At present,there is a certain understanding of gout combined with diabetes in traditional Chinese medicine,but most studies are related to diabetes combined with hyperuricemia,while few studies are related to gout com...At present,there is a certain understanding of gout combined with diabetes in traditional Chinese medicine,but most studies are related to diabetes combined with hyperuricemia,while few studies are related to gout combined with diabetes.In this paper,the research progress of western medicine in the treatment of gout combined with diabetes is summarized and the research progress of Chinese medicine or integrated Chinese and western medicine in the treatment of gout combined with diabetes is explored.展开更多
External application of traditional Chinese medicine has a long history and definite curative effect on gout.By searching the latest literature on the treatment of acute gouty arthritis by external treatment of tradit...External application of traditional Chinese medicine has a long history and definite curative effect on gout.By searching the latest literature on the treatment of acute gouty arthritis by external treatment of traditional Chinese medicine,the research progress of external treatment of acute gouty arthritis in recent years was summarized.According to the existing research results,the external treatment of Chinese medicine in the treatment of acute gout has better efficacy and higher safety,and has a broad application prospect.展开更多
Objective:Red blood cell distribution width(RDW)has been utilized as a prognostic indicator for mortality risk assessment in cardiovascular and cerebrovascular patients.Nevertheless,the prognostic significance of RDW ...Objective:Red blood cell distribution width(RDW)has been utilized as a prognostic indicator for mortality risk assessment in cardiovascular and cerebrovascular patients.Nevertheless,the prognostic significance of RDW in critically ill patients with cerebral infarction is yet to be investigated.The objective of this study is to examine the association between RDW and the risk of all-cause mortality in cerebral infarction patients admitted to the intensive care unit(ICU).Method:A retrospective cohort study was conducted using the Medical Information Mart for Intensive Care IV 2.2(MIMIC-IV)intensive care dataset for data analysis.The main results were the all-cause mortality rates at 3 and 12 months of follow-up.Cumulative curves were plotted using the Kaplan-Meier method,and Cox proportional hazards analysis was used to examine the relationship between RDW and mortality rates in critically ill cerebral infarction patients.Results:The findings indicate that RDW serves as a significant prognostic factor for mortality risk in critically ill stroke patients,specifically at the 3 and 12-month follow-up periods.The observed correlation between increasing RDW levels and higher mortality rates among cerebral infarction patients further supports the potential utility of RDW as a predictive indicator.Conclusion:RDW emerges as an independent predictor of mortality risk during the 3 and 12-month follow-up periods for critically ill patients with cerebral infarction.展开更多
The Chinese medicine compound, Jisuikang, can promote recovery of neurological function by inhibiting lipid peroxidation, scavenging oxygen free radicals, and effectively improving the local microenvironment after spi...The Chinese medicine compound, Jisuikang, can promote recovery of neurological function by inhibiting lipid peroxidation, scavenging oxygen free radicals, and effectively improving the local microenvironment after spinal cord injury. However, the mechanism remains unclear. Thus, we established a rat model of acute spinal cord injury using a modified version of Allen's method. Jisuikang(50, 25, and 12.5 g/kg/d) and prednisolone were administered 30 minutes after anesthesia. Basso, Beattie, and Bresnahan locomotor scale scores and the oblique board test showed improved motor function recovery in the prednisone group and moderate-dose Jisuikang group compared with the other groups at 3–7 days post-injury. The rats in the moderate-dose Jisuikang group recovered best at 14 days post-injury. Hematoxylin-eosin staining and transmission electron microscopy showed that the survival rate of neurons in treatment groups increased after 3–7 days of administration. Further, the structure of neurons and glial cells was more distinct, especially in prednisolone and moderate-dose Jisuikang groups. Western blot assay and immunohistochemistry showed that expression of brain-derived neurotrophic factor(BDNF) in injured segments was maintained at a high level after 7–14 days of treatment. In contrast, expression of nerve growth factor(NGF) was down-regulated at 7 days after spinal cord injury. Real-time fluorescence quantitative polymerase chain reaction showed that expression of BDNF and NGF m RNA was induced in injured segments by prednisolone and Jisuikang. At 3–7 days after injury, the effect of prednisolone was greater, while 14 days after injury, the effect of moderate-dose Jisuikang was greater. These results confirm that Jisuikang can upregulate BDNF and NGF expression for a prolonged period after spinal cord injury and promote repair of acute spinal cord injury, with its effect being similar to prednisolone.展开更多
AIM:To evaluate the effects of angiopoietin-1(Ang-1) on adhesion of gastric cancer cell line BGC-823 and expression of integrinβ1,CD44V6,urokinase-type plasminogen activator(uPA)and matrix metalloproteinase-2(MMP-2)....AIM:To evaluate the effects of angiopoietin-1(Ang-1) on adhesion of gastric cancer cell line BGC-823 and expression of integrinβ1,CD44V6,urokinase-type plasminogen activator(uPA)and matrix metalloproteinase-2(MMP-2). METHODS:BGC-823 cells were transfected transiently with adenovirus-Ang-1(Ad-Ang-1).Cells transfected transiently with adenovirus-green fluorescent protein (Ad-GFP)and untransfected cells were used as a negative and blank control group,respectively.The cell adhesion rate between cell and extracellular matrix(ECM)was determined by cell adhesion assay. To investigate whether Ang-1 could reinforce gastric carcinoma metastasis,we performed migration and invasion assays in BGC-823 cells.The mRNA and protein expression of integrinβ1,CD44V6,uPA and MMP-2 were detected by reverse transcription polymerasechain reaction and Western blotting,respectively.The expression of integrinβ1 and CD44V6 was measured by immunohistochemistry. RESULTS:BGC-823 cells were transfected successfully. The adhesion rate increased significantly in the Ad- Ang-1 group(P<0.05).The Ad-Ang-1-transfected group had a significant increase in migration and invasion compared with that of the mock-transfected and Ad-GFP groups.The mRNA and protein expression of integrinβ1,CD44V6,uPA and MMP-2 in the Ad-Ang-1 group was higher than that in the Ad-GFP and blank control groups(P<0.05).Compared with mock- transfected and Ad-GFP groups,integrinβ1 and CD44V6 expression intensity greatly increased(P<0.05). CONCLUSION:Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrinβ1 and CD44V6,by which cell adhesion and metastasis to the ECM are promoted.展开更多
Gout is an independent risk factor for hypertension,diabetes mellitus,hyperlipidemia,coronary heart disease and cerebral infarction.At present,the studies on the mechanism of gout at home and abroad have mainly focuse...Gout is an independent risk factor for hypertension,diabetes mellitus,hyperlipidemia,coronary heart disease and cerebral infarction.At present,the studies on the mechanism of gout at home and abroad have mainly focused on immune inflammation,gene polymorphism and related studies.Uric acid deposition or crystal precipitation activates phagocytes,fibroblasts and mast cells in synovium,produces IL-1β,TNF and chemokine IL-8(CXCL8),thereby activating neutrophils,urate crystal polyanion surface can be coated with immunoglobulins and other serum proteins as substrates for complement activation,complement substitution pathways and classical complement pathways to activate complements.Uric acid crystals activate inflammation-related signal transduction pathways including the activation of inflammation-related signal transduction pathway by uric acid crystals and TLRS/MyD88 signal transduction pathways.Gene polymorphism is related to inflammation and signaling pathway,EGF gene is closely related to gout inflammation,which may be involved in the regulation of gout inflammation,among which NLRP3 inflammatory signaling pathway and gene polymorphism have been deeply studied in the pathogenesis of gout,which is the main therapeutic target of anti-inflammatory and uric acid lowering.展开更多
More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NO...More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NOTOPTERYGII,os tigris,RADIX ASTRAGALI,RADIX SAPOSHNIKOVIAE,Prepared common monkshood daughter root,doubleteeth pubescent angelica root,RADIX ANGELICAE SINENSIS,frankincense,RADIX STEPHANIAE TETRANDRAE,RADIX ACHYRANTHIS BIDENTATAE,myrrh,RADIX ACONITI、RADIX DIPSACI,RHIZOMA GASTRODIAE,ginseng root,HERBA DENDROBII,CORNU SAIGAE TATARICAE,RADIX MORINDAE OFFICINALIS,PORIA,SEMEN COICIS,poison yam,and so on.It basically reflected the ancient and modern treatment of Bi syndrome in traditional Chinese medicine named after the formula.展开更多
More than 30 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome from Zang and Fu were collected,summarized and analyzed,and the theory of treating arthralg...More than 30 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome from Zang and Fu were collected,summarized and analyzed,and the theory of treating arthralgia syndrome from Zang and Fu in the lung,spleen,liver and kidney basically reflected the academic thought of treating Bi syndrome from the viscera in traditional Chinese medicine books.展开更多
The literatures in more than 40 medical history books and classical medical works about TCM name and classification of Bi syndrome were systematically sorted out,summarized and analyzed,which basically reflected the a...The literatures in more than 40 medical history books and classical medical works about TCM name and classification of Bi syndrome were systematically sorted out,summarized and analyzed,which basically reflected the academic origin of Bi syndrome in ancient and modern Chinese medicine.Through the research on the academic origin of the nomenclature of arthralgia syndrome in traditional Chinese medicine,the changes of the nomenclature of arthralgia syndrome in traditional Chinese medicine were clearly grasped,which was of great significance for the further standardization of the nomenclature of arthralgia syndrome.展开更多
More than 40 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome treated from eliminating pathogen and strengthening vital qi were sorted out,summarized and...More than 40 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome treated from eliminating pathogen and strengthening vital qi were sorted out,summarized and analyzed,and the theory of treating arthralgia syndrome from eliminating pathogenic factors including dampness,heat,cold,phlegm and blood stasis,and strengthening vital qi basically reflected the academic thought of treating Bi syndrome from eliminating pathogen and strengthening vital qi in traditional Chinese medicine books.展开更多
Rheumatoid arthritis(RA)belongs to the category of"bi syndrome(arthralgia syndrome)"in traditional Chinese medicine(TCM).According to the characteristics of clinical symptoms,there are descriptions of"b...Rheumatoid arthritis(RA)belongs to the category of"bi syndrome(arthralgia syndrome)"in traditional Chinese medicine(TCM).According to the characteristics of clinical symptoms,there are descriptions of"bone bi(bone arthralgia)","arthroncus of knee"and"drumstick wind"in TCM.Modern physicians have studied the etiology,pathogenesis and treatment of RA from the treatment of the viscera,including the treatment from the spleen,liver and kidney,treatment from ying(nutrient)and wei(defense),and treatment from ethnic medicine by drawing on the theories of ancient physicians and clinical experience.展开更多
Objective: To investigate the effect of Compound Tegafur and Oteracil Potassium Sustained Capsules (S-1) combined with oxaliplatin chemotherapy on serum tumor marker matrix metalloproteinase and immune function in eld...Objective: To investigate the effect of Compound Tegafur and Oteracil Potassium Sustained Capsules (S-1) combined with oxaliplatin chemotherapy on serum tumor marker matrix metalloproteinase and immune function in elderly patients with gastric cancer. Methods:According to the random data table, 80 cases of elderly patients with gastric cancer were divided into control group and observation group (n=40), patients in the control group were treated with oxaliplatin combined with Capecitabine Tablets, and the observation group patients were treated with S-1 combined with oxaliplatin, all treated for 6 cycles, before and after treatment, levels of serum tumor markers, matrix metalloproteinase and immune function were compared between the two groups. Results: Before treatment, there was no significant difference in the levels of CEA, CA125, CA19-9, MMP-2, MMP-9, CD3+, CD4+, CD8+and CD4+/CD8+between the two groups;After treatment, the levels of CEA, CA125, CA19-9, MMP-2, MMP-9 and CD8+in the two groups were significantly lower than those in the same group before treatment, and the levels of the observation group[(7.79±2.78) ng/mL, (22.56±7.31) U/mL, (13.48±3.05) U/mL, (57.84±8.93) ng/mL, (199.14±67.39) ng/mL and (26.21±4.18)%] were significantly lower than those in the control group;Compared with the group before treatment, the levels of CD3+, CD4+and CD4+/CD8+in the two groups were significantly increased, and the observation group [(66.89±5.84)%, (41.63±5.24)% and (1.37±0.29)] was significantly higher than the control group. Conclusion: S-1 combined with oxaliplatin chemotherapy can effectively reduce serum tumor markers and matrix metalloproteinase levels, improve immune function, has an important clinical value.展开更多
Objective:To observe the clinical effect of combined chemotherapy and Chinese herbal medicine in treating colonic cancer.Methods:One hundred and sixty-three patients were assigned,according to their will,to two groups...Objective:To observe the clinical effect of combined chemotherapy and Chinese herbal medicine in treating colonic cancer.Methods:One hundred and sixty-three patients were assigned,according to their will,to two groups,105 in the traditional Chinese medicine treated group(Group A) and 58 in the combined treatment group(Group B).The Chinese herbal drug Zhao's Weitiao No.3(赵氏微调3号方,ZW3) was given to both groups,twice a day,40 mL each time,30 days as one cycle,and over 6 cycles applied in total.For patients i...展开更多
Chief physician Zhou Lamei performs diagnosis and treatment according to syndrome differentiation,and proposes the method of combining internal treatment with external treatment of traditional Chinese medicine and pay...Chief physician Zhou Lamei performs diagnosis and treatment according to syndrome differentiation,and proposes the method of combining internal treatment with external treatment of traditional Chinese medicine and paying attention to the adjustment of eating habits and lifestyle,which has certain advantages in relieving acute attack,reducing uric acid,reducing gout complications caused by disease development and reducing adverse reactions of western medicine,and is of great significance to the treatment of gout onset and hyperuricemia control.展开更多
The mechanism involved in neural regeneration after spinal cord injury is unclear. The myelin-derived protein Nogo-A, which is specific to the central nervous system, has been identified to negatively affect the cytos...The mechanism involved in neural regeneration after spinal cord injury is unclear. The myelin-derived protein Nogo-A, which is specific to the central nervous system, has been identified to negatively affect the cytoskeleton and growth program of axotomized neurons. Studies have shown that Nogo-A exerts immediate and chronic inhibitory effects on neurite outgrowth. In vivo, inhibitors of Nogo-A have been shown to lead to a marked enhancement of regenerative axon extension. We established a spinal cord injury model in rats using a free-falling weight drop device to subsequently investigate Nogo-A expression. Nogo-A mR NA and protein expression and immunoreactivity were detected in spinal cord tissue using real-time quantitative PCR, immunohistochemistry and western blot analysis. At 24 hours after spinal cord injury, Nogo-A protein and mR NA expression was low in the injured group compared with control and sham-operated groups. The levels then continued to drop further and were at their lowest at 3 days, rapidly rose to a peak after 7 days, and then gradually declined again after 14 days. These changes were observed at both the mR NA and protein level. The transient decrease observed early after injury followed by high levels for a few days indicates Nogo-A expression is time dependent. This may contribute to the lack of regeneration in the central nervous system after spinal cord injury. The dynamic variation of Nogo-A should be taken into account in the treatment of spinal cord injury.展开更多
Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospectiv...Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in China.Patients with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were recruited.The recruited patients were divided into a CM treatment group and a control group according to their wishes.Patients in the CM treatment group received continuous CM therapy for more than 6 months or until disease progression.Patients in the control group received CM therapy for less than 1 month.Follow-up was 8nducted over 3 years.The primary outcome was DFS,with recurrence/metastasis rates as a secondary outcome.Results:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control group.Adjusting for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group patients.Conclusions:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and metastasis.CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China.展开更多
Du Xiaoshan,a chief physician andnative of Wuxi in Jiangsu Province,is famousin acupuncture and moxibustion.He has beenworking as a doctor for over 50 years.Withexquisite medical techniques and rich clinicalexperience...Du Xiaoshan,a chief physician andnative of Wuxi in Jiangsu Province,is famousin acupuncture and moxibustion.He has beenworking as a doctor for over 50 years.Withexquisite medical techniques and rich clinicalexperience,and is good at treating obstinatediseases,often yielding satisfactorytherapeutic results.The author,of this展开更多
OBJECTIVE: To investigate the effects of Shenqi Yangxin decoction(SQYXD) on heart function in a rat model of dilated cardiomyopathy(DCM) and its potential mechanisms.METHODS: Sprague-Dawley rats were randomly divided ...OBJECTIVE: To investigate the effects of Shenqi Yangxin decoction(SQYXD) on heart function in a rat model of dilated cardiomyopathy(DCM) and its potential mechanisms.METHODS: Sprague-Dawley rats were randomly divided into normal(10 rats) and DCM(150 rats)groups. DCM was induced by an intraperitoneal injection of adriamycin. Then, DCM baseline group was randomly selected sixteen DCM rats. The remaining DCM rats were randomly divided into DCM control, perindopril, metoprolol, and SQYXD groups. Cardiac function and histological analysis plus biochemical measurement of serum levels of brain natriuretic peptide(BNP), and inflammatory factors were measured. The mRNA and protein expression levels of high-mobility group box 1(HMGB1), Toll-like receptor 4(TLR-4), receptor for advanced glycation end products(RAGE), and nuclear factor-κB(NF-κB) were determined. Myocardial metabolism imaging was performed on the normal, SQYXD and DCM control groups to evaluate the effectiveness of treatments.RESULTS: Rats in the DCM control group exhibited dilated left ventricular diameter, impaired cardiac function, disorganized sarcomere, impaired glucose metabolism, increased heart weight index,and increased levels of BNP, which were improved by treatment with SQYXD. In addition, hearts from rats in the DCM baseline group exhibited significantly higher levels of HMGB1, TLR-4, RAGE, NF-κB,tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-10, compared with the normal group. Interestingly, the mRNA level of HMGB1 in the DCM baseline group was positively correlated with that of TLR-4, RAGE, NF-κB, BNP, and LVEDD,but negatively correlated with LVEF. SQYXD inhibited the upregulation of HMGB1 expression and its downstream inflammatory factors.CONCLUSION: Shenqi Yangxin decoction effectively reduced the dilated left ventricular diameter and improved heart function in dilated cardiomyopathy. The mechanisms underlying the action on DCM involve regulating the gene and protein expression of HMGB1 and its inflammatory signal pathways in the DCM rat model.展开更多
Objective:To explore the dose-effect relationship of Astragalus granule(AG) on improving the quality of life(QOL) of the patients with chronic heart failure(CHF).Methods:Ninety CHF patients of Fei(肺)-qi deficiency an...Objective:To explore the dose-effect relationship of Astragalus granule(AG) on improving the quality of life(QOL) of the patients with chronic heart failure(CHF).Methods:Ninety CHF patients of Fei(肺)-qi deficiency and/or Xin(心)-Shen(肾) yang-deficiency syndromes were equally randomized divided with a random number table into three groups;they received the high(7.5 g),moderate(4.5 g),and low dosage(2.25 g) of AG orally taken twice a day,respectively,and 4 mg of perindopril tablet once a day for 30 successive days.The heart function grade,patients’ left ventricular ejection fraction(LVEF) and walking distance in 6 min(6mWD) were measured before and after treatment,and the patients’ QOL was scored by the Minnesota Questionnaire for QOL evaluation in the patients with CHF at the same time.Results:The heart function grades of all the three groups after treatment were improved compared with those before treatment,but the improvements in high-dose group and moderate dose group were better than that in the low dose group(P<0.05).LVEFs were increased significantly in all the three groups,but the improvements in the high-dose group(59.42%±7.50%) and moderate dose group(61.98%±6.82%) were better than that in the low dose group(51.45%±6.80%,P<0.01); the 6mWDs in the all groups were also significantly increased(P<0.01),up to 419.80136.23 m,387.15134.13 m, and 317.69±39.97 m,respectively;and Minnesota scores in them were lowered to 29.59±4.69 scores,35.74±5.89 scores,and 42.78±6.06 scores,respectively;comparisons in aspects on 6mWD and Minnesota score showed that the effectiveness with high dose is the most effective,moderate dose as the second,and low dose as the lowest(P<0.01).Conclusions:AG was sufficient to display an optimal effect on improving heart contraction at the moderate dose.In aspects of improving the QOL of CHF patients,the effectiveness of AG showed a dosedependent trend.It should be applied discriminatively depending on the actual condition of patients and the aim of treatment in clinic.展开更多
DU Xiao-shan is a famous physician of traditionalChinese medicine and the initiator of'DU'sAcupuncture'.Based upon his decades' clinicalexperience,Doctor DU simplifies the mountainburningfire method(a ...DU Xiao-shan is a famous physician of traditionalChinese medicine and the initiator of'DU'sAcupuncture'.Based upon his decades' clinicalexperience,Doctor DU simplifies the mountainburningfire method(a needling technique),andapplies it to treat many disorders and obtains excellentresults.We applied this method to 96 cases of facialparalysis and reported it as follows.展开更多
基金the Subject of Wuxi Health and Family Planning Commission(ZXZL201803)Youth Lift Plan of Wuxi Hospital of Traditional Chinese Medicine(ZYY2017B005).
文摘At present,there is a certain understanding of gout combined with diabetes in traditional Chinese medicine,but most studies are related to diabetes combined with hyperuricemia,while few studies are related to gout combined with diabetes.In this paper,the research progress of western medicine in the treatment of gout combined with diabetes is summarized and the research progress of Chinese medicine or integrated Chinese and western medicine in the treatment of gout combined with diabetes is explored.
基金the Subject of Wuxi Health and Family Planning Commission(ZXZL201803)Youth Lift Plan of Wuxi Hospital of Traditional Chinese Medicine(ZYY2017B005).
文摘External application of traditional Chinese medicine has a long history and definite curative effect on gout.By searching the latest literature on the treatment of acute gouty arthritis by external treatment of traditional Chinese medicine,the research progress of external treatment of acute gouty arthritis in recent years was summarized.According to the existing research results,the external treatment of Chinese medicine in the treatment of acute gout has better efficacy and higher safety,and has a broad application prospect.
基金Project of Science and Technology Plan of Tianjin City(Grant number 20ZYJDSY00020)。
文摘Objective:Red blood cell distribution width(RDW)has been utilized as a prognostic indicator for mortality risk assessment in cardiovascular and cerebrovascular patients.Nevertheless,the prognostic significance of RDW in critically ill patients with cerebral infarction is yet to be investigated.The objective of this study is to examine the association between RDW and the risk of all-cause mortality in cerebral infarction patients admitted to the intensive care unit(ICU).Method:A retrospective cohort study was conducted using the Medical Information Mart for Intensive Care IV 2.2(MIMIC-IV)intensive care dataset for data analysis.The main results were the all-cause mortality rates at 3 and 12 months of follow-up.Cumulative curves were plotted using the Kaplan-Meier method,and Cox proportional hazards analysis was used to examine the relationship between RDW and mortality rates in critically ill cerebral infarction patients.Results:The findings indicate that RDW serves as a significant prognostic factor for mortality risk in critically ill stroke patients,specifically at the 3 and 12-month follow-up periods.The observed correlation between increasing RDW levels and higher mortality rates among cerebral infarction patients further supports the potential utility of RDW as a predictive indicator.Conclusion:RDW emerges as an independent predictor of mortality risk during the 3 and 12-month follow-up periods for critically ill patients with cerebral infarction.
基金supported by the National Natural Science Foundation of China,No.81573997the Natural Science Foundation for Colleges and Universities in Jiangsu Province of China,No.15KJD360001the Natural Science Foundation of Jiangsu Province of China,No.BK2011180
文摘The Chinese medicine compound, Jisuikang, can promote recovery of neurological function by inhibiting lipid peroxidation, scavenging oxygen free radicals, and effectively improving the local microenvironment after spinal cord injury. However, the mechanism remains unclear. Thus, we established a rat model of acute spinal cord injury using a modified version of Allen's method. Jisuikang(50, 25, and 12.5 g/kg/d) and prednisolone were administered 30 minutes after anesthesia. Basso, Beattie, and Bresnahan locomotor scale scores and the oblique board test showed improved motor function recovery in the prednisone group and moderate-dose Jisuikang group compared with the other groups at 3–7 days post-injury. The rats in the moderate-dose Jisuikang group recovered best at 14 days post-injury. Hematoxylin-eosin staining and transmission electron microscopy showed that the survival rate of neurons in treatment groups increased after 3–7 days of administration. Further, the structure of neurons and glial cells was more distinct, especially in prednisolone and moderate-dose Jisuikang groups. Western blot assay and immunohistochemistry showed that expression of brain-derived neurotrophic factor(BDNF) in injured segments was maintained at a high level after 7–14 days of treatment. In contrast, expression of nerve growth factor(NGF) was down-regulated at 7 days after spinal cord injury. Real-time fluorescence quantitative polymerase chain reaction showed that expression of BDNF and NGF m RNA was induced in injured segments by prednisolone and Jisuikang. At 3–7 days after injury, the effect of prednisolone was greater, while 14 days after injury, the effect of moderate-dose Jisuikang was greater. These results confirm that Jisuikang can upregulate BDNF and NGF expression for a prolonged period after spinal cord injury and promote repair of acute spinal cord injury, with its effect being similar to prednisolone.
文摘AIM:To evaluate the effects of angiopoietin-1(Ang-1) on adhesion of gastric cancer cell line BGC-823 and expression of integrinβ1,CD44V6,urokinase-type plasminogen activator(uPA)and matrix metalloproteinase-2(MMP-2). METHODS:BGC-823 cells were transfected transiently with adenovirus-Ang-1(Ad-Ang-1).Cells transfected transiently with adenovirus-green fluorescent protein (Ad-GFP)and untransfected cells were used as a negative and blank control group,respectively.The cell adhesion rate between cell and extracellular matrix(ECM)was determined by cell adhesion assay. To investigate whether Ang-1 could reinforce gastric carcinoma metastasis,we performed migration and invasion assays in BGC-823 cells.The mRNA and protein expression of integrinβ1,CD44V6,uPA and MMP-2 were detected by reverse transcription polymerasechain reaction and Western blotting,respectively.The expression of integrinβ1 and CD44V6 was measured by immunohistochemistry. RESULTS:BGC-823 cells were transfected successfully. The adhesion rate increased significantly in the Ad- Ang-1 group(P<0.05).The Ad-Ang-1-transfected group had a significant increase in migration and invasion compared with that of the mock-transfected and Ad-GFP groups.The mRNA and protein expression of integrinβ1,CD44V6,uPA and MMP-2 in the Ad-Ang-1 group was higher than that in the Ad-GFP and blank control groups(P<0.05).Compared with mock- transfected and Ad-GFP groups,integrinβ1 and CD44V6 expression intensity greatly increased(P<0.05). CONCLUSION:Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrinβ1 and CD44V6,by which cell adhesion and metastasis to the ECM are promoted.
基金Supported by Six Peak Talents Projects in Jiangsu Province on Clinical Application of HuRAT1 Combined with ABCG2 Gene Detection in Predicting Hyperuricemia/Gout Susceptibility(2015-WSN-089)Research Projects of Traditional Chinese Medicine of Wuxi Municipal Health Commission on Mechanisms of Bixie Drink on Neutrophils and Inflammatory Signal Transduction Pathway of NLRP3 in Gout Model Rats(ZYZL201803).
文摘Gout is an independent risk factor for hypertension,diabetes mellitus,hyperlipidemia,coronary heart disease and cerebral infarction.At present,the studies on the mechanism of gout at home and abroad have mainly focused on immune inflammation,gene polymorphism and related studies.Uric acid deposition or crystal precipitation activates phagocytes,fibroblasts and mast cells in synovium,produces IL-1β,TNF and chemokine IL-8(CXCL8),thereby activating neutrophils,urate crystal polyanion surface can be coated with immunoglobulins and other serum proteins as substrates for complement activation,complement substitution pathways and classical complement pathways to activate complements.Uric acid crystals activate inflammation-related signal transduction pathways including the activation of inflammation-related signal transduction pathway by uric acid crystals and TLRS/MyD88 signal transduction pathways.Gene polymorphism is related to inflammation and signaling pathway,EGF gene is closely related to gout inflammation,which may be involved in the regulation of gout inflammation,among which NLRP3 inflammatory signaling pathway and gene polymorphism have been deeply studied in the pathogenesis of gout,which is the main therapeutic target of anti-inflammatory and uric acid lowering.
基金Supported by"Project of Strengthening Health through Science and Education"of Wuxi Health Commission:The Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘More than 40 medical history and classical medical literature on the nomenclature of Bi syndrome were systematically arranged,induced and analyzed,the prescriptions named after the medicine include RHIZOMA ET RADIX NOTOPTERYGII,os tigris,RADIX ASTRAGALI,RADIX SAPOSHNIKOVIAE,Prepared common monkshood daughter root,doubleteeth pubescent angelica root,RADIX ANGELICAE SINENSIS,frankincense,RADIX STEPHANIAE TETRANDRAE,RADIX ACHYRANTHIS BIDENTATAE,myrrh,RADIX ACONITI、RADIX DIPSACI,RHIZOMA GASTRODIAE,ginseng root,HERBA DENDROBII,CORNU SAIGAE TATARICAE,RADIX MORINDAE OFFICINALIS,PORIA,SEMEN COICIS,poison yam,and so on.It basically reflected the ancient and modern treatment of Bi syndrome in traditional Chinese medicine named after the formula.
基金"Project of Strengthening Health through Science and Education"of Wuxi Health Commission—Study on the Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘More than 30 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome from Zang and Fu were collected,summarized and analyzed,and the theory of treating arthralgia syndrome from Zang and Fu in the lung,spleen,liver and kidney basically reflected the academic thought of treating Bi syndrome from the viscera in traditional Chinese medicine books.
基金Supported by"Project of Strengthening Health through Science and Education"of Wuxi Health Commission:Study on the Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘The literatures in more than 40 medical history books and classical medical works about TCM name and classification of Bi syndrome were systematically sorted out,summarized and analyzed,which basically reflected the academic origin of Bi syndrome in ancient and modern Chinese medicine.Through the research on the academic origin of the nomenclature of arthralgia syndrome in traditional Chinese medicine,the changes of the nomenclature of arthralgia syndrome in traditional Chinese medicine were clearly grasped,which was of great significance for the further standardization of the nomenclature of arthralgia syndrome.
基金"Project of Strengthening Health through Science and Education"of Wuxi Health Commission:Study on the Effect of Huli Powder on Anti-inflammation and Bone Metabolism of Hand Osteoarthritis(2016,No.ZDRCPY013)Study on the Key Technology of"Yiqi Tongluo"Therapy of Wumen for Osteoarthritis(SS201876).
文摘More than 40 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome treated from eliminating pathogen and strengthening vital qi were sorted out,summarized and analyzed,and the theory of treating arthralgia syndrome from eliminating pathogenic factors including dampness,heat,cold,phlegm and blood stasis,and strengthening vital qi basically reflected the academic thought of treating Bi syndrome from eliminating pathogen and strengthening vital qi in traditional Chinese medicine books.
基金Optimization of TCM Treatment Based on Rheumatoid Arthritis Epidemiology Database(ZYYZD21004)Exploration of the Mechanism of Wumen’s"Nourishing Yin,Clearing Heat and Dredging Collaterals"in the Treatment of Rheumatoid Arthritis Based on Th17/Treg Cell Balance(GSWS2020086)。
文摘Rheumatoid arthritis(RA)belongs to the category of"bi syndrome(arthralgia syndrome)"in traditional Chinese medicine(TCM).According to the characteristics of clinical symptoms,there are descriptions of"bone bi(bone arthralgia)","arthroncus of knee"and"drumstick wind"in TCM.Modern physicians have studied the etiology,pathogenesis and treatment of RA from the treatment of the viscera,including the treatment from the spleen,liver and kidney,treatment from ying(nutrient)and wei(defense),and treatment from ethnic medicine by drawing on the theories of ancient physicians and clinical experience.
文摘Objective: To investigate the effect of Compound Tegafur and Oteracil Potassium Sustained Capsules (S-1) combined with oxaliplatin chemotherapy on serum tumor marker matrix metalloproteinase and immune function in elderly patients with gastric cancer. Methods:According to the random data table, 80 cases of elderly patients with gastric cancer were divided into control group and observation group (n=40), patients in the control group were treated with oxaliplatin combined with Capecitabine Tablets, and the observation group patients were treated with S-1 combined with oxaliplatin, all treated for 6 cycles, before and after treatment, levels of serum tumor markers, matrix metalloproteinase and immune function were compared between the two groups. Results: Before treatment, there was no significant difference in the levels of CEA, CA125, CA19-9, MMP-2, MMP-9, CD3+, CD4+, CD8+and CD4+/CD8+between the two groups;After treatment, the levels of CEA, CA125, CA19-9, MMP-2, MMP-9 and CD8+in the two groups were significantly lower than those in the same group before treatment, and the levels of the observation group[(7.79±2.78) ng/mL, (22.56±7.31) U/mL, (13.48±3.05) U/mL, (57.84±8.93) ng/mL, (199.14±67.39) ng/mL and (26.21±4.18)%] were significantly lower than those in the control group;Compared with the group before treatment, the levels of CD3+, CD4+and CD4+/CD8+in the two groups were significantly increased, and the observation group [(66.89±5.84)%, (41.63±5.24)% and (1.37±0.29)] was significantly higher than the control group. Conclusion: S-1 combined with oxaliplatin chemotherapy can effectively reduce serum tumor markers and matrix metalloproteinase levels, improve immune function, has an important clinical value.
基金Supported by 2005 Social Developing Scientific and Technological Guidance Program of Jiangsu Province(No.BS2005613)
文摘Objective:To observe the clinical effect of combined chemotherapy and Chinese herbal medicine in treating colonic cancer.Methods:One hundred and sixty-three patients were assigned,according to their will,to two groups,105 in the traditional Chinese medicine treated group(Group A) and 58 in the combined treatment group(Group B).The Chinese herbal drug Zhao's Weitiao No.3(赵氏微调3号方,ZW3) was given to both groups,twice a day,40 mL each time,30 days as one cycle,and over 6 cycles applied in total.For patients i...
文摘Chief physician Zhou Lamei performs diagnosis and treatment according to syndrome differentiation,and proposes the method of combining internal treatment with external treatment of traditional Chinese medicine and paying attention to the adjustment of eating habits and lifestyle,which has certain advantages in relieving acute attack,reducing uric acid,reducing gout complications caused by disease development and reducing adverse reactions of western medicine,and is of great significance to the treatment of gout onset and hyperuricemia control.
基金financially supported by a grant from the Natural Science Foundation of Jiangsu Province,No.BK2011180Ordinary University Graduate Student Scientific Research Innovation Projects of Jiangsu Province,No.CXZZ13-0614,CXZZ12-0609
文摘The mechanism involved in neural regeneration after spinal cord injury is unclear. The myelin-derived protein Nogo-A, which is specific to the central nervous system, has been identified to negatively affect the cytoskeleton and growth program of axotomized neurons. Studies have shown that Nogo-A exerts immediate and chronic inhibitory effects on neurite outgrowth. In vivo, inhibitors of Nogo-A have been shown to lead to a marked enhancement of regenerative axon extension. We established a spinal cord injury model in rats using a free-falling weight drop device to subsequently investigate Nogo-A expression. Nogo-A mR NA and protein expression and immunoreactivity were detected in spinal cord tissue using real-time quantitative PCR, immunohistochemistry and western blot analysis. At 24 hours after spinal cord injury, Nogo-A protein and mR NA expression was low in the injured group compared with control and sham-operated groups. The levels then continued to drop further and were at their lowest at 3 days, rapidly rose to a peak after 7 days, and then gradually declined again after 14 days. These changes were observed at both the mR NA and protein level. The transient decrease observed early after injury followed by high levels for a few days indicates Nogo-A expression is time dependent. This may contribute to the lack of regeneration in the central nervous system after spinal cord injury. The dynamic variation of Nogo-A should be taken into account in the treatment of spinal cord injury.
基金Supported by Special Funded Projects of the TCM Industry(No.201307006)National Natural Science Foundation of China(No.81473467)Beijing Natural Science Fund(No.7192181)
文摘Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in China.Patients with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were recruited.The recruited patients were divided into a CM treatment group and a control group according to their wishes.Patients in the CM treatment group received continuous CM therapy for more than 6 months or until disease progression.Patients in the control group received CM therapy for less than 1 month.Follow-up was 8nducted over 3 years.The primary outcome was DFS,with recurrence/metastasis rates as a secondary outcome.Results:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control group.Adjusting for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group patients.Conclusions:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and metastasis.CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China.
文摘Du Xiaoshan,a chief physician andnative of Wuxi in Jiangsu Province,is famousin acupuncture and moxibustion.He has beenworking as a doctor for over 50 years.Withexquisite medical techniques and rich clinicalexperience,and is good at treating obstinatediseases,often yielding satisfactorytherapeutic results.The author,of this
基金Supported by the Projects of Medical Technology of Management Center of Wuxi Hospital,Jiangsu Province(No.YGZXM14047:Application of Standardized Diagnosis and Treatment Scheme for Dilated Cardiomyopathy Combined with Staging)the Projects of Jiangsu Province Chinese Medicine Leading Personnel Training Target Fund(Treatment of Dilated Cardiomyopathy with Classic Compound)
文摘OBJECTIVE: To investigate the effects of Shenqi Yangxin decoction(SQYXD) on heart function in a rat model of dilated cardiomyopathy(DCM) and its potential mechanisms.METHODS: Sprague-Dawley rats were randomly divided into normal(10 rats) and DCM(150 rats)groups. DCM was induced by an intraperitoneal injection of adriamycin. Then, DCM baseline group was randomly selected sixteen DCM rats. The remaining DCM rats were randomly divided into DCM control, perindopril, metoprolol, and SQYXD groups. Cardiac function and histological analysis plus biochemical measurement of serum levels of brain natriuretic peptide(BNP), and inflammatory factors were measured. The mRNA and protein expression levels of high-mobility group box 1(HMGB1), Toll-like receptor 4(TLR-4), receptor for advanced glycation end products(RAGE), and nuclear factor-κB(NF-κB) were determined. Myocardial metabolism imaging was performed on the normal, SQYXD and DCM control groups to evaluate the effectiveness of treatments.RESULTS: Rats in the DCM control group exhibited dilated left ventricular diameter, impaired cardiac function, disorganized sarcomere, impaired glucose metabolism, increased heart weight index,and increased levels of BNP, which were improved by treatment with SQYXD. In addition, hearts from rats in the DCM baseline group exhibited significantly higher levels of HMGB1, TLR-4, RAGE, NF-κB,tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-10, compared with the normal group. Interestingly, the mRNA level of HMGB1 in the DCM baseline group was positively correlated with that of TLR-4, RAGE, NF-κB, BNP, and LVEDD,but negatively correlated with LVEF. SQYXD inhibited the upregulation of HMGB1 expression and its downstream inflammatory factors.CONCLUSION: Shenqi Yangxin decoction effectively reduced the dilated left ventricular diameter and improved heart function in dilated cardiomyopathy. The mechanisms underlying the action on DCM involve regulating the gene and protein expression of HMGB1 and its inflammatory signal pathways in the DCM rat model.
基金Supported by the Funds of Scientific and Technological Research on Traditional Chinese Medicine,Traditional Chinese Medicine Administration of Jiangsu Province,China(No. HL07113)
文摘Objective:To explore the dose-effect relationship of Astragalus granule(AG) on improving the quality of life(QOL) of the patients with chronic heart failure(CHF).Methods:Ninety CHF patients of Fei(肺)-qi deficiency and/or Xin(心)-Shen(肾) yang-deficiency syndromes were equally randomized divided with a random number table into three groups;they received the high(7.5 g),moderate(4.5 g),and low dosage(2.25 g) of AG orally taken twice a day,respectively,and 4 mg of perindopril tablet once a day for 30 successive days.The heart function grade,patients’ left ventricular ejection fraction(LVEF) and walking distance in 6 min(6mWD) were measured before and after treatment,and the patients’ QOL was scored by the Minnesota Questionnaire for QOL evaluation in the patients with CHF at the same time.Results:The heart function grades of all the three groups after treatment were improved compared with those before treatment,but the improvements in high-dose group and moderate dose group were better than that in the low dose group(P<0.05).LVEFs were increased significantly in all the three groups,but the improvements in the high-dose group(59.42%±7.50%) and moderate dose group(61.98%±6.82%) were better than that in the low dose group(51.45%±6.80%,P<0.01); the 6mWDs in the all groups were also significantly increased(P<0.01),up to 419.80136.23 m,387.15134.13 m, and 317.69±39.97 m,respectively;and Minnesota scores in them were lowered to 29.59±4.69 scores,35.74±5.89 scores,and 42.78±6.06 scores,respectively;comparisons in aspects on 6mWD and Minnesota score showed that the effectiveness with high dose is the most effective,moderate dose as the second,and low dose as the lowest(P<0.01).Conclusions:AG was sufficient to display an optimal effect on improving heart contraction at the moderate dose.In aspects of improving the QOL of CHF patients,the effectiveness of AG showed a dosedependent trend.It should be applied discriminatively depending on the actual condition of patients and the aim of treatment in clinic.
文摘DU Xiao-shan is a famous physician of traditionalChinese medicine and the initiator of'DU'sAcupuncture'.Based upon his decades' clinicalexperience,Doctor DU simplifies the mountainburningfire method(a needling technique),andapplies it to treat many disorders and obtains excellentresults.We applied this method to 96 cases of facialparalysis and reported it as follows.
