TToo tthhee eeddiittoorr::Eating disorder(ED),as defined by the Diagnostic and Statistical Manual of Mental Disorders(DSM-5),is a persistent disturbance of eating or eating-related behaviour that results in the altere...TToo tthhee eeddiittoorr::Eating disorder(ED),as defined by the Diagnostic and Statistical Manual of Mental Disorders(DSM-5),is a persistent disturbance of eating or eating-related behaviour that results in the altered consumption or absorption of food and that significantly impairs physical health or psychosocial functioning.^(1)The DSM-5 outlines criteria for EDs,including anorexia nervosa,bulimia nervosa,binge-eating disorder,pica,rumination disorder and avoidant/restrictive food intake disorder.EDs are relatively common in young people,affecting 5.5%-17.9%of young women and 0.6%-2.4%of young men by the time they reach early adulthood.展开更多
AIM To investigate technical feasibility, outcomes and adverse events of the lumen-apposing metal stent(LAMS) for benign gastrointestinal(GI) tract strictures.METHODS Between July 2015 and January 2017, patients under...AIM To investigate technical feasibility, outcomes and adverse events of the lumen-apposing metal stent(LAMS) for benign gastrointestinal(GI) tract strictures.METHODS Between July 2015 and January 2017, patients undergoing treatment by LAMS for benign GI strictures at three tertiary referral centers were included in this study. Primary outcomes included technical success, shortterm clinical success, long-term clinical success, and adverse events. Short-term clinical success was defined as symptom resolution at 30 d after stent placement. Longterm clinical success was defined by symptom resolution at 60 d in patients who continued to have indwelling stent, or continued symptom resolution at 30 d after elective stent removal.RESULTS A total of 21 patients(mean age 62.6 years, 47.6% males) underwent placement of LAMS for benign GI strictures. A 15 mm × 10 mm LAMS was placed in 16 patients, a 10 mm × 10 mm LAMS was placed in 2 patients, and a 16 mm × 30 mm LAMS was placed in 3 patients. Technical success was obtained in all cases. Short-term clinical success was achieved in 19 out of 21 cases(90.5%), and long-term clinical success was achieved in 12 out of 18(66.7%). Mean(range) stent indwell time was 107.2(28-370) d. After a mean(range) dwell time of 104.3(28-306) d, 9 LAMSs were removed due to the following complications: ulceration at stent site(n = 1), angulation(n = 2), migration(n = 4) and stricture overgrowth(n = 2). Migration occurred in 4 cases(19.0%), and it was associated with stricture resolution in one case. Median(range) follow-up period was 119(31-422) d. CONCLUSION Utilization of LAMS for benign strictures has shown to be technically feasible and safe, but adverse events highlight the need for further study of its indications.展开更多
基金Funding Effort for some personnel was supported by grants K12 DA041449(KYX,PI:Laura Bierut,Patricia Cavazos-Rehg),and the American Psychiatric Association Psychiatric Research Fellowship(KYX).Authors BYL and C-FS were American Psychiatric Association(APA)/APA Foundation(APAF)fellows at the time of publication.Research grant funding received from Gilead Pharmaceuticals,Liva Nova Therapeutics,Curemark and Alto Neuroscience(ASK).
文摘TToo tthhee eeddiittoorr::Eating disorder(ED),as defined by the Diagnostic and Statistical Manual of Mental Disorders(DSM-5),is a persistent disturbance of eating or eating-related behaviour that results in the altered consumption or absorption of food and that significantly impairs physical health or psychosocial functioning.^(1)The DSM-5 outlines criteria for EDs,including anorexia nervosa,bulimia nervosa,binge-eating disorder,pica,rumination disorder and avoidant/restrictive food intake disorder.EDs are relatively common in young people,affecting 5.5%-17.9%of young women and 0.6%-2.4%of young men by the time they reach early adulthood.
文摘AIM To investigate technical feasibility, outcomes and adverse events of the lumen-apposing metal stent(LAMS) for benign gastrointestinal(GI) tract strictures.METHODS Between July 2015 and January 2017, patients undergoing treatment by LAMS for benign GI strictures at three tertiary referral centers were included in this study. Primary outcomes included technical success, shortterm clinical success, long-term clinical success, and adverse events. Short-term clinical success was defined as symptom resolution at 30 d after stent placement. Longterm clinical success was defined by symptom resolution at 60 d in patients who continued to have indwelling stent, or continued symptom resolution at 30 d after elective stent removal.RESULTS A total of 21 patients(mean age 62.6 years, 47.6% males) underwent placement of LAMS for benign GI strictures. A 15 mm × 10 mm LAMS was placed in 16 patients, a 10 mm × 10 mm LAMS was placed in 2 patients, and a 16 mm × 30 mm LAMS was placed in 3 patients. Technical success was obtained in all cases. Short-term clinical success was achieved in 19 out of 21 cases(90.5%), and long-term clinical success was achieved in 12 out of 18(66.7%). Mean(range) stent indwell time was 107.2(28-370) d. After a mean(range) dwell time of 104.3(28-306) d, 9 LAMSs were removed due to the following complications: ulceration at stent site(n = 1), angulation(n = 2), migration(n = 4) and stricture overgrowth(n = 2). Migration occurred in 4 cases(19.0%), and it was associated with stricture resolution in one case. Median(range) follow-up period was 119(31-422) d. CONCLUSION Utilization of LAMS for benign strictures has shown to be technically feasible and safe, but adverse events highlight the need for further study of its indications.
