This work presents an optimal design method of antenna aperture illumination for microwave power transmission with an annular collection area.The objective is to maximize the ratio of the power radiated on the annular...This work presents an optimal design method of antenna aperture illumination for microwave power transmission with an annular collection area.The objective is to maximize the ratio of the power radiated on the annular collection area to the total transmitted power.By formulating the aperture amplitude distribution through a summation of a special set of series,the optimal design problem can be reduced to finding the maximum ratio of two real quadratic forms.Based on the theory of matrices,the solution to the formulated optimization problem is to determine the largest characteristic value and its associated characteristic vector.To meet security requirements,the peak radiation levels outside the receiving area are considered to be extra constraints.A hybrid grey wolf optimizer and Nelder–Mead simplex method is developed to deal with this constrained optimization problem.In order to demonstrate the effectiveness of the proposed method,numerical experiments on continuous apertures are conducted;then,discrete arrays of isotropic elements are employed to validate the correctness of the optimized results.Finally,patch arrays are adopted to further verify the validity of the proposed method.展开更多
The essential role of immunoglobulin G(IgG)in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine ...The essential role of immunoglobulin G(IgG)in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the fragment crystallizable(Fc)domain that occur under such circumstances.These glycans impact the antibody stability,half-life,secretion,immunogenicity,and effector functions.Therefore,in this study,we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits(sialylation,galactosylation,fucosylation,and bisecting Nacetylglucosamine(GlcNAc))—of 64 patients with influenza,77 patients with coronavirus disease 2019(COVID-19),and 56 healthy controls.Our study revealed a significant decrease in IgG galactosylation,sialylation,and bisecting GlcNAc(where the latter shows the most significant decrease)in deceased COVID19 patients,whereas IgG fucosylation was increased.On the other hand,IgG galactosylation remained stable in influenza patients and COVID-19 survivors.IgG glycosylation in influenza patients was more time-dependent:In the first seven days of the disease,sialylation increased and fucosylation and bisecting GlcNAc decreased;in the next 21 days,sialylation decreased and fucosylation increased(while bisecting GlcNAc remained stable).The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses,while the observed changes in deceased COVID-19 patients may indicate its deviation.展开更多
This paper reports on analysis of an expermental study that armed to determine the apparent gas permeability in cracked concrete.There is a lack of research on this topic in the international literature,due to the dif...This paper reports on analysis of an expermental study that armed to determine the apparent gas permeability in cracked concrete.There is a lack of research on this topic in the international literature,due to the difficulty of performing reliable experimental testing for gas permeability.The principal interest of this work is to present new and reliable experimental results.Analytical functions between the evolution of the apparent crack permeability and the apparent crack opening are also proposed.These functions appear to be relevant in consideration of Poiseuille theory.展开更多
In modern wireless communication systems,the signal-to-noise ratio(SNR)is one of the most important performance indicators.When the other radio frequency(RF)performance of the components is well designed,passive inter...In modern wireless communication systems,the signal-to-noise ratio(SNR)is one of the most important performance indicators.When the other radio frequency(RF)performance of the components is well designed,passive intermodulation(PIM)interference may become an important factor limiting the system’s SNR.Whether it is a base station,an indoor distributed antenna system,or a satellite system,there are stringent PIM level requirements to minimize interference and enhance network capacity in multicarrier networks.Especially for systems of high power and wide bandwidth such as 5G wireless communication,PIM interference is even more serious.Due to the complexity and uncertainty of PIM,measurement is the most important means to study and evaluate the PIM performance of wireless communication systems.In this review,the current main PIM measurement methods recommended by International Electrotechnical Commission(IEC)and other standard organizations are introduced,and several key challenges in PIM measurement and their solutions(including the design of PIM tester,the location of the PIM sources,the design of compact PIM anechoic chambers,and the evaluation methods of PIM anechoic chambers)are highlighted.These challenges are of great significance to solve PIM problems that may arise during device characterization and verification in real wireless communication systems.展开更多
Fresh fruits are highly valued by consumers worldwide,owing to their delicious flavors,abundant nutrients,and health-promoting characteristics,and as such,fruits make up an important component of a healthy diet.The po...Fresh fruits are highly valued by consumers worldwide,owing to their delicious flavors,abundant nutrients,and health-promoting characteristics,and as such,fruits make up an important component of a healthy diet.The postharvest quality and safety of fresh fruit involve complex interactions among the fruit,environmental factors,and postharvest pathogens.Efficient regulation of fruit senescence and pathogen resistance,as well as disease-causing abilities of postharvest pathogens,is critical to understanding the fundamental mechanisms that underlie fruit quality and safety.This paper provides a comprehensive review of recent advances and currently available strategies for maintaining fruit quality and controlling major postharvest pathogens,mainly Botrytis cinerea and Penicillium expansum,which may promote sustainable and environmental-friendly development of the fruit industry.展开更多
In November 2020,BWX Technologies,based in Lynchburg,VA,USA,announced it had once again begun manufacturing a nuclear fuel known as tristructural isoptropic(TRISO)particles[1].The company,which is designing a mobile r...In November 2020,BWX Technologies,based in Lynchburg,VA,USA,announced it had once again begun manufacturing a nuclear fuel known as tristructural isoptropic(TRISO)particles[1].The company,which is designing a mobile reactor that will run on the fuel[2],is not the only nuclear firm that is betting on the future of TRISO.At least three other US companies have incorporated it into their advanced reactor designs[3,4].展开更多
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage dis...Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.展开更多
Microseismic(MS)event locations are vital aspect of MS monitoring technology used to delineate the damage zone inside the surrounding rock mass.However,complex geological conditions can impose significantly adverse ef...Microseismic(MS)event locations are vital aspect of MS monitoring technology used to delineate the damage zone inside the surrounding rock mass.However,complex geological conditions can impose significantly adverse effects on the final location results.To achieve a high-accuracy location in a complex cavern-containing structure,this study develops an MS location method using the fast marching method(FMM)with a second-order difference approach(FMM2).Based on the established velocity model with three-dimensional(3D)discrete grids,the realization of the MS location can be achieved by searching the minimum residual between the theoretical and actual first arrival times.Moreover,based on the calculation results of FMM2,the propagation paths from the MS sources to MS sensors can be obtained using the linear interpolation approach and the Runge–Kutta method.These methods were validated through a series of numerical experiments.In addition,our proposed method was applied to locate the recorded blasting and MS events that occurred during the excavation period of the underground caverns at the Houziyan hydropower station.The location results of the blasting activities show that our method can effectively reduce the location error compared with the results based on the uniform velocity model.Furthermore,the obtained MS location was verified through the occurrence of shotcrete fractures and spalling,and the monitoring results of the in-situ multipoint extensometer.Our proposed method can offer a more accurate rock fracture location and facilitate the delineation of damage zones inside the surrounding rock mass.展开更多
Early detection of hepatocellular carcinoma(HCC)while in its early stages is critical for reducing HCC mortality in high-risk patients.However,highly sensitive and specific surveillance biomarkers for early-stage HCC ...Early detection of hepatocellular carcinoma(HCC)while in its early stages is critical for reducing HCC mortality in high-risk patients.However,highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still lacking.In recent years,great efforts have been made to research tumor-derived molecular features that are detectable in circulation,such as circulating tumor deoxyribonucleic acid and circulating tumor ribonucleic acid,in order to explore their potential as noninvasive biomarker candidates in many tumor types.In this review,we summarize current studies on these new approaches and their application in early HCC detection.展开更多
Using the FengYun-3C(FY-3C)onboard BeiDou Navigation Satellite System(BDS)and Global Positioning System(GPS)data from 2013 to 2017,this study investigates the performance and contribution of BDS to precise orbit deter...Using the FengYun-3C(FY-3C)onboard BeiDou Navigation Satellite System(BDS)and Global Positioning System(GPS)data from 2013 to 2017,this study investigates the performance and contribution of BDS to precise orbit determination(POD)for a low-Earth orbit(LEO).The overlap comparison result indicates that code bias correction of BDS can improve the POD accuracy by 12.4%.The multi-year averaged one-dimensional(1D)root mean square(RMS)of the overlapping orbit differences(OODs)for the GPS-only solution is 2.0,1.7,and 1.5 cm,respectively,during the 2013,2015,and 2017 periods.The 1D RMS for the BDS-only solution is 150.9,115.0,and 47.4 cm,respectively,during the 2013,2015,and 2017 periods,which is much worse than the GPS-only solution due to the regional system of BDS and the few BDS channels of the FY-3C receiver.For the BDS and GPS combined solution(also known as the GC combined solution),the averaged 1D RMS is 2.5,2.3,and 1.6 cm,respectively,in 2013,2015,and 2017,while the GC combined POD presents a significant accuracy improvement after the exclusion of geostationary Earth orbit(GEO)satellites.The main reason for the improvement seen after this exclusion is the unfavorable satellite tracking geometry and poor orbit accuracy of GEO satellites.The accuracy of BDS-only and GC combined solutions have gradually improved from 2013 to 2017,thanks to improvements in the accuracy of International GNSS Service(IGS)orbit and clock products in recent years,especially the availability of a high-frequency satellite clock product(30 s sampling interval)since 2015.Moreover,the GC POD(without GEO)was able to achieve slightly better accuracy than the GPS-only POD in 2017,indicating that the fusion of BDS and GPS observations can improve the accuracy of LEO POD.GC combined POD can significantly improve the reliability of LEO POD,simply due to system redundancy.An increased contribution of BDS to LEO POD can be expected with the launch of more BDS satellites and with further improvements in the accuracy of BDS satellite products in the near future.展开更多
Volatile elements—such as carbon, hydrogen, sulfur, nitrogen, and halogens—are minor constituents of Earth’s deep interior. Despite their low abundances, deep volatiles mediate major Earth processes, including magm...Volatile elements—such as carbon, hydrogen, sulfur, nitrogen, and halogens—are minor constituents of Earth’s deep interior. Despite their low abundances, deep volatiles mediate major Earth processes, including magma generation, volcanism, mantle convection, and plate tectonics, which control the exchange of volatiles between Earth’s deep interior and its surface. Over geological time, deep volatiles play critical, primary roles in governing energy resources, natural hazards, atmospheric composition, climate, and planetary habitability. Human activities after the industrial revolution have played an impactful, secondary role, and the resulting risk of add-on effects that could lead to irreversible runaway catastrophes has greatly increased.展开更多
Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike ...Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike chemical compounds and proteins, cells are living, self-replicating drugs that can be engineered to possess exquisite specificity. For example, T cells can be genetically modified to express chimeric antigen receptors (CARs), endowing them with the capacity to recognize and kill tumor cells and form a memory pool that is ready to strike back against persisting malignant cells. Anti-CD19 chimeric antigen receptor T cells (CART19s) have demonstrated a remarkable degree of clinical efficacy for certain malignancies. The process of developing CART19 essentially follows the conventional “one gene, one drug, one disease” paradigm derived from Paul Ehrlich’s “magic bullet” concept. With major players within the pharmaceutical industry joining forces to commercialize this new category of “living drugs,” it is useful to use CART19 as an example to examine the similarities and differences in its development, compared with that of a conventional drug. In this way, we can assimilate existing knowledge and identify the most effective approach for advancing similar strategies. This article reviews the use of biomarker-based assays to guide the optimization of CAR constructs, preclinical studies, and the evaluation of clinical efficacy;adverse effects (AEs);and CART19 cellular kinetics. Advanced technologies and computational tools that enable the discovery of optimal targets, novel CAR binding domains, and biomarkers predicting clinical response and AEs are also discussed. We believe that the success of CART19 will lead to the development of other engineered T cell therapies in the same manner that the discovery of arsphenamine initiated the era of synthetic pharmaceuticals.展开更多
The world’s longest and deepest tunnel,the 57.1 km long Gotthard Base Tunnel,was officially opened on June 1,2016 after 20years of effort[1,2],as shown in Fig.1[3,4].The tunnel,actually twin tubes,under the Gotthard ...The world’s longest and deepest tunnel,the 57.1 km long Gotthard Base Tunnel,was officially opened on June 1,2016 after 20years of effort[1,2],as shown in Fig.1[3,4].The tunnel,actually twin tubes,under the Gotthard Massif of the Swiss Alps connects Erstfeld in the north to Bodio in the south,effectively connecting northern and southern Europe with a high speed-high展开更多
Functional crystals are the basic materials for the development of modern science and technology and are playing key roles in the modern information era. In this paper, we review functional crystals in China, includin...Functional crystals are the basic materials for the development of modern science and technology and are playing key roles in the modern information era. In this paper, we review functional crystals in China, including research history, significant achievements, and important applications by highlighting the most recent progress in research. Challenges for the development of functional materials are discussed and possible directions for development are proposed by focusing on potential strengths of these materials.展开更多
基金supported in part by the National Key Research and Development Program of China(2021YFB3900300)in part by the National Natural Science Foundation of China(62201416)+2 种基金in part by the Fundamental Research Funds for the Central Universities(QTZX23070)in part by the Qin Chuang Yuan High-Level Innovative and Entrepreneurial Talents Project(QCYRCXM-2022-314)in part by Singapore Ministry of Education Academic Research Fund Tier 1。
文摘This work presents an optimal design method of antenna aperture illumination for microwave power transmission with an annular collection area.The objective is to maximize the ratio of the power radiated on the annular collection area to the total transmitted power.By formulating the aperture amplitude distribution through a summation of a special set of series,the optimal design problem can be reduced to finding the maximum ratio of two real quadratic forms.Based on the theory of matrices,the solution to the formulated optimization problem is to determine the largest characteristic value and its associated characteristic vector.To meet security requirements,the peak radiation levels outside the receiving area are considered to be extra constraints.A hybrid grey wolf optimizer and Nelder–Mead simplex method is developed to deal with this constrained optimization problem.In order to demonstrate the effectiveness of the proposed method,numerical experiments on continuous apertures are conducted;then,discrete arrays of isotropic elements are employed to validate the correctness of the optimized results.Finally,patch arrays are adopted to further verify the validity of the proposed method.
基金supported by the European Structural and Investment Funds grant for the Croatian National Centre of Competence in Molecular Diagnostics (KK.01.2.2.03.0006)the Croatian National Centre of Research Excellence in Personalized Healthcare grant (KK.01.1.1.01.0010)supported by the Human Glycome Project。
文摘The essential role of immunoglobulin G(IgG)in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the fragment crystallizable(Fc)domain that occur under such circumstances.These glycans impact the antibody stability,half-life,secretion,immunogenicity,and effector functions.Therefore,in this study,we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits(sialylation,galactosylation,fucosylation,and bisecting Nacetylglucosamine(GlcNAc))—of 64 patients with influenza,77 patients with coronavirus disease 2019(COVID-19),and 56 healthy controls.Our study revealed a significant decrease in IgG galactosylation,sialylation,and bisecting GlcNAc(where the latter shows the most significant decrease)in deceased COVID19 patients,whereas IgG fucosylation was increased.On the other hand,IgG galactosylation remained stable in influenza patients and COVID-19 survivors.IgG glycosylation in influenza patients was more time-dependent:In the first seven days of the disease,sialylation increased and fucosylation and bisecting GlcNAc decreased;in the next 21 days,sialylation decreased and fucosylation increased(while bisecting GlcNAc remained stable).The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses,while the observed changes in deceased COVID-19 patients may indicate its deviation.
基金funding support from French National Research Agency through the MACENA project(ANR-11-RSNR-012)。
文摘This paper reports on analysis of an expermental study that armed to determine the apparent gas permeability in cracked concrete.There is a lack of research on this topic in the international literature,due to the difficulty of performing reliable experimental testing for gas permeability.The principal interest of this work is to present new and reliable experimental results.Analytical functions between the evolution of the apparent crack permeability and the apparent crack opening are also proposed.These functions appear to be relevant in consideration of Poiseuille theory.
文摘In modern wireless communication systems,the signal-to-noise ratio(SNR)is one of the most important performance indicators.When the other radio frequency(RF)performance of the components is well designed,passive intermodulation(PIM)interference may become an important factor limiting the system’s SNR.Whether it is a base station,an indoor distributed antenna system,or a satellite system,there are stringent PIM level requirements to minimize interference and enhance network capacity in multicarrier networks.Especially for systems of high power and wide bandwidth such as 5G wireless communication,PIM interference is even more serious.Due to the complexity and uncertainty of PIM,measurement is the most important means to study and evaluate the PIM performance of wireless communication systems.In this review,the current main PIM measurement methods recommended by International Electrotechnical Commission(IEC)and other standard organizations are introduced,and several key challenges in PIM measurement and their solutions(including the design of PIM tester,the location of the PIM sources,the design of compact PIM anechoic chambers,and the evaluation methods of PIM anechoic chambers)are highlighted.These challenges are of great significance to solve PIM problems that may arise during device characterization and verification in real wireless communication systems.
基金This study was supported by project funding from the National Natural Science Foundation of China(31530057,31930086,31672210,31722043,and 31671910).
文摘Fresh fruits are highly valued by consumers worldwide,owing to their delicious flavors,abundant nutrients,and health-promoting characteristics,and as such,fruits make up an important component of a healthy diet.The postharvest quality and safety of fresh fruit involve complex interactions among the fruit,environmental factors,and postharvest pathogens.Efficient regulation of fruit senescence and pathogen resistance,as well as disease-causing abilities of postharvest pathogens,is critical to understanding the fundamental mechanisms that underlie fruit quality and safety.This paper provides a comprehensive review of recent advances and currently available strategies for maintaining fruit quality and controlling major postharvest pathogens,mainly Botrytis cinerea and Penicillium expansum,which may promote sustainable and environmental-friendly development of the fruit industry.
文摘In November 2020,BWX Technologies,based in Lynchburg,VA,USA,announced it had once again begun manufacturing a nuclear fuel known as tristructural isoptropic(TRISO)particles[1].The company,which is designing a mobile reactor that will run on the fuel[2],is not the only nuclear firm that is betting on the future of TRISO.At least three other US companies have incorporated it into their advanced reactor designs[3,4].
基金This work was supported by grants from the National Sciences Fund(31370938 and 81272528)The Fund(81272528)offered experiment material and collected the data for analysisThe Fund(31370938)helped design the study and was helpful in preparing the manuscript.
文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.
基金the Key Program of National Natural Science Foundation of China(52039007)for providing financial support.
文摘Microseismic(MS)event locations are vital aspect of MS monitoring technology used to delineate the damage zone inside the surrounding rock mass.However,complex geological conditions can impose significantly adverse effects on the final location results.To achieve a high-accuracy location in a complex cavern-containing structure,this study develops an MS location method using the fast marching method(FMM)with a second-order difference approach(FMM2).Based on the established velocity model with three-dimensional(3D)discrete grids,the realization of the MS location can be achieved by searching the minimum residual between the theoretical and actual first arrival times.Moreover,based on the calculation results of FMM2,the propagation paths from the MS sources to MS sensors can be obtained using the linear interpolation approach and the Runge–Kutta method.These methods were validated through a series of numerical experiments.In addition,our proposed method was applied to locate the recorded blasting and MS events that occurred during the excavation period of the underground caverns at the Houziyan hydropower station.The location results of the blasting activities show that our method can effectively reduce the location error compared with the results based on the uniform velocity model.Furthermore,the obtained MS location was verified through the occurrence of shotcrete fractures and spalling,and the monitoring results of the in-situ multipoint extensometer.Our proposed method can offer a more accurate rock fracture location and facilitate the delineation of damage zones inside the surrounding rock mass.
文摘Early detection of hepatocellular carcinoma(HCC)while in its early stages is critical for reducing HCC mortality in high-risk patients.However,highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still lacking.In recent years,great efforts have been made to research tumor-derived molecular features that are detectable in circulation,such as circulating tumor deoxyribonucleic acid and circulating tumor ribonucleic acid,in order to explore their potential as noninvasive biomarker candidates in many tumor types.In this review,we summarize current studies on these new approaches and their application in early HCC detection.
基金We are very grateful to the IGS,GFZ,and WHU for providing the precise orbit and clock products of GPS and BDS.Thanks also go to the EPOS-RT/PANDA software from GFZ.This study is financially supported by the National Natural Science Foundation of China(41774030,41974027,41974029,and 41505030)the Hubei Province Natural Science Foundation of China(2018CFA081)The numerical calculations in this paper were done on the supercomputing system at the Supercomputing Center of Wuhan University.
文摘Using the FengYun-3C(FY-3C)onboard BeiDou Navigation Satellite System(BDS)and Global Positioning System(GPS)data from 2013 to 2017,this study investigates the performance and contribution of BDS to precise orbit determination(POD)for a low-Earth orbit(LEO).The overlap comparison result indicates that code bias correction of BDS can improve the POD accuracy by 12.4%.The multi-year averaged one-dimensional(1D)root mean square(RMS)of the overlapping orbit differences(OODs)for the GPS-only solution is 2.0,1.7,and 1.5 cm,respectively,during the 2013,2015,and 2017 periods.The 1D RMS for the BDS-only solution is 150.9,115.0,and 47.4 cm,respectively,during the 2013,2015,and 2017 periods,which is much worse than the GPS-only solution due to the regional system of BDS and the few BDS channels of the FY-3C receiver.For the BDS and GPS combined solution(also known as the GC combined solution),the averaged 1D RMS is 2.5,2.3,and 1.6 cm,respectively,in 2013,2015,and 2017,while the GC combined POD presents a significant accuracy improvement after the exclusion of geostationary Earth orbit(GEO)satellites.The main reason for the improvement seen after this exclusion is the unfavorable satellite tracking geometry and poor orbit accuracy of GEO satellites.The accuracy of BDS-only and GC combined solutions have gradually improved from 2013 to 2017,thanks to improvements in the accuracy of International GNSS Service(IGS)orbit and clock products in recent years,especially the availability of a high-frequency satellite clock product(30 s sampling interval)since 2015.Moreover,the GC POD(without GEO)was able to achieve slightly better accuracy than the GPS-only POD in 2017,indicating that the fusion of BDS and GPS observations can improve the accuracy of LEO POD.GC combined POD can significantly improve the reliability of LEO POD,simply due to system redundancy.An increased contribution of BDS to LEO POD can be expected with the launch of more BDS satellites and with further improvements in the accuracy of BDS satellite products in the near future.
文摘Volatile elements—such as carbon, hydrogen, sulfur, nitrogen, and halogens—are minor constituents of Earth’s deep interior. Despite their low abundances, deep volatiles mediate major Earth processes, including magma generation, volcanism, mantle convection, and plate tectonics, which control the exchange of volatiles between Earth’s deep interior and its surface. Over geological time, deep volatiles play critical, primary roles in governing energy resources, natural hazards, atmospheric composition, climate, and planetary habitability. Human activities after the industrial revolution have played an impactful, secondary role, and the resulting risk of add-on effects that could lead to irreversible runaway catastrophes has greatly increased.
基金support from the Center for Cellular Immunotherapiesthe Abramson Cancer Center at the Perelman School of Medicine,University of Pennsylvania+1 种基金the Parker Institute for Cancer ImmunotherapyPeking University
文摘Cancer is one of the leading causes of death worldwide. Recent advances in cellular therapy have demonstrated that this platform has the potential to give patients with certain cancers a second chance at life. Unlike chemical compounds and proteins, cells are living, self-replicating drugs that can be engineered to possess exquisite specificity. For example, T cells can be genetically modified to express chimeric antigen receptors (CARs), endowing them with the capacity to recognize and kill tumor cells and form a memory pool that is ready to strike back against persisting malignant cells. Anti-CD19 chimeric antigen receptor T cells (CART19s) have demonstrated a remarkable degree of clinical efficacy for certain malignancies. The process of developing CART19 essentially follows the conventional “one gene, one drug, one disease” paradigm derived from Paul Ehrlich’s “magic bullet” concept. With major players within the pharmaceutical industry joining forces to commercialize this new category of “living drugs,” it is useful to use CART19 as an example to examine the similarities and differences in its development, compared with that of a conventional drug. In this way, we can assimilate existing knowledge and identify the most effective approach for advancing similar strategies. This article reviews the use of biomarker-based assays to guide the optimization of CAR constructs, preclinical studies, and the evaluation of clinical efficacy;adverse effects (AEs);and CART19 cellular kinetics. Advanced technologies and computational tools that enable the discovery of optimal targets, novel CAR binding domains, and biomarkers predicting clinical response and AEs are also discussed. We believe that the success of CART19 will lead to the development of other engineered T cell therapies in the same manner that the discovery of arsphenamine initiated the era of synthetic pharmaceuticals.
基金Department of Transport/Sun GrantUS Department of Agriculture/ Department of Energy+4 种基金Minnesota Legislative-Citizen Commission on Minnesota ResourcesMetropolitan Council Environmental ServicesUniversity of Minnesota MNDrive programsUniversity of Minnesota Center for BiorefiningChina Scholarship Council (CSC) for their financial support for this work
基金support from the Royal Thai Government and the Bertucci Graduate Fellowship for this research. P. Chris Pistoriussupport from Early Stage Innovations under National Aeronautics and Space Administration (NASA)’s Space Technology Research Grants Program (NNX 17AD03G)
文摘The world’s longest and deepest tunnel,the 57.1 km long Gotthard Base Tunnel,was officially opened on June 1,2016 after 20years of effort[1,2],as shown in Fig.1[3,4].The tunnel,actually twin tubes,under the Gotthard Massif of the Swiss Alps connects Erstfeld in the north to Bodio in the south,effectively connecting northern and southern Europe with a high speed-high
文摘Functional crystals are the basic materials for the development of modern science and technology and are playing key roles in the modern information era. In this paper, we review functional crystals in China, including research history, significant achievements, and important applications by highlighting the most recent progress in research. Challenges for the development of functional materials are discussed and possible directions for development are proposed by focusing on potential strengths of these materials.
