC-MS.With the aim of evaluating Carissa edulis folk random uses,the isolated compound was compared with reference artificial drugs Lormetazepam,a potentially toxic compound.Structure investigations confirm that the isolated product was benzodiazepines analogous 7-chloro 1,4-benzodiazepine-2-ones.It is important to know the potential toxicity of certain plant in order to assess the therapeutic effect of it,as these are slight distinctions between the medicinal and toxic doses.In general the results obtained justify the use of the roots of Carissa edulis in traditional medicine for the treatment of some psychiatric diseases.
文摘This study was carried out to assess the leaves and fruits of Grewia mollis, Grewia tenax and Grewia villosa for their potentials to produce high nutritive value fodder under semi-arid conditions. The experiment was conducted at the farm of the College of Natural Resources and Environmental Studies, University of Juba-Khartoum-Sudan. Randomized Complete Block design with three replications was used. Proximate analysis was carried to estimate nutritive value, and mineral contents of leaves, seeds and fruit pulp of the three species. Results indicated significant difference （P ≤ 0.05） in nutritive value of the leaves among the three species; dry matter, ash, and acid detergent factor （ADF） kg/ha, while no significant difference was observed among the species in crude protein （CP） and nutrient detergent factor （NDF） kg/ha. Mineral contents of the leaves of the three species showed variations among the species and seasons. Seeds and fruit pulp were found to have considerable levels of nutrients and mineral contents. The nutritive value of the three species was higher in the rainy season compared to the dry season. The results of this study indicate that the three species can be introduced as a source of fodder in animal production farms and silvopastural systems.
文摘This study was carried out to assess the growth characteristics of Grewia moll＆, Grewia tenax and Grewia villosa under the nursery and field conditions. Two experiments were conducted at the farm of the College of Natural Resources and Environmental Studies, University of Juba, Khartoum, Sudan. Randomized complete block design with three replications was used. Morphological and physiological factors were measured. Seedlings height, number of leaves, number of branches and sub-branches were different （P 〈 0.05） among the three species at the nursery stage and under field conditions. Collar diameter showed significant difference among the species under field conditions. Physiological factors exhibited more significant variations in the field than at the nursery stage. Variations in growth characteristics were attributed to genetics differences and different growth habit, while variations in physiological factors （photosynthesis and transpiration rate） were attributed to differences in leaf structure, size and number of stomatal pores.
文摘Background: The chemical composition of gallstones is essential to study aetiopathogenesis of gallstone disease. Objective: To determine the composition of gallstones in a Sudanese population. Patients and methods: It describes an extensive quantitative analysis of gallstones from patients presented with symptomatic gall stone disease and treated by cholecystectomy after the acceptance of the pre-given informed consent in Khartoum teaching hospital in the period between Jan 2010 and Dec 2010. Using a pretested questionnaire data collected from and analyzed statistically by SPSS computer program version 21. Results: Data are analyzed from 94 patients (six males and 88 females). Cholesterol stones showed a significantly higher cholesterol content than pigment stones (p = 0.0042), though not significantly higher than mixed stones. Their phospholipids content and inorganic phosphates were higher than in the other types of stones and oxalate content was significantly elevated in comparison with mixed stones (p = 0.0402). In mixed stones, the cholesterol, bile acids, and bilirubin were intermediate between cholesterol and pigment stones, whereas triglycerides were significantly more than pigment stones (p = 0.0007). Bilirubin (p = 0.0021) and bile acids (p = 0.0016) were significantly higher than cholesterol stones (p = 0.0001) and (p = 0.0001) respectively. However, they contained the lowest amounts of sodium, potassium, magnesium, and oxalate. In pigment stones, bilirubin was significantly higher (p = 0.0001) than both groups. Conclusion: Collaborations between surgeons, nutritionists, biochemists, and physicians should be stimulated in future studies to define the different types of gall stones in different areas in Sudan and the relevancy of such types with diets’ traditions.
文摘A serological survey of Toxoplasma gondii was conducted using LAT （Latex Agglutination Test） on 205 sera collected from working horses and donkeys in Khartoum State, Sudan. The overall sero-prevalence of the investigated equines was 32.7%. Antibodies to T. gondii were found in 38% of 100 horses and 27.6% of 105 donkeys. The titers were 1：2 （4 heads）, 1：4 （11 heads）, 1：8 （13 heads）, 1：16 （17 heads）, 1：32 （5 heads）, 1：64 （10 donkeys） and 1：128 （7 donkeys）. Neither the area nor animal species showed significant differences between the investigated groups. However, age was reported to show significant （P 〈 0.05） effect on equine toxoplasmosis in the Sudan. This is the first report on equine toxoplasmosis in the Sudan.
文摘Toxoplasmosis is an important cause of reproductive failure in man and farm animals resulting in significant socio-economic losses worldwide. The aim of this study was to avail large scale data-regarding the sero-prevalence of T. gondii infection in dairy animals from the Khartoum State, Sudan using the commercially available Latex Agglutination Diagnostic kits. The study revealed that the overall seroprevalence of T. gondii infection at herd level of dairy animals in the State was 92.7%. The within herd seroprevalence was ranging from 8% up to 100% with mean of 51.3% in different herds of different dairy animals species in the State. Only 6 herds, 3 herds, 3 herds and 1 herd of cattle, camel sheep and goat respectively were found to be clean from anti-T, gondii antibody in the present study. Interestingly, most of the clean herds （12 herds） are located in the Khartoum district. The differences between the three districts, the seven localities and the four animal species were statistically highly significant （P 〈 0.01）. The overall sero-prevalence of T. gondii infection in dairy animals--at individual level--was 45.3%. Sheep scored the highest seroprevalence rate （75.0%） followed by goats （64.0%）, camels （54.1%） and cattle （40.9%） with high statistically significant differences （P 〈 0.01）. The highest level of antibody titration was reported in sheep and goats. This is the first area-wide and large scale report on seroprevalence of T. gondii infection in dairy animals from the Sudan. It was concluded that dairy animals in the Sudan are widely exposed to T. gondii and people in the Sudan should be aware of the possibility of hyper-prevalence of human toxoplasmosis through these food animals. Research on clinical toxoplasmosis in dairy animals and human in the Sudan is recommended to evaluate the role T. gondii infection in economical losses in dairy farm industry and for building strategy of sustainable toxoplasmosis control.
文摘A seroprevalence investigation of human brucellosis was carried out in Kuku Dairy Scheme, Sudan. A total of 176 serum samples were collected and screened by Rose Bengal Plate Test （RBPT）. The positive sera vqere further examined using Tube Agglutination Test （TAT） and c-Elisa. The seropositivity was 15.9%, 14.8% and 11.4% using RBPT, TAT and c-Elisa respectively. Whereas, the active infection based on seropositivity and clinical signs were 4.6%, 4.6% and 2.3% in case of RBPT, TAT and c-Elisa respectively. Based on c-Elisa result the infected individuals were further subjected to clinical examination and treated with streptomycin and doxocycline for six weeks.
文摘Fruit flies are serious pests of Mango in Sudan; they cause substantial damage to Mango production, both qualitatively and quantitatively. This study is an effort to establish information about the pest and, to test the susceptibility of some Mango cultivars （Baladi, Kitchener, Shendi, Alphons, Abu Samaka and Bit abusamaka） to the pest infestation. A survey was carded out at Shendi area, River Nile State, during the period of May 2007 to July 2008, using a home made trap resemble lvnfield traps with attractants （Methyl eugenol, Trimedlure, cue lure and Nu lure） to identify the fruit flies species found in the area and to study the seasonal abundance of the pest species and to determine the infestation percentage of different Mango cultivars. Results indicated that the fruit fly Bactrocera invadens is present all year-round in the study area, with population peak July to September. The study showed that Guava （ Psedium guajava ） represents the best alternative host for the pest. Abu samaka and Bit Abusa amaka mango cultivars were the most susceptible, with 100% infestation, followed by Shendi 70%, Kitchener 54%, Alphons and Baladi （30%, 28%, respectively） were the least susceptible. Also results revealed that females of both species Ceratitis cosyra and Bactrocera invadens out numbered males 4-5 times.
文摘3D supramolecular network with considerable volume pores was created via hydrogen bond & C-H</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">--</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">π. By </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">tightening </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">of The metal-organic frameworks (MOF) namely [Ni(μ-pmb)</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">(H</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O)</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">]</span><sub><span style="font-family:Verdana;">n</span></sub><span style="font-family:Verdana;"> (pmb = 3,5-bis(4-pyridylmethylenoxyl)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">benzoate, that have been synthesized by hydrothermal method. Complex 1 crystallizes in triclinic P-1 space group and consists of 1D semi zigzag chain.
文摘<strong>Background:</strong> Wilm’s tumour is a cancer of the kidneys that typically occurs in children younger than fifteen years of age and rarely in adults. With an early diagnosis and proper management of Wilm’s tumour by Multi-modal approach, excellent outcome can be obtained. This study was designed to reflect the clinical presentations and focus on different management modalities with an outcome of Wilm’s tumour in Sudan. <strong>Patients and methods:</strong> This descriptive, retro-prospective analytic study included all patients of Wilm’s tumour at Soba University Hospital, Gezira national paediatric surgery centre and Khartoum teaching Hospital from January 2014 to January 2016. <strong>Results:</strong> Thirty patients (pts) were included. Females were predominant in a ratio of 3: 1 to males. The mean age was 3.0 - 5.9 years. Those who came from central and western of Sudan were more affected. Most patients presented with abdominal mass 28 pts (93.3%), followed by abdominal distension in 16 pts (53.3%), while the less frequent presentation was haematuria seen only in 2 pts (6.7%). The multimodal approach: surgery and chemotherapy used in 21 pts (70%) and single modality was used in nine patients: surgery alone in 6 pts (20%), or chemotherapy alone in 3 pts (10%). The patients discharged uneventfully 23 pts (76%). Morbidity was seen in two patients. Deaths were occurred in five patients in the study (16.7%). <strong>Conclusion:</strong> The finding of this study reflected that Wilm’s tumour has an excellent outcome when patient was managed by multimodal approach.
文摘The nutritive value of rangelands in Southern Darfur, Sudan could be improved by introduction and multiplication of nutritious forbs with the objective of increasing livestock production in the area. The present study was conducted to evaluate the nutritive value and palatability of eleven range forbs collected at flowering stage from Gahzal Gawazat, Southern Darfur, Sudan using chemical analysis. The crude protein (CP) ranged from 6.8% in Oxygonum atriplicifolium with lowest digestible crude protein (DCP) 2.8% to 16.4% in Zornia diphylla with highest DCP 11.73%. The highest and the lowest crude fiber (CF) values were obtained in Commelina spp (56.4%) and Sesamum alatum (25.9%), respectively. NDF and DMI values were maximum and minimum for Zornia diphylla (44.9 and 2.67%) and Alysicarpus glumaceus (35.3 and 3.4%), respectively. The total digestible nutrients (TDN) ranged from 57.1% in Blepharis linariifolia to 69.3% in Tribulus terrestris with highest digestible energy (DE) in later while the lowest DE was obtained in Commelina spp (2.4%). The calculated in vitro organic matter digestibility (IVOMD) was highest for the Canavalia ensiformis (50.27%) and lowest value (43.17%) for Commelina spp. Zornia diphylla, Tribulus terrestris and Sesamum alatum showed highest nutritive value, while Alysicarpus glumaceus, Oldenlandia senegalensis and Chrozophora brocchiana showed highest palatability. It is concluded that these rangeland forbs are palatable and their CP and energy contents are sufficient to support different classes of livestock in South Darfur, Sudan.
文摘<span style="font-family:Verdana;">Osseous metaplasia of the breast is considered to be one of the rare breast conditions. It is characterized by the presence of normal bone tissue within the breast. We report a case of benign osseous metaplasia in a 58-year-old woman presenting with mastalgia and mass in the right breast. A lumpectomy was performed. On the pathological examination, the mass was composed completely of benign bone trabeculae with no epithelial component which was confirmed by negativity of immunohistochemistry.</span>
文摘Background: Fabella is a natural occurring sesamoid bone, cartilage or a mixture of both that is usually located at the posterolateral corner (PLC) of the knee [1]. Recently the PLC of the knee has been extensively investigated because it is a common site of injuries and diseases [2] [3]. The complexity of PLC anatomy needs to be fully understood because the fabella could be missed diagnosis as an osteochondral defect, osteochondritis dissecans (OCD), calcific tendinitis, or foreign body. We present a case report of fabella syndrome triggered by trauma and also performed a review of literature for the various diagnoses that might be confused with fabella syndrome. Case presentation: A 29-year-old, Sudanese male presented to the trauma center in King Khalid Hospital in KSA, complaining of pain and partial swelling in his left knee joint due to trauma. Fabella was detected in the posterior lateral corner (PLC) of the knee joint embedded in the lateral head of the gastrocnemius muscle. All other pathological conditions were excluded. Conclusion: Fabella is sesamoid bone with variable size, found in the PLC. Commonly if present it causes periodic pain especially in the fully extended knee or it remains asymptomatic. Trauma, surgery, sports or heavy extreme activities may trigger the pain of asymptomatic fabella. Clinicians should consider that pain in the PLC of the knee can result from the presence of the fabella in a condition called fabella syndrome.
文摘Aim: This study aimed to investigate the effect of non-synonymous SNPs (nsSNPs) of the Glucagon-like peptide-1 Receptor (GLP-1R) gene in protein function and structure using different computational software. Introduction: The GLP1R gene provides the necessary instruction for the synthesis of the insulin hormones which is needed for glucose catabolism. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type-2 diabetes and stroke. Material and Methods: Different nsSNPs and protein-related sequences were obtained from NCBI and ExPASY database. Gene associations and interactions were predicted using GeneMANIA software. Deleterious and damaging effects of nsSNPs were analyzed using SIFT, Provean, and Polyphen-2. The association of the nsSNPs with the disease was predicted using SNPs & GO software. Protein stability was investigated using I-Mutant and MUpro software. The structural and functional impact of point mutations was predicted using Project Hope software. Project Hope analyzes the mutations according to their size, charge, hydrophobicity, and conservancy. Results: The GLP1R gene was found to have an association with 20 other different genes. Among the most important ones is the GCG (glucagon) gene which is also a trans membrane protein. Overall 7229 variants were seen, and the missense variants or nsSNPs (146) were selected for further analysis. The total number of nsSNPs obtained in this study was 146. After being subjected to SIFT software (27 Deleterious and 119 Tolerated) were predicted. Analysis with Provean showed that (20 deleterious and 7 neutral). Analysis using Polyphen-2 revealed 17 probably damaging, 2 possibly damaging and 1 benign nsSNPs. Using two additional software SNPs & GO and PHD-SNPs showed that 14 and 17 nsSNPs had a disease effect, respectively. Project Hope software predicts the effect of the 14 nsSNPs on the protein function due to differences in charge, size, hydrophobicity, and conservancy between the wild and mutant types. Conclusion: In this study, the 14 nsSNPs which were highly affected the protein function. This protein is providing the necessary instruction for the synthesis of the insulin hormones which is needed for glucose catabolism. Polymorphisms in this gene are associated with diabetes and also affect the treatment of diabetic patients due to the fact that the protein acts as an important drug target.
基金the Pan African University of Life and Earth Sciences Institutethe African Union for financial supportthe University of Ibadan for hosting this Ph D program
文摘BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more clarification.AIM To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state Sudan.The serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent assays.RESULTS The results showed that there was a highly statistically significant difference between the two groups(P<0.001)for all examined eight biomarkers.Whereby,leptin,luteinizing hormone(LH)/follicular stimulating hormone(FSH)ratio,prolactin hormone(PRL)and testosterone(T)were significantly higher in the UI group compared with the control group.In contrast,FSH and estradiol(E2)/T ratio were significantly lower in the UI group than in the control group and the effect size test for the difference between the two groups was very large(effect size>0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and T.CONCLUSION This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.
文摘The objective of the present study was to evaluate the effect of feeding different levels of whole linseed,as a source of n-3 polyunsaturated fatty acids(PUFA), on ruminal fatty acid composition and microbial population in the goat. Twenty-four crossbred Boer goats were assigned to 3 dietary treatments: LO(control), L10 and L20 containing 0,10%, or 20% whole linseed, respectively. The ruminal pH and concentration of total volatile fatty acids(VFA) were not affected by dietary treatments. The feeding of L10 and L20 diets produced higher(P < 0.05) molar proportions of acetate and lower(P < 0.05) molar proportions of butyrate and valerate than the LO diet. Molar proportions of myristic acid(C14:0) and palmitic acid(C16:0) were lower(P < 0.05) in the rumen of goats offered L10 and L20 diets than the control diet. However, stearic acid(C18:0), vaccenic acid(C18:1 trans-11), conjugated linoleic acid(CLA,C18:2 trans-10, cis-12) and a-lenolenic acid(C18:3 n-3) were higher(P < 0.05) in the rumen of goats fed L10 and L20 than L0. Both inclusion levels of linseed in the diet(L10 and L20) reduced the ruminal total bacteria, methanogens, and protozoa compared with LO(P < 0.05). The effect of the dietary treatments on cellulolytic bacteria, varied between the individual species. Both inclusion levels of linseed resulted in a significant decrease(P < 0.05) in the population of Fibrobacter succinogenes, and Rumunococus flavefaciens compared with LO, with no significant difference between the groups fed linseed diets. The population of Rumunococus albus was not affected by the different dietary treatments. It was concluded that inclusion of whole linseed in the diet of goats could increase the concentration of PUFA in the rumen, and decrease the population of F. succinogenes, R. flavefaciens, methanogens and protozoa in rumen liquid of goats.
基金The researcher would like to thank Dr.Afag Mohamed Sadig as supervisor and Prof Hazel Barrett as co-supervisor for the paper。
文摘This research focused on the social roles of women in Al-Abassiya locality,South Kordofan State,examining the obstacles they face and the impact on their participation in peace building.Using qualitative methods,data were collected through various means,revealing that conflicts have significantly affected women’s lives,particularly in rural areas.Women play key roles in family,education,health services,and humanitarian aid,but their involvement in conflict resolution and peace building activities is limited.Obstacles include cognitive,economic,social,and institutional barriers.Recommendations include providing education and training programs,strengthening economic status,ensuring women’s representation in decision-making bodies,advocating for legal reforms promoting gender equality,improving access to information technologies,educating communities on women’s involvement in peace building,and providing support services for women affected by conflicts.
